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High levels of homocysteine promote oxidative stress, and aberrant homocysteine metabolism is linked to neurodevelopmental disorders including schizophrenia. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. The present study was conducted to examine the association between the MTHFR gene and schizophrenia in Korean population. Subjects of 279 patients with schizophrenia and 296 healthy controls were recruited. We genotyped two single nucleotide polymorphisms (SNPs, rs2274976 and rs1801133) using the Illumina Sentrix Array Matrix chip and direct sequencing. The rs2274976 (Arg594Gln) is located on exon 12 of the MTHFR gene region, and the rs1801133 (Ala222Val) located on exon 5. For the analysis of genetic data, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used. Multiple logistic regression analysis (codominant, dominant, and recessive models) was also used. Patients with schizophrenia were evaluated according to clinical manifestations using the Operational Criteria Checklist (OPCRIT). Two SNPs (rs2274976 and rs1801133) were not associated with schizophrenia. However, one SNP showed a significant association with one phenotype of psychotic symptoms. Running commanding voices, which could be clinically considered serious feature of auditory hallucinations, was different in the recessive model (p=0.018; p=0.036 after Bonferroni correction). Recently, rs59514310 replaces rs1801133 as new number (SNP database, BUILD 129). In present study, a significant association was observed between rs1801133 and running commanding voices. The result suggests that the MTHFR gene may be a susceptibility gene for schizophrenia with auditory hallucination. (Korean J Str Res 2008;16:85∼91)

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기사명 저자명 페이지 원문 목차
NEO아동성격검사에 따른 초등학생의 성격특성과 스트레스 대처방식의 관계 김옥희 ;안현의 pp.69-77

시험불안에 있어 학업스트레스와 마음챙김의 관련성 이은영 ; 박양리 ; 현명호 pp.79-84

Association between methylenetetrahydrofolate reductase(MTHFR) gene polymorphisms and Korean paitents with schizophrenia Ah Rang Cho ;Yong Ho Kim ;Bum Shik Kim pp.85-91

한국인 퇴행성 관절염 환자에서 Glutathione-S-transferase 유전자의 다형성 연구 최대정 ;김용호 ;김범식 ;임성빈 pp.93-98

강제수영실험을 통한 연자육의 항우울 효과 이규섭 ;조정원 ;강문규 ;배현수 ;김경수 ;심인섭 pp.99-106

행복과 정신건강의 긍정심리학적 접근 박주언 ;강은호 ;박영민 ;최삼욱 ;채정호 pp.107-114

감사의 효능과 치료적 적용 박영민 ;최삼욱 ;강은호 ;박주언 ;채정호 pp.115-122

행복이 건강에 미치는 영향 김정호 pp.123-141

사상의학에서 바라본 몸과 마음 :심리학적 유형론과 연관지어 김달래 pp.143-149

스트레스와 면역 고경봉 pp.151-159

심박 변이도와 스트레스, 정신장애의 연관성 김 원 pp.161-165

점진적 근육이완의 적용과 효과에 관한 최신 지견 서경현 pp.167-173

몸과 마음의 이완을 위한 스트레칭 김명화 pp.175-180

참고문헌 (36건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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16 Lewis SJ, Zammit S, Gunnell D, Smith GD (2005) A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. Am J Med Genet B 135B:2-4. 미소장
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20 Muntjewerff JW, Hoogendoorn MLC, Kahn RS, et al (2005) Hyper-homocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study. Am J Med Genet B 135B:69-72. 미소장
21 Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M (2006) Homo-cysteine, methylenetetrahydrofolate reductase and risk of schizo-phrenia: a meta-analysis. Mol Psychiatry 11:143-149. 미소장
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