본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

The neuropeptide α-melanocyte-stimulating hormone (α-

MSH) has anti-inflammatory property by downregulating

the expressions of proinflammatory cytokines. Because

α-MSH elicits the anti-inflammatory effect in various

inflammatory disease models, we examined the therapeutic

effect of oral administration of recombinant Lactobacillus

casei, which secretes α-MSH (L. casei-α-MSH), on dextran

sulfate sodium (DSS)-induced colitis in Balb/c mice. Thus,

we constructed the α-MSH-secreting Lactobacillus casei

by the basic plasmid, pLUAT-ss, which was composed of a

PldhUTLS promoter and α-amylase signal sequence from

Streptococcus bovis strain. Acute colitis was induced by

oral administration of 5% DSS in drinking water for 7

days. To investigate the effect of L. casei-α-MSH on the

colitis, L. casei or L. casei-α-MSH was orally administered

for 7 days and their effects on body weight, mortality rate,

cytokine production, and tissue myeloperoxidase (MPO)

activity were observed. Administration of L. casei-α-MSH

reduced the symptom of acute colitis as assessed by

body weight loss (DSS alone: 14.45±0. 2 g; L. casei-α-

MSH: 18.2±0.12 g), colitis score (DSS alone: 3.6±0.4;

L. casei-α-MSH: 1.4±0.6), MPO activity (DSS alone:

42.7±4.5 U/g; L. casei-α-MSH: 10.25±0.5 U/g), survival

rate, and histological damage compared with the DSS

alone mice. L. casei-α-MSH-administered entire colon

showed reduced in vitro production of proinflammatory

cytokines and NF-κB activation. The α-MSH-secreting

recombinant L. casei showed significant anti-inflammatory

effects in the murine model of acute colitis and suggests a

potential therapeutic role for this agent in clinical

inflammatory bowel diseases.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Identification of psychrophile Shewanella sp. KMG427 as an eicosapentaenoic acid producer Lee, Won-Hae ;Ki-Woong Cho ;Soo-Young Park ;Kee-Sun Shin ;Dong-Sun Lee ;Seon-Kap Hwang ;Seok-Jong Se pp.1869-1873

Culture-independent analysis of microbial succession during composting of swine slurry and mushroom cultural wastes Cho, Kye Man ;Sun Mi Lee ;Renukaradhya K. Math ;Shah Md. Asraful Islam ;Devaiah M. Kambiranda ;Jong pp.1874-1883

Involvement of β-lactamase inhibitory protein, BLIP-Ⅱ, in morphological differentiation of Streptomyces exfoliatus SMF19 Kim, Eun Sook ;Ju Yeon Song ;Dae Wi Kim ;Eun Ji Ko ;Susan E. Jensen ;Kye Joon Lee pp.1884-1889

Influence of deletions in the apoemulsan gene cluster on Acinetobacter venerianus RAG-1 polysaccharide biosynthesis Dams-Kozlowska, Hanna ;Michael P. Mercaldi ;Aruranie Ramjeawan ;David L Kaplan pp.1890-1894

Proteome analysis for 3T3-L1 adipocyte differentiation Atiar Rahman, Md ;Suresh. G. Kumar ;Sung Hak Lee ;Hee Sun Hwang ;Hyun Ah Kim ;Jong Won Yun pp.1895-1902

Statistical optimization of medium components for the production of prodigiosin by Hahella chejyensis KCTC 2396 Kim, Sung Jin ;Hong Kum Lee ;Joung Han Yim pp.1903-1907

Isolation and physiological characterization of Bacillus clausii SKAL-16 isolated from wastewater Lee, Sung Hun ;Doo Hyun Park pp.1908-1914

Laboratory and field evaluations of entomopathogenic Lecanicillium attenuatum CNU-23 for control of green peach aphid(Myzus persicae) Kim, Hyang Yeon ;Hyang Burm Lee ;Young Cheol Kim ;In Seon Kim pp.1915-1918

Statistical optimization of the growth factors Chaetoceros neogracile using fractional factorial design and central composite design Jeong, Sung-Eun ;Jae-Kweon Park ;Jeong-Dong Kim ;In-Jeong Chang ;Seong-Joo Hong ;Sung-Ho Kang ;Choul pp.1919-1926

Optimization of the process for biodiesel production using a mixture of immobilized Rhizopus oryzae and Candida rugosa lipases Lee, Jong Ho ;Dong Hwan Lee ;Joong Soo Lim ;Byung-Hwan Um ;Chulhwan Park ;Seong Woo Kang ;Seung Wook pp.1927-1931

Improvement of amidase production by a newly isolated Delftia tsuruhatensis ZJB-05174 through optimization of culture medium Wang, Yuan-Shan ;Jian-Miao Xu ;Ren-Chao Zheng ;Yu-Guo Zheng ;Yin-Chu Shen pp.1932-1937

High-level secretory expression of human procarboxypeptidase B by fed-batch cultivation of Pichia pastoris and its partial characterization Kim, Mi-Jin ;Sang-Hyuk Kim ;Jae Hyung Lee ;Jin-Ho Seo ;Jong-Hwan Lee ;Jong-Hyun Kim ;Yeon-Hee Kim ;S pp.1938-1944

Enhanced sialylation of recombinant erythropoietin in CHO cells by human glycosyltransferase expression Jeong, Yeon Tae ;One Choi ;Hye Rim Lim ;Young Dok Son ;Hong Jin Kim ;Jung Hoe Kim pp.1945-1952

Construction of recombinant Lactobacillus casei strains using splicing by overlap extension Jeong, Do-Won ;Jong-Hoon Lee ;Hyong Joo Lee pp.1953-1957

Characterizations of denitrifying polyphosphate-accumulating bacterium Paracoccus sp. Strain YKP-9 Lee, Han Woong ;Yong Keun Park pp.1958-1965

Bioremediation potential of a tropical soil contaminated with a mixture of crude oil and production water Alvarez, Vanessa Marques ;Silvia Cristina Cunha dos Santos ;Renata da Costa Casella ;Ronalt Leite Vi pp.1966-1974

Lactobacillus casei secreting α-MSH induces the therapeutic effect on DSS-induced acute colitis in Balb/c Mice Yoon, Sun-Woo ;Chul-Ho Lee ;Jeong-Yoon Kim ;Jie-Youn Kim ;Moon-Hee Sung ;Haryoung Poo pp.1975-1983

Surfactin blocks NO production in Lipopolysaccharide-activated macrophages by inhibiting NF-κB activation Byeon, Se Eun ;Yong Gyu Lee ;Byung Hun Kim ;Ting Shen ;Sang Yeol Lee ;Hwa Jin Park ;Seung-Chun Park pp.1984-1989

Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells Choi, Seok-Keun ;Young-Sam Park ;Dong-Kug Choi ;Hyo-Ihl Chang pp.1990-1996

Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 cells Jin, Cheng-Yun ;Gi-Young Kim ;Yung Hyun Choi pp.1997-203

참고문헌 (39건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Mesalazine inhibits activation of transcription factor NF-KB in inflamed mucosa of patients with ulcerative colitis 네이버 미소장
2 Interleukin 10 gene transfer prevents experimental colitis in rats. 네이버 미소장
3 Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes. 네이버 미소장
4 Blumberg, R. S., (1999) Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr. Opin, Immunol 미소장
5 Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria. 네이버 미소장
6 The anticytokine neuropeptide alpha-melanocyte-stimulating hormone in synovial fluid of patients with rheumatic diseases: comparisons with other anticytokine molecules. 네이버 미소장
7 alpha-Melanocyte stimulating hormone in the modulation of host reactions. 네이버 미소장
8 Anti-Inflammatory Effects of α-Melanocyte-Stimulating Hormone in Celiac Intestinal Mucosa 네이버 미소장
9 Regulation and cloning of the gene encoding amylase activity of the ruminal bacterium Streptococcus bovis. 네이버 미소장
10 Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment. 네이버 미소장
11 Neutrophil studies in psoriatics: in vivo migration, phagocytosis and bacterial killing. 네이버 미소장
12 Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides. 네이버 미소장
13 Gantz, I., (1993) Molecular cloning of a novel melanocortin receptor. J. Biol, Chem 미소장
14 Cortistatin, an Antiinflammatory Peptide with Therapeutic Action in Inflammatory Bowel Disease 네이버 미소장
15 Hogaboam, C. M., (1997) Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. J. Clin, Invest 미소장
16 NF-kappaB at the crossroads of life and death. 네이버 미소장
17 Neutralization of tumour necrosis factor (TNF) but not of IL‐1 reduces inflammation in chronic dextran sulphate sodium‐induced colitis in mice 네이버 미소장
18 Krieglstein, C. F., (2002) Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis. J. Clin, Invest 미소장
19 Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice. 네이버 미소장
20 Lipton, J. M., (1999) Mechanisms of anti-inflammatory action of alpha-MSH peptides: In vivo and in vitro evidence. Ann. N.Y, Acad. Sci 미소장
21 The role of alpha-MSH as a modulator of cutaneous inflammation. 네이버 미소장
22 Crucial role of the melanocortin receptor MC1R in experimental colitis. 네이버 미소장
23 Probiotic Lactobacillus‐induced improvement in murine chronic inflammatory bowel disease is associated with the down‐regulation of pro‐inflammatory cytokines in lamina propria mononuclear cells 네이버 미소장
24 Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. 네이버 미소장
25 Narita, J., (2006) Display of alphaamylase on the surface of Lactobacillus casei cells by use of the PgsA anchor protein, and production of lactic acid from starch. Appl. Environ, Microbiol 미소장
26 A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. 네이버 미소장
27 The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat. 네이버 미소장
28 Papadakis, K. A., (2000) Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu, Rev. Med 미소장
29 Podolsky, D. K., (1991) Inflammatory bowel disease. N. Engl, J. Med 미소장
30 alpha-MSH modulates local and circulating tumor necrosis factor-alpha in experimental brain inflammation. 네이버 미소장
31 alpha-MSH modulates experimental inflammatory bowel disease. 네이버 미소장
32 Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin‐10‐deficient mice 네이버 미소장
33 Lactobacilli as live vaccine delivery vectors: progress and prospects 네이버 미소장
34 Probiotics in inflamatory bowel disease. 네이버 미소장
35 Adenosine kinase inhibitor GP515 improves experimental colitis in mice. 네이버 미소장
36 Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10 네이버 미소장
37 Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. 네이버 미소장
38 Impact of Dextran Sulfate Sodium Load on the Severity of Inflammation in Experimental Colitis 네이버 미소장
39 Vowinkel, T., (2004) Apolipoprotein A-IV inhibits experimental colitis. J. Clin, Invest 미소장

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기