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Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fact, earlier pharmacological studies have provided results that support either a facilitatory or inhibitory role for SOM in nociception. In the current study, the effects of SOM were investigated using anesthetized cats. Specifically, the responses of rostrally projecting spinal dorsal horn neurons (RPSDH neurons) to different kinds of noxious stimuli (i.e., heat, mechanical and cold stimuli) and to the Aδ-and C-fiber activation of the sciatic nerve were studied. Iontophoretically applied SOM suppressed the responses of RPSDH neurons to noxious heat and mechanical stimuli as well as to C-fiber activation. Conversely, it enhanced these responses to noxious cold stimulus and Aδ-fiber activation. In addition, SOM suppressed glutamate-evoked activities of RPSDH neurons. The effects of SOM were blocked by the SOM receptor antagonist cyclo-SOM. These findings suggest that SOM has a dual effect on the activities of RPSDH neurons; that is, facilitation and inhibition, depending on the modality of pain signaled through them and its action site.

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기사명 저자명 페이지 원문 목차
Role of glucocorticoids in fasting-induced changes in hypothalamic and pituitary components of the growth hormone (GH)-axis Eunhee Kim ;Sanghee Seo ;Hyunju Chung ;Seungjoon Park pp.217-223

Netrin-1 specifically enhances cell spreading on fibronectin in human glioblastoma cells Hyun Kyoung Lee ;In Ae Seo ;Yoon Kyung Shin ;Sang Hwa Lee ;Su-Young Seo ;Duk Joon Suh ;Hwan Tae Park pp.225-230

Heparin attenuates the expression of TNFα-induced cerebral endothelial cell adhesion molecule Jeong Ho Lee ;Chul Hoon Kim ;Gi Ho Seo ;Jinu Lee ;Joo Hee Kim ;Dong Goo Kim ;Young Soo Ahn pp.231-236

Spinal metabotropic glutamate receptors (mGluRs) are involved in the melittin-induced nociception in rats Chul Hyun Cho ;Hong Kee Shin pp.237-243

Single-channel recording of TASK-3-like K^+^ channel and up-regulation of TASK-3 mRNA expression after spinal cord injury in rat dorsal root ganglion neurons Inseok Jang ;Jun-Ho La ;Gyu-Tae Kim ;Jeong-Soon Lee ;Eun-Jin Kim ;Eun-Shin Lee ;Su-Jeong Kim ;Jeong- pp.245-251

Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats Sung Jun Jung ;Su-Hyun Jo ;Sanghyuck Lee ;Eunhui Oh ;Min-Seok Kim ;Woo Dong Nam ;Seog Bae Oh pp.253-258

PKC-independent stimulation of cardiac Na^+^/Ca^2+^ exchanger by staurosporine Tong Mook Kang pp.259-265

Modeling of arrhythmogenic automaticity induced by stretch in rat atrial myocytes Jae Boum Youm ;Chae Hun Leem ;Yin Hua Zhang ;Nari Kim ;Jin Han ;Yung E. Earm pp.267-274

Kinetic changes of COX-2 expression during reperfusion period after ischemic preconditioning play a role in protection against ischemic damage in rat brain Young Jin Kang ;Min Kyu Park ;Hyun Suk Lee ;Hyoung Chul Choi ;Kwang Youn Lee ;Hye Jung Kim ;Han Geuk pp.275-280

Tyrphostin ErbB2 inhibitors AG825 and AG879 have non-specific suppressive effects on gp130/ STAT3 signaling Hyun Kyoung Lee ;In Ae Seo ;Sang Hwa Lee ;Su-Young Seo ;Kyung Sup Kim ;Hwan Tae Park pp.281-286

참고문헌 (47건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 The periaqueductal gray-raphe magnus projection contains somatostatin, neurotensin and serotonin but not cholecystokinin 네이버 미소장
2 Tonic control of peripheral cutaneous nociceptors by somatostatin receptors. 네이버 미소장
3 The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord 네이버 미소장
4 The effect of epidural somatostatin on postoperative pain. 네이버 미소장
5 Electrophysiological effects of somatostatin-14 and somatostatin-28 on mammalian central nervous system neurons 네이버 미소장
6 Fruhstorfer H, Zenz M, Notle H, Hensel H. Dissociated loss of cold and warm sensibility during regional anesthesia. Pflügers Arch 349: 73−82, 1974 미소장
7 Opiate and peptide inhibition of transmitter release in parasympathetic nerve terminals. 네이버 미소장
8 Somatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat. 네이버 미소장
9 Inhibition of spinal nociceptive neurons by microinjections of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anesthetized cat 네이버 미소장
10 Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat 네이버 미소장
11 An immunohistochemical study of neuronal populations containing neuropeptides or γ-aminobutyrate within the superficial layers of the rat dorsal horn 네이버 미소장
12 Somatostatin directly inhibits substantia gelatinosa neurons in adult rat spinal dorsal horn in vitro 네이버 미소장
13 Nociceptive responses to intrathecally administered substance P and somatostatin in diabetic mice 네이버 미소장
14 Kamei J, Hitosugi H, Misawa M, Nagase H, Kasuya Y. Cold water swim stress inhibits the nociceptive responses to intrathecally administered somatostatin, but not substance P. Life Sci 52 PL169−174, 1993 미소장
15 Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats 네이버 미소장
16 Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. 네이버 미소장
17 Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn 네이버 미소장
18 Evidence for dorsal root projection to somatostatin-immunoreactive structures in laminae I-II of the spinal dorsal horn. 네이버 미소장
19 Golgi impregnated somatostatin immunoreactive neurons in lamina II of the rat spinal cord 네이버 미소장
20 Meynadier J, Chrubasik J, Dubar M, Wünsch E. Intrathecal somatostatin in terminally ill patients. A report of two cases. Pain 23: 9−12, 1985 미소장
21 Neurons of the ventral medulla oblongata that contain both somatostatin and enkephalin immunoreactivities project to nucleus tractus solitarii and spinal cord 네이버 미소장
22 Antinociceptive and ‘neurotoxic’ actions of somatostatin in rat spinal cord after intrathecal administration 네이버 미소장
23 Morton CR, Hutchison WD, Hendry IA, Duggan AW. Somatostatin: evidence for a role in thermal nociception. Brain Res 488: 89−96, 1989 미소장
24 The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: an intracellular study 네이버 미소장
25 Modality-specific antinociception produced by intrathecal injection of anti-somatostatin antiserum in rats 네이버 미소장
26 Neurosurgery 네이버 미소장
27 Somatostatin and Its Receptor Family 네이버 미소장
28 Octreotide: a potent new non-opiate analgesic for intrathecal infusion. 네이버 미소장
29 Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia. 네이버 미소장
30 Rang HP, Bevan S, Dray A. Nociceptive peripheral neurons: cellular properties. In: Wall PD, Melzack R eds, Textbook of Pain. 3rd ed. Churchill Livingstone, Edinburgh (UK), p 57−78, 1994 미소장
31 Robbins R. Somatostatin and the cerebral cortex. In: Patel YC, Tanneum GS eds, Somatostatin, Plenum, New York, p 201−216, 1985 미소장
32 Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: Comparison with spinal morphine 네이버 미소장
33 Somatostatin peptides inhibit basolateral potassium channels in human colonic crypts. 네이버 미소장
34 Intrathecal substance P and somatostatin in rats: Behaviors indicative of sensation 네이버 미소장
35 Pain relief by somatostatin in attacks of cluster headache 네이버 미소장
36 Simone DA, Kajander KC. Responses of cutaneous A-fiber nociceptors to noxious cold. J. Neurophysiol 77: 2049−2060, 1997 미소장
37 Spinal Somatostatin SSTR2A Receptors Are Preferentially Up-regulated and Involved in Thermonociception but Not Mechanonociception 네이버 미소장
38 Evidence for ascending and descending intraspinal as well as primary sensory somatostatin projections in the rat spinal cord. 네이버 미소장
39 Selective Opioid Inhibition of Small Nociceptive Neurons 네이버 미소장
40 Traub RJ, Brozoski D. Anti-somatostatin antisera, but neither a somatostatin agonist (octreotide) nor antagonist (CYCAM), attenuates hyperalgesia in the rat. Peptides 17: 769−773, 1996 미소장
41 Effect of intrathecal octreotide on thermal hyperalgesia and evoked spinal c-Fos expression in rats with sciatic constriction injury 네이버 미소장
42 Immunohistochemical studies of substance P, cholecystokinin-octapeptide and somatostatin in dorsal root ganglia of the rat 네이버 미소장
43 Wang H, Bogen C, Reisine T, Dichter M. SRIF-14 and SRIF-28 induce opposite effects on potassium currents in rat neocortical neurons. Proc Natl Acad Sci USA 86: 9616−9620, 1989. 미소장
44 Intrathecal somatostatin modulates spinal sensory and reflex mechanisms: Behavioral and electrophysiological studies in the rat 네이버 미소장
45 Substance P and somatostatin modulate spinal cord excitability via physiologically different sensory pathways 네이버 미소장
46 Willis WD, Coggeshall RE. The sensory channel. In: Willis WD, Coggeshall RE eds, Sensory Mechanisms of the Spinal Cord. 2nd ed. Plenum Press, New York, p 449−456, 1991 미소장
47 A novel slow excitatory postsynaptic current in substantia gelatinosa neurons of the rat spinal cord in vitro 네이버 미소장

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