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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Abstract 13

I. 서론 15

1. 연구 배경 및 필요성 15

2. 연구 목적 17

II. 연구 방법 18

1. 연구 대상 18

1) 사업장 근로자 18

2) 산업단지 인근 거주 주민 18

3) 일반 생활환경 거주 주민(일반인) 19

2. 측정 및 분석 19

1) 톨루엔의 개인노출 19

2) 톨루엔의 생체시료 20

3. 통계 분석 21

III. 연구 결과 22

1. 대상자들의 일반적 특성 22

1) 사업장 근로자 22

2) 산업단지 인근 거주 주민 24

3) 일반 생활환경 거주 주민(일반인) 26

2. 톨루엔의 개인노출과 요 중 마뇨산 농도 28

1) 톨루엔의 개인노출 농도 28

2) 요 중 마뇨산 농도 36

3. 톨루엔의 개인노출과 요 중 마뇨산 농도의 상관성 43

1) 사업장 근로자 43

2) 산업단지 인근 거주 주민 50

3) 일반 생활환경 인근 거주 주민(일반인) 57

4) 전체 연구 대상자(사업장, 산업단지 인근, 일반 생활환경) 64

4. 톨루엔의 개인노출 농도를 이용한 요 중 마뇨산 농도 추정 71

1) 지수성장모델을 이용한 회귀 분석 71

2) 지수성장모델을 이용한 노출평가 방법 제시 72

3) 톨루엔 기준치를 이용한 마뇨산 기준치 예측 73

IV. 고찰 75

V. 결론 81

참고 문헌 83

표목차

Table 1. General characteristics of occupational workers 23

Table 2. General characteristics of area affected by industrial complex 25

Table 3. General characteristics of general public in general environments 27

Table 4. Personal exposure concentrations (ppb) of airborne toluene 29

Table 5. Personal exposure concentrations (ppb) of airborne toluene according to gender 31

Table 6. Personal exposure concentrations (ppb) of airborne toluene according to age 32

Table 7. Personal exposure concentrations (ppb) of airborne toluene according to smoking 34

Table 8. Personal exposure concentrations (ppb) of airborne toluene according to alcohol 35

Table 9. Urinary hippuric acid concentrations (g/g-creatinine) of participants 37

Table 10. Urinary hippuric acid concentrations (g/g-creatinine) of participants according to gender 38

Table 11. Urinary hippuric acid concentrations (g/g-creatinine) of participants according to age 39

Table 12. Urinary hippuric acid concentrations (g/g-creatinine) of participants according to smoking 41

Table 13. Urinary hippuric acid concentrations (g/g-creatinine) of participants according to alcohol 42

Table 14. Correlation between personal exposures to toluene and urinary hippuric... 44

Table 15. Correlation between personal exposures to toluene and urinary hippuric... 51

Table 16. Correlation between personal exposures to toluene and urinary hippuric... 58

Table 17. Correlation between personal exposures to toluene and urinary hippuric... 65

Table 18. Recommended reference values of urinary hippuric acid using toluene reference values in this study 74

그림목차

Figure 1. Personal exposure concentrations to airborne toluene... 28

Figure 2. Correlation between personal exposures to toluene and urinary... 45

Figure 3. Correlation between personal exposures to toluene and urinary... 46

Figure 4. Correlation between personal exposures to toluene and urinary... 47

Figure 5. Correlation between personal exposures to toluene and urinary... 48

Figure 6. Correlation between personal exposures to toluene and urinary... 49

Figure 7. Correlation between personal exposures to toluene and urinary... 52

Figure 8. Correlation between personal exposures to toluene and urinary... 53

Figure 9. Correlation between personal exposures to toluene and urinary... 54

Figure 10. Correlation between personal exposures to toluene and urinary... 55

Figure 11. Correlation between personal exposures to toluene and urinary... 56

Figure 12. Correlation between personal exposures to toluene and urinary... 59

Figure 13. Correlation between personal exposures to toluene and... 60

Figure 14. Correlation between personal exposures to toluene and urinary... 61

Figure 15. Correlation between personal exposures to toluene and urinary... 62

Figure 16. Correlation between personal exposures to toluene and urinary... 63

Figure 17. Correlation between personal exposures to toluene and urinary... 66

Figure 18. Correlation between personal exposures to toluene and... 67

Figure 19. Correlation between personal exposures to toluene and urinary... 68

Figure 20. Correlation between personal exposures to toluene and urinary... 69

Figure 21. Correlation between personal exposures to toluene and... 70

Figure 22. Correlation between personal exposures to toluene and... 71

Figure 23. Interception points of personal exposures for toluene... 72

초록보기

Exposure to toluene in the air may occur in the occupational environment where toluene is frequently used as a solvent. And the high concentration of toluene may be measured in residence indoor air from the use of common household products and in residents near industrial complex. We may be exposed to toluene from many sources, including drinking water, food, air, and consumer products, and may also be exposed to toluene through breathing the chemical in the workplace or during deliberate glue sniffing or solvent abuse. Therefore the researches for exposure to toluene are needed, considering toluene has been known as a reproductive toxicant and central nervous system depression. Exposure assessment can be carried out directly such as personal exposure and biological monitoring or indirectly methods.

In this study, the toluene levels of personal exposures and urinary hippuric acids of biological monitoring were measured in occupational environments, area affected by industrial complex and general environments. And then relationship among them was regressed.

Average personal exposure levels of toluene in occupational environment, area affected by industrial complex and general environments were 33.69 ppm, 0.0305 ppm and 0.0096 ppm, respectively. And average hippuric acid, metabolite of toluene, concentrations were 1.02 g/g creatinine, 0.40 g/g creatinine and 0.25 g/g creatinine in occupational environments, near the industrial complex and general environments, respectively.

The regression equation between personal exposure and biological monitoring of toluene showed a decreasing trend in area affected by industrial complex and general environments, whereas showed the increasing trend in the occupational environments. Combining the total measured data, the coefficient of determination (R²) between personal exposure and biological monitoring on toluene was 0.41. This study suggested that relationship between personal exposure and biological monitoring could be obtained by combining the levels measured by general environments (low), area affected by industrial complex (medium) and occupational environments (high). With this relationship, reference values of urinary hippuric acid were estimated by standards or reference values of personal exposure to toluene.

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