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Single-channel recordings of TASK-1 and TASK-3, members of two-pore domain K+ channel family, have not yet been reported in dorsal root ganglion (DRG) neurons, even though their mRNA and activity in whole-cell currents have been detected in these neurons. Here, we report single-channel kinetics of the TASK-3-like K+ channel in DRG neurons and up-regulation of TASK-3 mRNA expression in tissues isolated from animals with spinal cord injury (SCI). In DRG neurons, the single-channel conductance of TASK-3-like K+ channel was 33.0±0.1 pS at ?60 mV, and TASK-3 activity fell by 65±5% when the extracellular pH was changed from 7.3 to 6.3, indicating that the DRG K+ channel is similar to cloned TASK-3 channel. TASK-3 mRNA and protein levels in brain, spinal cord, and DRG were significantly higher in injured animals than in sham-operated ones. These results indicate that TASK-3 channels are expressed and functional in DRG neurons and the expression level is up-regulated following SCI, and suggest that TASK-3 channel could act as a potential background K＋ channel under SCI-induced acidic condition.

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기사명 저자명 페이지 원문 목차
Role of glucocorticoids in fasting-induced changes in hypothalamic and pituitary components of the growth hormone (GH)-axis Eunhee Kim ;Sanghee Seo ;Hyunju Chung ;Seungjoon Park pp.217-223

Netrin-1 specifically enhances cell spreading on fibronectin in human glioblastoma cells Hyun Kyoung Lee ;In Ae Seo ;Yoon Kyung Shin ;Sang Hwa Lee ;Su-Young Seo ;Duk Joon Suh ;Hwan Tae Park pp.225-230

Heparin attenuates the expression of TNFα-induced cerebral endothelial cell adhesion molecule Jeong Ho Lee ;Chul Hoon Kim ;Gi Ho Seo ;Jinu Lee ;Joo Hee Kim ;Dong Goo Kim ;Young Soo Ahn pp.231-236

Spinal metabotropic glutamate receptors (mGluRs) are involved in the melittin-induced nociception in rats Chul Hyun Cho ;Hong Kee Shin pp.237-243

Single-channel recording of TASK-3-like K^+^ channel and up-regulation of TASK-3 mRNA expression after spinal cord injury in rat dorsal root ganglion neurons Inseok Jang ;Jun-Ho La ;Gyu-Tae Kim ;Jeong-Soon Lee ;Eun-Jin Kim ;Eun-Shin Lee ;Su-Jeong Kim ;Jeong- pp.245-251

Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats Sung Jun Jung ;Su-Hyun Jo ;Sanghyuck Lee ;Eunhui Oh ;Min-Seok Kim ;Woo Dong Nam ;Seog Bae Oh pp.253-258

PKC-independent stimulation of cardiac Na^+^/Ca^2+^ exchanger by staurosporine Tong Mook Kang pp.259-265

Modeling of arrhythmogenic automaticity induced by stretch in rat atrial myocytes Jae Boum Youm ;Chae Hun Leem ;Yin Hua Zhang ;Nari Kim ;Jin Han ;Yung E. Earm pp.267-274

Kinetic changes of COX-2 expression during reperfusion period after ischemic preconditioning play a role in protection against ischemic damage in rat brain Young Jin Kang ;Min Kyu Park ;Hyun Suk Lee ;Hyoung Chul Choi ;Kwang Youn Lee ;Hye Jung Kim ;Han Geuk pp.275-280

Tyrphostin ErbB2 inhibitors AG825 and AG879 have non-specific suppressive effects on gp130/ STAT3 signaling Hyun Kyoung Lee ;In Ae Seo ;Sang Hwa Lee ;Su-Young Seo ;Kyung Sup Kim ;Hwan Tae Park pp.281-286

참고문헌 (19건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 A sensitive and reliable locomotor rating scale for open field testing in rats. 네이버 미소장
2 Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism. 네이버 미소장
3 Cooper BY, Johnson RD, Rau KK. Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell. Neuroscience 129: 209−224, 2004 미소장
4 Effects of Methylprednisolone on Extracellular Lactic Acidosis and Amino Acids After Severe Compression Injury of Rat Spinal Cord 네이버 미소장
5 Acid-sensitive ion channels in gastrointestinal function 네이버 미소장
6 Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. 네이버 미소장
7 Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells. 네이버 미소장
8 Single-channel properties and pH sensitivity of two-pore domain K + channels of the TALK family 네이버 미소장
9 Kang D, Kim D. TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons. Am J Physiol Cell Physiol 291: C138−146, 2006 미소장
10 Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family. 네이버 미소장
11 Fatty acid-sensitive two-pore domain K + channels 네이버 미소장
12 A novel acid-sensitive K + channel in rat dorsal root ganglia neurons 네이버 미소장
13 Repair of the descending thoracic aorta: impact of open distal anastomosis technique on spinal cord perfusion, neurological outcome and spinal cord histopathology 네이버 미소장
14 Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery 네이버 미소장
15 Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons. 네이버 미소장
16 Expression of TWIK-related acid sensitive K + channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia 네이버 미소장
17 Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. 네이버 미소장
18 Pharmacological characterization of ionic currents that regulate high-frequency spontaneous activity of electromotor neurons in the weakly electric fish, Apteronotus leptorhynchus. 네이버 미소장
19 Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons 네이버 미소장

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