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한국학술지인용색인(NRF)
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Purpose: This study was conducted to investigate the efficacy of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) in women with climacteric symptoms, and to assess their effects on vaginal atrophy, hormone levels, and lipid profiles. Materials and Methods: In this double-blind randomized, placebo-controlled, multicenter study, 89 peri- or postmenopausal women experiencing climacteric symptoms were treated with St. John's wort and black cohosh extract (Gynoplusⓡ), Jin-Yang Pharm., Seoul, Korea) or a matched placebo for 12 weeks. Climacteric complaints were evaluated by the Kupperman Index (KI) initially and at 4 and 12 weeks following treatment. Vaginal maturation indices, serum estradiol, FSH, LH, total cholesterol, HDL- cholesterol, LDL-cholesterol, and triglyceride levels were measured before and after treatment. From the initial 89 participants, 77 completed the trial (42 in the Gynoplus group, 35 in the placebo group). Results: Baseline characteristics were not significantly different between the two groups. Mean KI scores and hot flushes after 4 and 12 weeks were significantly lower in the Gynoplus group. Differences in superficial cell proportion were not statistically significant. HDL levels decreased in the control group from 60.20±16.37 to 56.63±12.67, and increased in the Gynoplus group from 58.32±11.64 to 59.74±10.54; this was statistically significant (p=0.04). Conclusion: Black cohosh and St. John's wort combination was found to be effective in alleviating climacteric symptoms and might provide benefits to lipid metabolism.
권호기사
참고문헌 (22건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | (expgerontol1994) quality of life and search for treatment options, | 미소장 |
| 2 | (2001) Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple outcomes of raloxifene evaluation, | 미소장 |
| 3 | (2001) Cardiovascular trials of estrogen replacement therapy, | 미소장 |
| 4 | (1998) Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/ progestin Replacement Study (HERS) Research Group, | 미소장 |
| 5 | (2001) Genotoxicity of the steroidal oestrogens oestrone and oestradiol: possible mechanism of uterine and mammary cancer development, | 미소장 |
| 6 | (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health initiative randomized controlled trial., | 미소장 |
| 7 | (1999) Hormone-modulating herbs: implications for women's health, | 미소장 |
| 8 | (1999) Menopausal symptoms and alternative medicine, | 미소장 |
| 9 | (2003) Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor, | 미소장 |
| 10 | (1998) A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause, | 미소장 |
| 11 | (therapeutikon1987) Phytopharmaceutical influences of atrophic vaginal epithelium double-blind study on Cimifuga vs, | 미소장 |
| 12 | (2001) Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer, | 미소장 |
| 13 | (2003) The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers, | 미소장 |
| 14 | A Randomized Trial of a Multicomponent Home Intervention to Reduce Functional Difficulties in Older Adults  |
미소장 |
| 15 | (jclinendocrinol1953) Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorrheal indices, | 미소장 |
| 16 | [Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa]. |
미소장 |
| 17 | (2006) Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG trial N01CC, | 미소장 |
| 18 | (2005) Pathophysiology and treatment of menopausal hot flashes, | 미소장 |
| 19 | (2003) In vitro effects of the Cimicifuga racemosa extract BNO 1055, | 미소장 |
| 20 | (2004) Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women, | 미소장 |
| 21 | (2006) Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study, | 미소장 |
| 22 | (2006) First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055, | 미소장 |
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