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During embryonic and cancer development, the Hedgehog family of proteins, including Sonic Hedgehog, play an important role by relieving the inhibition of Smo by Ptc, thus activating the Smo signaling cascade. Recently, a purine compound, purmorphamine, has been reported to target the Hedgehog signaling pathway by interacting with Smo. Interestingly, both Sonic Hedgehog and purmorphamine were found to promote the osteogenic differentiation of mouse chondroprogenitor cells. However, there is insufficient information as to how the activation of this seemingly unrelated signaling pathway, either by Sonic Hedgehog or purmorphamine, contributes to osteogenesis.

Using alkaline phosphatase assays, we screened 125 purmorphamine derivatives from the Korea Chemical Bank for effects on the differentiation of preosteoblast C2C12 cells. Here, we report that two purine derivatives modulate ALP activity as well as the expression of genes whose expression is known or suggested to be involved in osteogenesis.

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기사명 저자명 페이지 원문 목차
Proteotoxic stress and cell lifespan control Simone Cenci ;Niccolò Pengo ;Roberto Sitia pp.323-328

Src redox regulation : there is more than meets the eye Paola Chiarugi pp.329-337

Gene discovery analysis from mouse embryonic stem cells based on time course microarray data Young Ju Suh ;Sun A Cho ;Jung Hee Shim ;Yeon Joo Yook ;Kyung Hyun Yoo ;Jung Hee Kim ;Eun Young Park pp.338-343

Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans Seongseop Kim ;Dae-Hun Park ;Jaegal Shim pp.344-349

Genetic screen for genes involved in Chk2 signaling in Drosophila Suk-Young Park ;Young-Han Song pp.350-355

Lamin A/C and polymeric actin in genome organization Vladan Ondrej ;Emilie Lukásová ;Jana Krejcí ;Pavel Matula ;Stanislav Kozubek pp.356-361

Identification of a cryptic type Ⅲ polyketide synthase(1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952 Gopal Prasad Ghimire ;Tae-Jin Oh ;Kwangkyoung Liou ;Jae Kyung Sohng pp.362-367

Functional conservation and divergence of FVE genes that control flowering time and cold response in rice and Arabidopsis Il-Sun Baek ;Hyo-Young Park ;Min Kyoung You ;Jeong Hwan Lee ;Jeong-Kook Kim pp.368-372

The photoreceptor populations in the retina of the greater horseshoe bat Rhinolophus ferrumequinum Tae-Jin Kim ;Young-Ki Jeon ;Jea-Young Lee ;Eun-Shil Lee ;Chang-Jin Jeon pp.373-379

Identification of osteogenic purmorphamine derivatives Sung-Jin Lee ;Hak-Kyo Lee ;Sung Yun Cho ;Joong-Kwon Choi ;Hea Kyeong Shin ;Eun-Jung Kwak ;Mi-Ran Cho pp.380-386

MMTS, a new subfamily of Tc1-like transposons Sang Jung Ahn ;Moo-Sang Kim ;Jae Ho Jang ;Sang Uk Lim ;Hyung Ho Lee pp.387-395

Activation of small GTPases RhoA and Rac1 is required for avian reovirus p10-induced syncytium formation Hung-Jen Liu ;Ping-Yuan Lin ;Ling-Rung Wang ;Hsue-Yin Hsu ;Ming-Huei Liao ;Wen-Ling Shih pp.396-403

Structural characterization of the genome of BERVγ4, the most abundant endogenous retrovirus family in cattle Rui Xiao ;Kwangha Park ;Younshin Oh ;Jinhoi Kim ;Chankyu Park pp.404-408

FXRα down-regulates LXRα signaling at the CETP promoter via a common element Sung-Soo Park ;Hojung Choi ;Seung-Jin Kim ;Ok Jin Kim ;Kwon-Seok Chae ;Eungseok Kim pp.409-414

참고문헌 (31건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Actions of hedgehog proteins on skeletal cells. 네이버 미소장
2 James, C.G., Appleton, C.T., Ulici, V., Underhill, T.M., and Beier, F. (2005). Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol. Biol. Cell 16, 5316-5333    미소장
3 The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. 네이버 미소장
4 Developmental control of chondrogenesis and osteogenesis. 네이버 미소장
5 Dedifferentiation of lineage-committed cells by a small molecule. 네이버 미소장
6 Gibert, S.F. (2006). Intramembranous ossification. Dev. Biol. 8th eds., 420-421 미소장
7 The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. 네이버 미소장
8 The world according to hedgehog 네이버 미소장
9 Multiple functions of Dlx genes. 네이버 미소장
10 Osteoblast Differentiation and Skeletal Development Are Regulated by Mdm2-p53 Signaling 네이버 미소장
11 Lee, J.S., Thomas, D.M., Gutierrez, G., Carty, S.A., Yanagawa, S., and Hinds, P.W. (2006). HES1 cooperates with pRb to activate RUNX2-dependent transcription. J. Bone Miner. Res. 21, 921- 933    미소장
12 DLX3 mutation in a new family and its phenotypic variations. 네이버 미소장
13 Hedgehog and beyond 네이버 미소장
14 Sapkota, G., Alarcon, C., Spagnoli, F.M., Brivanlou, A.H., and Massague, J. (2007). Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol. Cell 25, 441-454       미소장
15 The life cycle of chondrocytes in the developing skeleton. 네이버 미소장
16 Purmorphamine activates the Hedgehog pathway by targeting Smoothened. 네이버 미소장
17 Purmorphamine Induces Osteogenesis by Activation of the Hedgehog Signaling Pathway 네이버 미소장
18 Zinc-induced sodium-dependent vitamin C transporter 2 expression: potent roles in osteoblast differentiation 네이버 미소장
19 Smad1 and Smad5 Act Downstream of Intracellular Signalings of BMP-2 That Inhibits Myogenic Differentiation and Induces Osteoblast Differentiation in C2C12 Myoblasts 네이버 미소장
20 Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells 네이버 미소장
21 The new bone biology: pathologic, molecular, and clinical correlates. 네이버 미소장
22 Molecular ontogeny of the skeleton. 네이버 미소장
23 Fanganiello, R.D., Sertie, A.L., Reis, E.M., Yeh, E., Oliveira, N.A., Bueno, D.F., Kerkis, I., Alonso, N., Cavalheiro, S., Matsushita, H., et al. (2007). Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells. Mol. Med. 13, 422-442 미소장
24 Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors. 네이버 미소장
25 Karsenty, G., and Wagner, E.F. (2002). Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406    미소장
26 Developmental regulation of the growth plate 네이버 미소장
27 CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts. 네이버 미소장
28 Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. 네이버 미소장
29 Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation 네이버 미소장
30 Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells 네이버 미소장
31 A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. 네이버 미소장

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