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Flavonoids have been shown to affect calcium signaling in neurons. However, there are no reports

on the effect of apigenin on glutamate-induced calcium signaling in neurons. We investigated whether

apigenin affects glutamate-induced increase of free intracellular Ca²+ concentration ([Ca²+]i) in cultured

rat hippocampal neurons, using fura-2-based digital calcium imaging and microfluorimetry. The

hippocampal neurons were used between 10 and 13 days in culture from embryonic day 18 rats.

Pretreatment of the cells with apigenin (1μM to 100μM) for 5 min inhibited glutamate (100μM, 1

min) induced [Ca²+]i increase, concentration-dependently. Pretreatment with apigenin (30μM) for 5 min

significantly decreased the [Ca²+]i responses induced by two ionotropic glutamate receptor agonists,

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA, 10μM, 1 min) and N-methyl-D-aspartate

(NMDA, 100μM, 1 min), and significantly inhibited the AMPA-induced peak currents. Treatment with

apigenin also significantly inhibited the [Ca²+]i response induced by 50 mM KCl solution, decreased

the [Ca²+]i responses induced by the metabotropic glutamate receptor agonist, (S)-3,5-dihydroxyphenylglycine

(DHPG, 100μM, 90 s), and inhibited the caffeine (10 mM, 2 min)-induced [Ca²+]i

responses. Furthermore, treatment with apigenin (30μM) significantly inhibited the amplitude and

frequency of 0.1 mM [Mg²+]o-induced [Ca²+]i spikes. These data together suggest that apigenin inhibits

glutamate-induced calcium signaling in cultured rat hippocampal neurons.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Melatonin induces Akt phosphorylation through melatonin receptor- and PI3K-dependent pathways in primary astrocytes Pil-jae Kong ;Jong-seon Byun ;So-young Lim ;Jae-jun Lee ;Sung-jun Hong ;Kwang-jun Kwon ;Sung-soo Kim pp.37-41

Effects of apigenin on glutamate-induced [Ca^2+^]_i_ increases in cultured rat hippocampal neurons Ji-hwa Han ;Ki Jung Kim ;Hyun-jong Jang ;Ju Ho Jang ;Myung-jun Kim ;Ki Wug Sung ;Duck-joo Rhie ;Yang pp.43-49

Expression of Ca^2+^-activated K^+^ channels and their role in proliferation of rat cardiac fibroblasts Seyong Choi ;Wooseok Lee ;Jihyun Yun ;Jeongseok Seo ;Inja Lim pp.51-58

Relaxant effect of spermidine on acethylcholine and high K^+^- induced gastric contractions of guinea-pig Young Chul Kim ;Jae Hoon Sim ;Woong-Choi ;Chan Hyung Kim ;Ra-young You ;Wen-xie Xu ;Sang Jin Lee pp.59-64

Glycyrrhizin attenuates MPTP neurotoxicity in mouse and MPP^+^-induced cell death in PC12 cells Yun Jeong Kim ;Chung Soo Lee pp.65-71

Testosterone relaxes rabbit seminal vesicle by calcium channel inhibition Jong Kok Kim ;Woo Ha Han ;Moo Yeol Lee ;Soon Chul Myung ;Sae Chul Kim ;Min Ky Kim pp.73-77

Protective effect of decursinol on mouse models of sepsis :enhancement of interleukin-10 Jun-sub Jung ;Ji-jing Yan ;Dong-keun Song pp.79-81

Assessment of relationship between fyn-related kinase gene polymorphisms and overweight/obesity in Korean population Mi Young Jung ;Bum Shik Kim ;Youn Jung Kim ;In Song Koh ;Joo-ho Chung pp.83-87

참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Cell cycle-dependent coupling of the vasopressin V1a receptor to different G proteins. 네이버 미소장
2 Ca2+ entry into PC12 cells initiated by ryanodine receptors or inositol 1,4,5-trisphosphate receptors. 네이버 미소장
3 Pharmacology and functions of metabotropic glutamate receptors. 네이버 미소장
4 Complex interactions between mGluRs, intracellular Ca 2+ stores and ion channels in neurons 네이버 미소장
5 Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta. 네이버 미소장
6 Calcium-induced calcium release in cerebellar purkinje cells 네이버 미소장
7 Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons 네이버 미소장
8 Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. 네이버 미소장
9 Novel neuronal phenotypes from neural progenitor cells. 네이버 미소장
10 Cellular localization of a metabotropic glutamate receptor in rat brain 네이버 미소장
11 Heterogeneity of Ca2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment. 네이버 미소장
12 Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells 네이버 미소장
13 Magnesium removal induces paroxysmal neuronal firing and NMDA receptor-mediated neuronal degeneration in cortical cultures 네이버 미소장
14 Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons. 네이버 미소장
15 Sattler R, Tymianski M. Molecular mechanisms of calciumdependent excitotoxicity. J Mol Med 78: 3−13, 2000 미소장
16 Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. 네이버 미소장
17 Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain 네이버 미소장
18 Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neurons 네이버 미소장
19 Thayer SA, Sturek M, Miller RJ. Measurement of neuronal Ca2+ transients using simultaneous microfluorimetry and electrophysiology. Pflugers Archiv - Eur J Physiol 412: 216−223, 1988 미소장
20 The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. 네이버 미소장
21 Dendritic localization of Ca2+‐permeable AMPA/kainate channels in hippocampal pyramidal neurons 네이버 미소장

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