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New basal insulin formulation was designed and their structural characteristics were investigated in vitro and biological activities in type 1 diabetic rats. Zinc-crystallized insulin was physically loaded into hydrophobically modified glycol chitosan (HGC) nanoparticles by a dialysis method. The series of insulin-HGC formulations were prepared with different feed weight ratio of insulin to HGC from 0.5:1 to 4:1. The loading contents of insulin and size distribution of insulin-HGCs were characterized, and blood glucose responses were investigated in streptozotocin-induced diabetic rats after single subcutaneous injection of regular insulin and insulin-HGCs. The highest loading efficiency and content were obtained in insulin-HGC when a 1:1 feed weight ratio of insulin to HGC was employed. The hydrodynamic diameter of insulin-HGC nanoparticles were in the range of 200 to 500 nm with narrow size distribution. Insulin-HGC effectively sustained insulin release up to 40% within 12 hours followed by a slower controlled release. Insulin-HGC showed an extended blood glucose lowering effect up to 24 h and provided normal blood glucose levels after oral glucose (1.5 g/kg) load at 24 hours post-injection while regular insulin showed severe hypoglycemia. The prolonged time action profiles and low variability of insulin-HGC formulation resulted in improved blood glucose control in diabetic rats and fulfilled a pattern desirable of a basal insulin.

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Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells Phan Van Kiem ;Tran Hong Quang ;Tran Thu Huong ;Le Thi Hong Nhung ;Nguyen Xuan Cuong ;Chau Van Minh pp.823-829

A new lignan glycoside from the fruits of cornus kousa burg Dae-Young Lee ;Ki-Hyun Yoo ;In-Sik Chung ;Ji-Young Kim ;Dae-Kyun Chung ;Dae-Keun Kim ;Sung-Hoon Kim pp.830-833

Synthesis and hypnotic activities of N-Cbz-α-aminoglutarimi-dooxy carboxylate derivatives Aesun Byun ;Jin Yup Park ;Kyung Hee Moon ;Min Soo Park pp.834-837

Synthesis and anticonvulsant evaluation of 6-amino-1,4-oxazepane-3,5-dione derivatives Gitalee Sharma ;Jin Yup Park ;Min Soo Park pp.838-842

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Inhibitors of bone resorption from Halenia corniculata Jin Zhang ;Mi-Jeong Ahn ;Qi Shi Sun ;Ki-Yoon Kim ;Yun Ha Hwang ;Jei Man Ryu ;Jinwoong Kim pp.850-855

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참고문헌 (16건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 The lung as a route for systemic delivery of therapeutic proteins and peptides 네이버 미소장
2 Insulin Pharmacokinetics 네이버 미소장
3 Insulin analogs with improved pharmacokinetic profiles 네이버 미소장
4 Concept, strategies, and feasibility of noninvasive insulin delivery. 네이버 미소장
5 Protein drug stability: a formulation challenge 네이버 미소장
6 New concept for long-acting insulin: spontaneous conversion of an inactive modified insulin to the active hormone in circulation: 9-fluorenylmethoxycarbonyl derivative of insulin. 네이버 미소장
7 Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albumin. 네이버 미소장
8 Biodegradable nanoparticles for drug delivery and targeting 네이버 미소장
9 Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel 네이버 미소장
10 Physicochemical Characteristics of Self-Assembled Nanoparticles Based on Glycol Chitosan Bearing 5β-Cholanic Acid 네이버 미소장
11 Insulin glargine: a review of its therapeutic use as a long-acting agent for the management of type 1 and 2 diabetes mellitus. 네이버 미소장
12 New horizons — alternative routes for insulin therapy 네이버 미소장
13 Synthesis and Characterization of Sugar-Bearing Chitosan Derivatives:  Aqueous Solubility and Biodegradability 네이버 미소장
14 Sinha, V. R., (2004) Chitosan microspheres as a potential carrier for drugs, Int. J. Pharm 미소장
15 Lessons from Studies of Insulin Pharmacokinetics 네이버 미소장
16 Recent progress in protein and peptide delivery by noninvasive routes. 네이버 미소장

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