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Background: Toll-like receptors (TLRs) play a fundamental

role in innate immunity through their capacity to recognize

pathogen-associated molecular patterns. Also, TLRs that are

expressed in T cells are reported to function as co-stimulatory

receptors. However, the functional capacity of TLRs

on CD4 T and CD8 T cells has not been directly compared.

Here we compared CD4 and CD8 T cell responses to TLR2

ligand plus TCR-mediated stimulation. Methods: TLR2 expression

was analyzed on T cell subsets under na?e and alloantigen-

primed conditions. We analyzed the effects of

TLR2 co-stimulation on proliferation and survival of T cell

subsets in vitro when stimulated with soluble anti-CD3 in the

presence or absence of synthetic ligand Pam3CSK4. Results:

TLR2 expression on CD8 T cells was induced following activation;

this expression was much higher than on CD4 T cells.

Thus, the molecule was constitutively expressed on Listeriaspecific

memory CD8 T cells. Based on these expression levels,

proliferation and survival were markedly elevated in CD8

T cells in response to the TLR2 co-stimulation by Pam3CSK4

compared with those in CD4 T cells. Conclusion: Our data

show that TLR2 co-stimulation is more responsible for proliferation

and survival of CD8 T cells than for that of CD4 T

cells.

권호기사

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기사명 저자명 페이지 원문 목차
Post-transcriptional regulation of NK cell activation Tae-Don Kim ;Ju Yeong Park ;Inpyo Choi pp.115-121

Regulation of tumor immune surveillance and tumor immune subversion by TGF-β Hae-Young Park ;Lalage M Wakefield ;Mizuko Mamura pp.122-126

Expression and function of TLR2 on CD4 versus CD8 T cells Sun-Mi Lee ;Young-Don Joo ;Su-Kil Seo pp.127-132

Further characterization of activin A-induced IgA response in murine B lymphocytes Hwa-Joung Lee ;Pyeung-Hyeun Kim pp.133-137

Characterization of a novel gene in the extended MHC region of mouse, NG29/Cd320, a homolog of the human CD320 Hyo Jin Park ;Ji-Yeon Kim ;Kyung In Jung ;Tae Jin Kim pp.138-146

참고문헌 (19건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Toll-like receptors. 네이버 미소장
2 Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol 1;135-145, 2001 미소장
3 TLR2 Is Expressed on Activated T Cells as a Costimulatory Receptor 네이버 미소장
4 Toll-like receptor ligands directly promote activated CD4+ T cell survival. 네이버 미소장
5 The Adaptor Molecule MyD88 Activates PI-3 Kinase Signaling in CD4 + T Cells and Enables CpG Oligodeoxynucleotide-Mediated Costimulation 네이버 미소장
6 Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S, Saito T:Cutting edge: TLR2 directly triggers Th1 effector functions.J Immunol 178;6715-6719, 2007 미소장
7 Cottalorda A, Verschelde C, Marçais A, Tomkowiak M,Musette P, Uematsu S, Akira S, Marvel J, Bonnefoy-Berard N: TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation 36;1684-1693,2006 미소장
8 A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. 네이버 미소장
9 MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. 네이버 미소장
10 Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. 네이버 미소장
11 Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP,Pearson TC, Ledbetter JA, Aruffo A, Mittler RS: 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186;47-55, 1997 미소장
12 Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells 네이버 미소장
13 CD8 T cell responses to infectious pathogens. 네이버 미소장
14 Immune therapy for cancer. 네이버 미소장
15 Rapid development of T cell memory. 네이버 미소장
16 Tolerogenic dendritic cells. 네이버 미소장
17 TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. 네이버 미소장
18 Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS 네이버 미소장
19 Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. 네이버 미소장

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