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The present study was performed to investigate the binding affinity of the ethanol extract from the

leaves of Morus alba (EMA) and some EMA related plant materials (EMA-D, EMA-DM) for melaninconcentrating

hormone-1 receptor (MCH-1) and also to examine the antagonistic effect of them for the

recombinant MCH-1 receptor expressed in CHO cells. EMA, dichloromethane fraction (EMA-D) and EMA-DM

exhibited high affinity for mammalian MCH receptor in receptor binding assays (IC50 value: 2.3, 1.6 and 1.0 킽/

ml, respectively). Other plant materials (MMA-D, MMA-DM) obtained from methanol extracts from the leaves

of Morus alba (MMA) also exhibited high affinity for mammalian MCH receptor, even though the IC50 values of

them were lower than those of EMA-D and EMA-DM. In Chinese hamster ovary (CHO) cells expressing human

MCH-1, EMA-DM and EMA-D significantly inhibited MCH-induced intracellular Ca2+ increase (IC50 values:

16.5 and 22.7 킽/ml, respectively). These results clearly indicate that the ethanol extract from the leaves of Morus

alba (EMA) and some EMA related plant materials (EMA-D, EMA-DM) are novel selective MCH-1 receptor

antagonist, respectively.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Cell growth inhibitory effect of tissue cultured root of wild Panax ginseng C.A. mayer extract on various cancer cell lines Jeong Sook Park ;Tae Woong Lee ;Kun Han pp.1-7

Comparison of glucose tolerance effect of various commelinaceae plant extracts on hyperglycemic rats Ju Chan Kwon ;Seung Heon Lee ;Sandesh Sancheti ;Shruti Sancheti ;Mie Young Choi ;SungYum Seo pp.8-11

Phytochemical constituents from Metasequoia glyptostroboids leaves Chao Hui Duan ;Jung Noh Lee ;Chung Mong Lee ;Ghang Tai Lee ;Kun Kook Lee pp.12-16

Lignans from the roots of Berberis amurensis Hyun Bong Park ;Kyu Ha Lee ;Ki Hyun Kim ;Il Kyun Lee ;Hyung Jun Noh ;Sang Un Choi ;Kang Ro Lee pp.17-21

A new naphthoquinone with anti-inflammatory activity from an Egyptian collection of Echiochilon fruticosum Hoda M. Fathy ;Mohamed I. Aboushoer ;Azza Baraka ;Maged S. Abdel-Kader ;Abdallah A. Omar pp.22-26

Melanin-concentrating hormone-1 receptor (MCH-1) antagonism of the leaves extract from Morus alba Byung Koo Oh ;Kwang-Seok Oh ;Sunghou Lee ;Ho Won Seo ;Yeon Hee Choi ;Jae Seok Choi ;Young Sup Kim ;B pp.27-31

Effects of curcumin, the active ingredient of turmeric (Curcuma longa), on regulation of glutamate-induced toxicity and activation of the mitogen-activated protein kinase phosphatase-1 (MKP-1) in HT22 neuronal cells Sang-Hyun Lee ;Young-Gab Yun pp.32-36

Phaleria macrocarpa suppresses oxidatives stress in alloxan-induced diabetic rats by enhancing hepatic antioxidant enzyme activity Asih Triastuti ;Hee-Juhn Park ;Jongwon Choi pp.37-43

Phytochemical constituents of Amomum xanthioides Jung Wook Choi ;Ki Hyun Kim ;Il Kyun Lee ;Sang Un Choi ;Kang Ro Lee pp.44-49

Quantitative determination of diterpenoids from the roots of Aralia cordata Mi Kyoung Lee ;Tran Manh Hung ;Byung-Sun Min ;IkSoo Lee ;MinKyun Na ;Mi Hee Woo ;Jong Keun Son ;Youn pp.50-54

참고문헌 (12건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice 네이버 미소장
2 The discovery and optimization of pyrimidinone-containing MCH R1 antagonists 네이버 미소장
3 A dministration of Folium mori Extract Decreases Nitric Oxide Synthase Expression in the Hypothalamus of Streptozotocin-Induced Diabetic Rats 네이버 미소장
4 Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. 네이버 미소장
5 The relationship of obesity to the metabolic syndrome. 네이버 미소장
6 Development of a time-resolved fluorometric assay for the high throughput screening of melanin concentrating hormone receptor antagonists 네이버 미소장
7 Reduction of risk factors for cardiovascular diseases in morbid-obese patients following biliary-intestinal bypass: 3 years' follow-up 네이버 미소장
8 Melanin-concentrating hormone: from fish skin to skinny mammals 네이버 미소장
9 Biphasic effects of Morus alba leaves green tea extract on mice in chronic forced swimming model. 네이버 미소장
10 Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats 네이버 미소장
11 Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice 네이버 미소장
12 Evaluation of FLIPR Calcium 3 Assay Kit--a new no-wash fluorescence calcium indicator reagent. 네이버 미소장

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