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The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated

extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the

EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies.

From the physico-chemical data, including NMR, MS and IR, the chemical structures of

the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol

(3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl

aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first

time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma

(HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values

ranging from 19.1 to 71.3 µg/mL.

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기사명 저자명 페이지 원문 목차
Quinolone alkaloids from Evodiae Fructus and their inhibitory effects on monoamine oxidase Xiang Hua Han ;Seong Su Hong ;Dongho Lee ;Jung Joon Lee ;Moon Soon Lee ;Dong-cheul Moon ;Kun Han ;Ki pp.397-401

Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines Dae-young Lee ;Myoung-chong Song ;Ki-hyun Yoo ;Myun-ho Bang ;In-sik Chung ;Sung-hoon Kim ;Dae-keun K pp.402-407

A new cytotoxic prenylated chalcone from Sophora flavescens Jae Hyeok Lee ;Nam-in Baek ;Sung-hoon Kim ;Hee Wook Park ;Jae Heon Yang ;Jeong Joo Lee ;Seong Jin Ki pp.408-411

Triterpenoids and diarylheptanoids from Alnus hirsuta inhibit HIF-1 in AGS cells Wenyi Jin ;Xing Fu Cai ;Minkyun Na ;Jung Joon Lee ;Kihwan Bae pp.412-418

Analgesic and antiinflammatory activities of some new Mannich bases of 5-nitro-2-benzoxazolinones Meriç Köksal ;Nesrin Gökhan ;Esra Küpeli ;Erdem Yesilada ;Hakki Erdogan pp.419-424

A new lignan glycoside from the stem bark of Styrax japonica S. et Z Mi-ran Kim ;Hyun Teak Moon ;Dong Gun Lee ;Eun-rhan Woo pp.425-430

A new iridoid and other chemical constituents from Pedicularis kansuensis forma albiflora Li Jun-gang Yin ;Cheng-shan Yuan ;Zhong-jian Jia pp.431-435

Effects of constituents of Amomum xanthioides on gastritis in rats and on growth of gastric cancer cells Yong Soo Lee ;Min Hee Kang ;So Yean Cho ;Choon Sik Jeong pp.436-443

Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter, LAT1 Shadi Baniasadi ;Arthit Chairoungdua ;Yuji Iribe ;Yoshikatsu Kanai ;Hitoshi Endou ;Ken-ichi Aisaki ; pp.444-452

Maprotiline block of the human ether-a-go-go-related gene (HERG) K^+^ channel Su-hyun Jo ;Hee-kyung Hong ;Sung Jun Jung ;Seon Ha Chong ;Ji-hyun Yun ;Young-sang Koh ;Han Choe pp.453-460

The inhibitory effect of rosiglitazone on agonist-induced or spontaneous regulation of contractility Hyun Dong Je ;Sun Young Park ;Amy L. Barber ;Uy Dong Sohn pp.461-468

Enzyme kinetic study of a new cardioprotective agent, KR-32570 using human liver microsomes and recombinant CYP isoforms Hyojin Kim ;kyung-ah Seo ;Hyunmi Kim ;Hye Suk Lee ;Choong-hwan Lee ;Jae-gook Shin ;Kwang-hyeon Liu pp.469-474

Antithrombotic effects by oral administration of novel proteinase fraction from earthworm Eisenia andrei on venous thrombosis model in rats Chul Kyu Lee ;Jang Sik Shin ;Byung Su Kim ;Il Hwan Cho ;Young Shik Kim ;Eun Bang Lee pp.475-480

The role of intestinal microflora on daidzein excretion in urine in humans treated with Chungpesagantang Young-suk Kim ;Hwa-jun Lee ;Ki-ho Cho ;Hyung-sup Bae ;Eun-kyung Park ;Dong-hyun Kim pp.481-485

Rolipram, a phosphodiesterase 4 inhibitor, suppresses PGE₂-induced osteoclast formation by lowering osteoclast progenitor cell viability Hyojung Park ;Mijung Yim pp.486-492

Anti-hypertensive effect of the Dongchunghacho, Isaria sinclairii, in the spontaneously hypertensive rats Mi Young Ahn ;Yi Sook Jung ;Sang Deok Jee ;Chan Shik Kim ;Su Hwan Lee ;Chang Hyun Moon ;Sung Ig Cho pp.493-501

Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development Chang-hwan Choi ;Ji-seon Jeong ;Bo-im Yoo ;You-xun Jin ;Dong-cheul Moon ;Hwan-soo Yoo ;Seikwan Oh ;S pp.502-506

Peptide transporter substrate identification during permeability screening in drug discovery :comparison of transfected MDCK-hPepT1 cells to Caco-2 cells Praveen. V. Balimane ;Saeho Chong ;Karishma Patel ;Yong Quan ;Julita Timoszyk ;Yong-hae Han ;Bonnie pp.507-518

Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles Qing-yu Xiang ;Min-ting Wang ;Fu Chen ;Tao Gong ;Yan-lin Jian ;Zhi-rong Zhang ;Yuan Huang pp.519-525

Sustained release of amoxicillin from chitosan tablets Teerawat Sahasathian ;Teerachai Kerdcholpetch ;Akapol Chanweroch ;Narong Praphairaksit ;Narumon Suwo pp.526-531

참고문헌 (15건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Phytochemistry, biochemical systematics and ecology 네이버 미소장
2 (19-1211983) Carbon-13 NMR spectral analysis of dihydrobenzofuran lignans. OMR, 미소장
3 (2006) Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia, 미소장
4 (1982) a new neo-lignan from Balanophora japonica Makino. Chem. Pham. Bull., 미소장
5 (2002) Immuno-regulatory property of fruit-extracts of Cornus kousa Burg, 미소장
6 (2003) In Coloured Flora of Korea, Hyang Mun Sa, Seoul, Korea 미소장
7 (2003) Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of enterococcus faecalis Strain PDG-1 responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol, 미소장
8 (2003) Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis, 미소장
9 Lignans of Larix leptolepis 네이버 미소장
10 (1983) Rapid colorimetric asay for cellular growth and survival application to proliferation and cytotoxicity assay. J. Immunol. Methods, 미소장
11 (1995) Pharmacolo- gically active components of Todopon Puok (Fagraea racemosa), a medicinal plant from Borneo, 미소장
12 (1971) On the constituents of leaves of Cornus kousa Burg. Kor. J. Pharmacogn., 미소장
13 (2006) Anthocyanins in Cornus alternifolia, Coruns controversa, Cornus kousa and Cornus florida fruits with health benefits, 미소장
14 (1994) The pictorial book of Chinese medicinal herbs. Yeo- Gang Press, 미소장
15 Initial reactions in the fungal degradation of guaiacylglycerol-b-coniferyl ether, 미소장

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