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The leukocyte recruitment and transmigration across the endothelial barrier into the vessel wall are crucial steps in atherosclerosis. Leukocyte

trafficking on the endothelium is elicited by induction of endothelial adhesion molecules, and its transmigration is mediated by degradation of basement

membrane proteins through enzymatic activity of matrix metalloproteinases (MMP). The current study investigated whether resveratrol, a polyphenol

present in grapes and red wine, was capable of inhibiting leukocyte adhesion to tumor necrosis factor (TNF)-α-activated endothelium. It was found

that resveratrol inhibited the TNF-α-activated endothelial expression of vascular cell adhesion molecule-1 in a dose-dependent manner. In addition,

resveratrol hampered THP-1 monocyte adhesion to activated endothelial cells. This study further examined whether resveratrol interfered with transendothelial

migration of leukocytes. The MMP-2 gelatinolytic activity of endothelial cells was enhanced by TNF-α, which was attenuated by an addition of

≥25 μM resveratrol. In addition, 25 μM resveratrol mitigated the MMP-9 activity of THP-1 cells, followed by a marked inhibition of transendothelial

migration. These results demonstrated that resveratrol suppressed monocyte adhesion and migration induced by TNF-α through modulating expression

of adhesion molecules and gelatinolytic activity of MMP. These findings suggest that dietary resveratrol may be therapeutic agent for inhibiting

leukocyte recruitment into the subendothelium during inflammatory atherosclerosis.

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기사명 저자명 페이지 원문 목차
Alpha-tocopherol transfer protein(α-TTP) :insights from alpha-tocopherol transfer protein knockout mice Yunsook Lim ;Maret G. Traber pp.247-253

Childbearing women of twenty and under are at greater risk than those of twenty-five and over for compromised folate status Hee-ah Kim ;Jeong-hwa Choi ;Hyeon-sook Lim pp.254-259

Influence of preserved brewing yeast strains on fermentation behavior and flocculation capacity Chul Cheong ;Karl Wackerbauer ;Martin Beckmann ;Soon Ah Kang pp.260-265

Soybean isoflavone extract improves glucose tolerance and raises the survival rate in streptozotocin-induced diabetic rats Jee-youn Shim ;Kwang-ok Kim ;Bo-hyun Seo ;Hye-sung Lee pp.266-272

The inhibitory effect of natural bioactives on the growth of pathogenic bacteria Ji-sun Kim ;Yangha Kim pp.273-278

Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts Ji-young Bae ;Soon Sung Lim ;Jung-suk Choi ;Young-hee Kang pp.279-284

Resveratrol blunts tumor necrosis factor-α-induced monocyte adhesion and transmigration Dong Shoo Kim ;Hyang-mi Kwon ;Jung-suk Choi ;Sang-wook Kang ;Geun-eog Ji ;Young-hee Kang pp.285-290

Effect of dietary soluble fiber on neurohormonal profiles in serum and brain of rats Dongsoon Shin pp.291-297

Effect of coenzyme Q10 and green tea on plasma and liver lipids, platelet aggregation, TBARS production and erythrocyte Na leak in simvastatin treated hypercholesterolmic rats Yang Hee Kim ;Young In Moon ;Young Hee Kang ;Jung Sook Kang pp.298-304

Intake of dietary phytoestrogen and indices of antioxidant and bone metabolism of pre- and post-menopausal Korean women Jeong-hee Jang ;Ji-young Yoon ;Sung-hee Cho pp.305-312

Comparison of major dish item and food group consumption between normal and obese Korean children :application to development of a brief food frequency questionnaire for obesity-related eating behaviors Seungmin Lee ;Hong-seok Ahn pp.313-320

Do mother's interests in weight control influence preschoolers' obesity and weight related concerns? Aewha Ha pp.321-327

Relationship of nutrient intakes and bone mineral density of elderly women in Daegu, Korea Mi-ja Choi ;Eun-jin Park ;Hyun-ju Jo pp.328-334

Relation of serum total antioxidant status with metabolic risk factors in Korean adults Ho-kyung Kwak ;Sun Yoon pp.335-340

Study on utilization status of internet and needs assessment for developing nutrition education programs among elementary school children Yun Ahn ;Kyung-won Kim pp.341-348

Influence of stress on snack consumption in middle school girls Eun-young Jeong ;Ki-nam Kim pp.349-355

The decreased molar ratio of phytate:zinc improved zinc nutriture in south Koreans for the past 30 years, 1969-1998 Mi-sook Do ;Ria-Ann R. Lomeda ;Young-eun Cho ;In-sook Kwun pp.356-362

Adiponectin gene SNP 276G→T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients So Young Yu ;Han Kyoung Ryu ;Hee Jung Park ;Young Ju Choi ;Kap Bum Huh ;Wha Young Kim pp.363-370

Hypolipidemic effect of Salicornia herbacea in animal model of type 2 diabetes mellitus Ji-yeon Hwang ;Soo-kyung Lee ;Ja-rim Jo ;Mi-eun Kim ;Hyun-ah So ;Chang-woo Cho ;Young-wan Seo ;Jung- pp.371-375

참고문헌 (32건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 J Nutr. 2005 Apr;135(4):707-13 미소장
2 Biomed Pharmacother. 2005 Aug;59(7):359-64 미소장
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4 Int J Toxicol. 2006 Jul-Aug;25(4):295-301 미소장
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6 Pharmacol Rev. 2000 Dec;52(4):673-751 미소장
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8 Circulation. 2001 Oct 9;104(15):1754-6 미소장
9 Biochem Biophys Res Commun. 2007 Dec 28;364(4):972-7 미소장
10 Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):17-24 미소장
11 Nutrition. 2002 Feb;18(2):173-7 미소장
12 Atherosclerosis. 2007 Nov;195(1):e125-33 미소장
13 J Biol Chem. 1993 Aug 15;268(23):17354-61 미소장
14 J Clin Invest. 1994 Dec;94(6):2493-503 미소장
15 Front Biosci. 2007 Sep 01;12:4839-54 미소장
16 Cardiovasc Drug Rev. 2004 Fall;22(3):169-88 미소장
17 Life Sci. 2005 Dec 12;78(4):389-97 미소장
18 Ann N Y Acad Sci. 2001 Dec;947:93-109; discussion 109-11 미소장
19 Nat Rev Drug Discov. 2006 Jun;5(6):493-506 미소장
20 Alcohol Clin Exp Res. 2007 Aug;31(8):1308-14 미소장
21 Eur J Pharmacol. 2004 Oct 1;500(1-3):299-313 미소장
22 Int J Biochem Cell Biol. 2000 Jul;32(7):687-93 미소장
23 Am J Clin Nutr. 2001 Oct;74(4):418-25 미소장
24 Free Radic Biol Med. 2005 Oct 15;39(8):1099-108 미소장
25 Bioorg Med Chem. 2006 Mar 1;14(5):1437-43 미소장
26 Ann N Y Acad Sci. 2002 May;957:146-61 미소장
27 Transplantation. 1990 Oct;50(4):537-44 미소장
28 Int J Tissue React. 1995;17(1):1-3 미소장
29 Inflamm Res. 2000 Feb;49(2):55-62 미소장
30 Arterioscler Thromb Vasc Biol. 1998 May;18(5):842-51 미소장
31 Nature. 1993 Apr 29;362(6423):801-9 미소장
32 J Med Food. 2004 Fall;7(3):290-8 미소장

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