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To investigate the possible enhancement of genotoxicity in stress environment, we examined the effect ofgenotoxic material in oxidative stress-induced condition using human cell line. Human lymphoblast cell line,TK6 was treated with hydrogen peroxide (H2O2) for induction of oxidative stress, and treated with N′-methyl-N′-nitroguanidine (MNNG), as a genetoxic material. We carried out MTS assay to set treatment doses. TK6was treated with H2O2 as 6.75(low dose) or 13.5M(high dose) for 2h, and treated with MNNG as 0.117(lowdose), 0.234(middle dose), 0.468M(high dose) for 2h. As results, a treatment of MNNG induced DNA dam-age as dose dependently. And TK6 treated with H2O2 at low as well as high dose followed by MNNG treat-ment showed higher DNA damage compared to MNNG alone treated groups. Malondialdehyde, as a marker oflipid peroxidation was increased in H2O2 and MNNG treated groups. Real-time RT-PCR analyses for expres-sion were decreased in H2O2 and MNNG treated groups. Taken together, we conclude that genotoxicity inducedby MNNG is enhanced in a condition of oxidative stress induced by H2O2 and it suggests that it should be asso-ciated with induction of lipid peroxidation and decrease of antioxidant enzymes.

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참고문헌 (19건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Alija AJ, (2005) Cyto-and genotoxic potential of beta-carotene and cleavage products under oxidative stress, 미소장
2 Alija AJ, (2006) Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes, 미소장
3 Alija AJ, (2004) Cytotoxic and genotoxic effects of beta-carotene breakdown products on primary rat hepatocytes, Car-, 미소장
4 Elchuri S, (2005) CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life, 미소장
5 Fukushima S, (1999) Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment, 미소장
6 Kang JS, (2006) Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats, 미소장
7 Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. 네이버 미소장
8 Wakabayashi K, Kurosaka R and Nagao M. Dose-response study of MeIQx carcino- genicity in F344 male rats, 미소장
9 Mates JM, (1999) Antioxi- dant enzymes and human diseases, 미소장
10 Nagao M, (1999) A new approach to risk estimation of food-borne carcinogens--heterocyclic amines-based on molecular information, 미소장
11 Nagao M, (1997) Genetic changes induced by heterocyclic amines, 미소장
12 Hasegawa H, and Sugimura T. Carcinogenicity in mice of a mutage- nic compound, 미소장
13 Ostling O, Microelectrophoretic study of radiation-induced DNA damages in individual mam- malian cells, 미소장
14 Ran Q, (2007) Transge- nic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis, 미소장
15 Kang, 스트레스에 의한 MNNG의 유전독성 증가 365, 미소장
16 Reliene R, (2006) Glutathione depletion by buthi- onine sulfoximine induces DNA deletions in mice, 미소장
17 Sanz N, (1995) Relationship between antioxidant sys- tems, intracellular thiols and DNA ploidy in liver of rats during experimental cirrhogenesis, 미소장
18 Studies on Environmental Chemical Carcinogenesis in Japan 네이버 미소장
19 Sugimura T, Nutrition and dietary carcinogens, 미소장

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