본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Neurodegenerative diseases are highly morbid and widespread in the nation with aged population. Since these are progressive and irreversible diseases, early detection and differentiation of the disease are important for possible therapeutic intervention. Alzheimer's disease and Parkinson's disease are the most frequent and costly devastating neurodegenerative diseases. Recent advances of molecular imaging, especially positron emission tomography (PET) technique, allows non-invasive evaluation of not only regional cerebral metabolism or perfusion, but also the change of neurotransmission and presence of abnormal protein such as beta amyloid. In Parkinsonism, dopamine transporter and vesicular monoamine transporter imaging are useful in the diagnosis and evaluation of the disease progression since these provide information about the integrity of presynaptic striatal dopaminergic neurons. In Alzheimer's disease, beta-amyloid imaging can assess the amyloid deposition. It improves early diagnosis and possibility of a presymptomatic diagnostic biomarker; improves understanding of the natural history of amyloid deposition; and has the capability to directly measure the effects of newly developed anti-amyloid therapies. Cholinergic and microglial imaging can be also useful in the early diagnosis of dementia and improves understanding of insights into pathophysiology of neurodegenerative diseases. Therefore, the ability of molecular imaging to identify and quantify cerebral pathology has significant implications for early detection, differential diagnosis, and therapeutic monitoring in neurodegenerative diseases.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
자유무역시대 의사의 역할 :기회와 위기 손명세 pp.110-111

양전자 방출 촬영을 이용한 암 대사 영상 윤미진 ;이종두 pp.113-120

종양 표적 자기공명 분자영상 송호택 ;서진석 pp.121-124

분자영상을 위한 다기능성 나노입자 강은아 ;김광명 ;권익찬 pp.125-134

혈관신생에 대한 분자영상 이경한 pp.135-142

동맥경화 분자영상 김동억 ;정상욱 pp.143-150

퇴행성 뇌질환에서의 분자영상 김재승 ;오승준 ;문대혁 pp.151-167

인공혈액의 현재와 전망 :적혈구 대용제제를 중심으로 김종훈 ;이기영 pp.168-181

뇌기능 영상 장치를 이용한 통증의 연구 배선준 ;조장희 ;이배환 pp.182-188

미숙아 치료에서 새로 개발된 약제들 배종우 pp.191-198

참고문헌 (107건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum. 네이버 미소장
2 Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K,- Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 1973; 20: 415-455. 미소장
3 Functional imaging in relation to parkinsonian syndromes. 네이버 미소장
4 Neumeyer JL, Wang S, Gao Y, Milius RA, Kula NS, Campbell A, Baldessarini RJ, Zea-Ponce Y, Baldwin Innis RB. RM,N- α Fluoroalkyl analogs of (1R)-2β- carbomethoxy-3β- (4-iodophenyl)- tropane (β- CIT): Radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporter. J Med Chem 1994; 37: 1558-1561. 미소장
5 SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. 네이버 미소장
6 [18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: Biodistribution in rats 네이버 미소장
7 Huang WS, Lee MS, Lin JC, Chen CY, Yang YW, Lin SZ, Wey SP. Usefulness of brain 99mTc-TRODAT-1 SPET for the evaluation of Parkinson's disease. Eur J Nucl Med Mol Imaging 2004; 31: 155-161. 미소장
8 Kim HJ, Im JH, Yang SO, Moon DH, Ryu JS, Bong JK, Nam KP, Cheon JH, Lee MC, Lee hK. Imaging and quantitation of dopamine transporters with iodine-123- IPT in normal and Parkinson's disease subjects. J Nucl Med 1997; 38: 1703- 1711. 미소장
9 [18F] beta-CIT-FP is superior to [11C] beta-CIT-FP for quantitation of the dopamine transporter. 네이버 미소장
10 One-step high-radiochemical-yield synthesis of [ 18F]FP-CIT using a protic solvent system 네이버 미소장
11 Dopamine transporter imaging with fluorine-18-FPCIT and PET. 네이버 미소장
12 Parametric mapping of [18F]FPCIT binding in early stage Parkinson's disease: A PET study 네이버 미소장
13 [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease. 네이버 미소장
14 Usefulness of a dopamine transporter PET ligand [(18)F]beta-CFT in assessing disability in Parkinson's disease. 네이버 미소장
15 AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY 네이버 미소장
16 Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT: binding kinetics and effects of normal aging. 네이버 미소장
17 Effects of age on dopamine transporters in healthy humans. 네이버 미소장
18 Effect of age and gender on dopamine transporter imaging with [^1^2^3I]FP-CIT SPET in healthy volunteers 네이버 미소장
19 Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study 네이버 미소장
20 Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. 네이버 미소장
21 Levodopa and the progression of Parkinson's disease. 네이버 미소장
22 Essential tremor course and disability: a clinicopathologic study of 20 cases. 네이버 미소장
23 Isolated tremor and disruption of the nigrostriatal dopaminergic system: an 18F-dopa PET study. 네이버 미소장
24 Accuracy of diagnosis in patients with presumed Parkinson's disease. 네이버 미소장
25 Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. 네이버 미소장
26 Long duration asymmetrical postural tremor is likely to predict development of Parkinson's disease and not essential tremor: clinical follow up study of 13 cases. 네이버 미소장
27 Varrone A, Marek KL, Jennings D, Innis RB, Seibyl JP. [1231I]- CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson s disease and multiple system atrophy. Mov Disord 2001; 16: 1023- 1032. 미소장
28 Antonini A, Benti R, De Notaris R, Tesei S, Zecchinelli A, Sacilotto G, Meucci N, Canesi M, Mariani C, Pezzoli G, Gerundini P. 123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson s disease, multiple system atrophy, and progressive supranuclear palsy. Neurol Sci 2003; 24: 149-150. 미소장
29 Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients 네이버 미소장
30 Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease 네이버 미소장
31 Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysis. 네이버 미소장
32 ARTERIOSCLEROTIC PARKINSONISM 네이버 미소장
33 Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis 네이버 미소장
34 [123I]β‐CIT SPECT distinguishes vascular parkinsonism from Parkinson's disease 네이버 미소장
35 123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism. 네이버 미소장
36 Asymmetry of neuroleptic-induced rigidity: Development of quantitative methods and clinical correlates 네이버 미소장
37 Dopamine transporter density in young patients with schizophrenia assessed with [123]FP-CIT SPECT. 네이버 미소장
38 Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. 네이버 미소장
39 Merdes AR, Hansen LA, Jeste DV, Galasko D, Hofstetter CR, Ho GJ, Thal LJ, Corey-Bloom J. Influenceof Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology 2003; 60: 1586 - 1590. 미소장
40 Eerola J, Tienari PJ, Kaakkola S, Nikkinen P, Launes J. How useful is [123I]-CIT SPECT in clinical practice? J Neurol Neurosurg Psychiatry 2005; 76: 1211-1216. 미소장
41 Dementia with Lewy bodies versus Alzheimer's disease: Role of dopamine transporter imaging 네이버 미소장
42 Idiopathic hyposmia as a preclinical sign of Parkinson's disease 네이버 미소장
43 Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT 네이버 미소장
44 Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. 네이버 미소장
45 Alzheimer's disease: genes, proteins, and therapy. 네이버 미소장
46 NEUROPATHOLOGY OF ALZHEIMER'S DISEASE AND RELATED DISORDERS 네이버 미소장
47 The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes. 네이버 미소장
48 Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles. 네이버 미소장
49 Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. 네이버 미소장
50 Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids 네이버 미소장
51 The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease 네이버 미소장
52 Neuropathology of cognitively normal elderly. 네이버 미소장
53 Physiological roles for amyloid beta peptides. 네이버 미소장
54 Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. 네이버 미소장
55 F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Abeta aggregates in the brain. 네이버 미소장
56 Peripheral metabolism of [ 18F]FDDNP and cerebral uptake of its labelled metabolites 네이버 미소장
57 Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B 네이버 미소장
58 Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, Dekosky ST, Mathis CA. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 2005; 25: 1528-1547. 미소장
59 In-Vivo Imaging of Alzheimer Disease beta-Amyloid With [^1^1C]SB-13 PET 네이버 미소장
60 PET of brain amyloid and tau in mild cognitive impairment. 네이버 미소장
61 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. 네이버 미소장
62 PET imaging of amyloid deposition in patients with mild cognitive impairment 네이버 미소장
63 Frequent amyloid deposition without significant cognitive impairment among the elderly. 네이버 미소장
64 [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. 네이버 미소장
65 Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease 네이버 미소장
66 Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. 네이버 미소장
67 Current progress in beta-amyloid immunotherapy 네이버 미소장
68 Blokland A. Acetylcholine: A Neurotransmitter for Learning and Memory? Brain Res Rev 1996; 21: 285-300. 미소장
69 Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6) 네이버 미소장
70 Cholinergic innervation in the human hippocampal formation including the entorhinal cortex. 네이버 미소장
71 Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology 네이버 미소장
72 Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter. 네이버 미소장
73 Improved synthesis and radiolabeling of [11C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET. 네이버 미소장
74 Synthesis of 1-[ 11c]methylpiperidin-4-yl propionate ([ 11c]pmp) for in vivo measurements of acetylcholinesterase activity 네이버 미소장
75 SPET imaging of central muscarinic receptors with ( R, R)[ 123I]-I-QNB: methodological considerations 네이버 미소장
76 An improved method for rapid and efficient radioiodination of iodine-123-IQNB. 네이버 미소장
77 Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease 네이버 미소장
78 In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. 네이버 미소장
79 Brain Acetylcholinesterase Activity in Alzheimer Disease Measured by Positron Emission Tomography 네이버 미소장
80 Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease 네이버 미소장
81 Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. 네이버 미소장
82 Cerebral acetylcholine esterase activity in mild cognitive impairment. 네이버 미소장
83 Kinetic Analysis of Regional (S)(-)11C-Nicotine Binding in Normal and Alzheimer Brains In Vivo Assessment Using Positron Emission Tomography 네이버 미소장
84 Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex 네이버 미소장
85 Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease. 네이버 미소장
86 Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. 네이버 미소장
87 Imaging of Nicotinic and Muscarinic Receptors in Alzheimer's Disease: Effect of Tacrine Treatment 네이버 미소장
88 Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. 네이버 미소장
89 Microglia: Intrinsic immuneffector cell of the brain 네이버 미소장
90 Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta. 네이버 미소장
91 Microglia as mediators of inflammatory and degenerative diseases. 네이버 미소장
92 Occurrence of HLA-DR reactive microglia in Alzheimer's disease. 네이버 미소장
93 Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. 네이버 미소장
94 Modulation of human microglial cell superoxide production by cytokines. 네이버 미소장
95 Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation. 네이버 미소장
96 Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1 네이버 미소장
97 Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. 네이버 미소장
98 High densities of benzodiazepine receptors in human cortical areas. 네이버 미소장
99 Peripheral benzodiazepine receptors and mitochondrial function 네이버 미소장
100 Isolation of the Mitochondrial Benzodiazepine Receptor: Association with the Voltage-Dependent Anion Channel and the Adenine Nucleotide Carrier 네이버 미소장
101 Shah F, Hume SP, Pike VW, Ashworth S, McDermott J. Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol 1994; 21: 573-581. 미소장
102 Yu W, Wang E, Voll RJ, Millerb AH, Goodman MM. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioor Med Chem 2008;16: 6145-6155. 미소장
103 In-vivo measurement of activated microglia in dementia 네이버 미소장
104 PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease. 네이버 미소장
105 Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, Hammers A, Eggert K, Oertel W, Banati RB, Brooks DJ. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson s disease. Neurobiol Dis 2006; 21: 404- 412. 미소장
106 Ishizawa K, Dickson DW. Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration J Neuropathol Exp Neurol 2001; 60: 647- 657. 미소장
107 Gerhard A, Banati RB, Goerres GB, Cagnin A, Myers R, Gunn RN, Turkheimer F, good CD, Mathias CJ, Quinn N, Schwarz J, Brooks DJ. [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology 2003; 61: 686- 689. 미소장

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기