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부분방광출구폐색 후 비마취하 흰쥐의 요역동학검사 결과에서 폐색과 과민성방광 모델로서의 적용과 한계점 / 박수환 ; 김룡호 ; 권용현 ; 윤상민 ; 류지간 ; 이택 1
[요약] 1
서론 1
대상 및 방법 2
1. 실험동물 2
2. 부분적 방광출구폐색 2
3. 방광내관 및 복압측정기구 삽입법 2
4. 방광 내압 측정을 위한 기구 2
5. 요역동학검사의 측정변수들 2
6. 자료 분석 및 통계 3
결과 3
1. 요역동학검사 시행도중 폐색군에서 관찰된 문제점 3
2. 방광의 무게 변화 3
3. 배뇨압력 및 부피 변수들의 비교 3
4. 과민성방광 지표의 변화 4
고찰 5
결론 6
REFERENCES 6
초록보기
Purpose: Partial bladder outlet obstruction (PBOO) in rats leads to changes in bladder function, such as obstruction and detrusor overactivity (DO). The aim of our study was to observe factors essential for the objective descriptions of PBOO rats as an overactive bladder model as well as an obstruction model under awake cystometry. We also aimed to investigate the urodynamic effects of PBOO objectively in view of DO-related parameters as well as conventional pressure and volume-related parameters.
Materials and Methods: PBOO was produced in 10 female Sprague- Dawley rats by ligating the proximal urethra over a 0.9 mm metal rod; 10 sham-operated rats were used as controls. Intravesical pressure (IVP) was recorded via an open catheter in the bladder, and intraabdominal pressure (IAP) via an intraabdominal balloon catheter. Continuous cystometry was performed 2 weeks after the PBOO procedure. Conventional and newly developed DO-related urodynamic parameters were investigated.
Results: PBOO led to a significant increase in bladder weight. Three rats showed the picture of decompensated bladder and were excluded from the analysis. The obstructed group showed some increased pressure- and volume-related parameters. They showed a DO frequency of 1.5?.3/min, but the sham group did not.
Conclusions: Our results showed that bladder decompensation can happen after PBOO, and we need to describe those exclusions accurately in reports. In conscious PBOO rats, simultaneous registration of IAP and IVP is needed for accurate investigations of DO, because PBOO can lead to DO as well as bladder hypertrophy.권호기사
참고문헌 (21건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Determinants of treatment-seeking behaviour for urinary symptoms in older men.  |
미소장 |
| 2 | BPH with coexisting overactive bladder dysfunction—an everyday urological dilemma |
미소장 |
| 3 | The Urodynamic Findings of Male Patients with LUTS and the Effects of the Pre-operative Parameters on the Outcome of Transurethral Resection of the Prostate |
미소장 |
| 4 | de Groat WC. A neurologic basis for the overactive bladder. Urology 1997;50(6A Suppl):36-52 | 미소장 |
| 5 | Cystometrical evaluation of acute and chronic overdistension in the rat urinary bladder. |
미소장 |
| 6 | The Guinea Pig as a Model of Gradual Urethral Obstruction |
미소장 |
| 7 | Collagen prolyl 4-hydroxylase is up-regulated in an acute bladder outlet obstruction |
미소장 |
| 8 | Compliance of the obstructed fetal rabbit bladder. |
미소장 |
| 9 | Acute Biochemical and Functional Alterations in The Partially Obstructed Rabbit Urinary Bladder |
미소장 |
| 10 | Short term functional effects of bladder outlet obstruction in the cat. |
미소장 |
| 11 | The detrusor muscle: an innocent victim of bladder outlet obstruction. |
미소장 |
| 12 | Effect of Bladder Outlet Obstruction on Micturition Reflex Pathways in the Rat |
미소장 |
| 13 | Genetic and cellular characteristics of bladder outlet obstruction. |
미소장 |
| 14 | EXPERIMENTAL BLADDER INSTABILITY FOLLOWING BLADDER OUTLET OBSTRUCTION IN THE FEMALE RAT |
미소장 |
| 15 | Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies. |
미소장 |
| 16 | Brading AF. A myogenic basis for the overactive bladder. Urology 1997;50:57-67 | 미소장 |
| 17 | Elbadawi A, Yalla SV, Resnick NM. Structural basis of geriatric voiding dysfunction. IV. Bladder outlet obstruction. J Urol 1993;150:1681-95 | 미소장 |
| 18 | Volume‐induced effects on the isolated bladder: a possible local reflex |
미소장 |
| 19 | Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats--effects of bladder outlet obstruction and intravesical PGE2. |
미소장 |
| 20 | The Value and Limitations of Intravesical Prostaglandin E2 (PGE2)-induced Bladder Hyperactivity as an Overactive Bladder Model in Normal, Conscious Sprague-Dawley Rats | 소장 |
| 21 | Neurally mediated hyperactive voiding in spontaneously hypertensive rats |
미소장 |
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