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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Title Page

Abstract

Contents

INTRODUCTION 9

MATERIALS AND METHODS 18

Materials 18

Cell culture 18

Measurement of melanin content 18

cAMP immunoassay 18

Reporter assays 19

Western blot analysis 19

Evaluation of suppression of hair graying effects on MITFvit/vit mice depilated repeatedly(이미지참조) 21

Statistical evaluation 22

RESULTS 23

PT extract and puerarin induced melanogenesis in melanocytes 23

PT extract and puerarin increased the cellular cAMP level 23

PT extract and puerarin stimulated the transcriptional activity of pMITF-Gluc 25

PT extract and puerarin stimulated the melanogenesis related protein expression 27

PT extracts restored melanogenesis of zebrafish treated with 1-phenyl-2-thiourea 31

PT extracts and puerarin suppressed hair graying of MITFvit/vit mice(이미지참조) 34

DISCUSSION 37

REFERENCES 42

국문초록 48

List of Figures

Figure 1. Schematic and histological representations of the distribution of... 10

Figure 2. Schematic representation of early catagen hair follicle showing loss... 12

Figure 3. (A)Transcriptional and post-translational regulation of the MITF... 13

Figure 4. Characteristics of (A) Pueraria thunbergiana (family Leguminosae)... 16

Figure 5. (A) Effect of puerarin and PT extract on melanin content in melan-a cells. After incubation of melan-a cells with 100μM IBMX,... 24

Figure 6. (A) Construction of promoter reporter assays of MITF, tyrosinase, TRP-2 in melan-a cell. Mitf, tyrosinase, TRP-2 promoter activity... 26

Figure 7. (A, B) Effect of puerarin and PT extract on the key regulating... 30

Figure 8. The Effects of PT extract on the pigmentation of zebrafish. 33

Figure 9. The Effects of PT extract and puerarin on the restoration of hair... 36

Figure 10. The mechanism of PT extract and puerarin on melanogenesis 39

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