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An activity-guided fractionation method was used to

isolate anticancer components from Nuruk (Rhizopus oryzae

KSD-815:KSD-815). Dried powder of KSD-815 was extracted

with 80% methanol and partitioned successively using nhexane,

ethyl acetate, n-butanol, and water. The n-hexane

and n-butanol fractions showed a strong antimigratory

effect on human cancer cells. Both of these fractions were

subjected to separation and purification procedures using

silica gel, octadecyl silica gel, and Sephadex LH-20 column

chromatographies to afford four purified compounds.

These were identified as ergosterol peroxide (1), stigmast-

5-en-3β,7β-diol (2), ergosta-7,22-dien-3β,5α,6β,9α-tetraol

(3), and daucosterol (4), respectively, by spectroscopic

methods such as nuclear magnetic resonance spectrometry,

mass spectrometry, and infrared spectroscopy, and comparison

with those in the literature. Compounds 1-4 were isolated

from KSD-815 for the first time. Compounds 1 and 4 inhibited

the migration of MDA-MB-231 cells at concentrations

lower than 20 μM.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Distribution patterns of the members of phylum Acidobacteria in global soil smaples Lee, Sang-Hoon ;Jae-Chang Cho pp.1281-1287

Operon required for fruiting body development in Myxococcus xanthus Kim, Dohee ;Jinwoo Chung ;Hyesook Hyun ;Chayul Lee ;Kyoung Lee ;Kyungyun Cho pp.1288-1294

Molecualr cloning and expression of a novel protease-resistant GH-36 α-galactosidase from Rhizopus sp. F78 ACCC 30795 Yanan, Cao ;Yaru Wang ;Hiying Luo ;Pengjun Shi ;Kun Meng ;Zhigang Zhou ;Zhifang Zhang ;Bin Yao pp.1295-1300

Elucidation of multifaceted evolutionary processes of microorganisms by comparative genome-based analysis Nguyen, Thuy Vu An ;Soon Ho Hong ;Sang Yup Lee pp.1301-1305

Structural investigation and homology modeling studies of native and truncated forms of α-amylases from Sclerotinia sclerotiorum Ben Abdelmalek, Imen ;Maria Camino Urdaci ;Mamdouh Ben Ali ;Muriel Denayrolles ;Stephane Chaignepain pp.1306-1318

In vitro antioxidant activity of 5-HMF isolated from marine red alga Laurencia undulata in free radical mediated oxidative systems Li, Yong-Xin ;Yong Li ;Zhong-Ji Qian ;Moon-Moo Kim ;Se-Kwon Kim pp.1319-1327

Sterols isolated from Nuruk (Rhizopus oryzae KSD-815) inhibit the migration of cancer cells Lee, Dae-Young ;Sang-Jin Lee ;Ho-Young Kwak ;Lakoon-Jung ;Jieun Heo ;Sungyoul Hong ;Gye-Won Kim ;Nam pp.1328-1332

Identification of carotenoids from green alga Haematococcus pluvialis by HPLC and Lc-MS (APCI) and their antioxidant properties Ranga, Rao ;A. R. Sarada ;V. Baskaran ;G. A. Ravishankar pp.1333-1341

Production, purification, and characterization of taxol and 10-DABⅢ from a new endophytic fungus Gliocladium sp. isolated from the Indian yew tree, Taxus baccata Sreekanth, D ;A. Syed ;S. Sarkar ;D. Sarkar ;B. Santhakumari ;A. Ahmad ;M. I. Khan pp.1342-1347

2'-hydroxylation of genistein enhanced antioxidant and antiproliferative activities in MCF-7 human breast cancer cells Choi, Jung Nam ;Dockyu Kim ;Hyung Kyoon Choi ;Kyung Mi Yoo ;Jiyoung Kim ;Choong Hwan Lee pp.1348-1354

Astaxanthin inhibits H₂O₂-mediated apoptotic cell death in mouse neural progenitor cells via modulation of P38 and MEK signaling pathways Kim, Jeong-Hwan ;Woobong Choi ;Jong-Hwan Lee ;Sung-Jong Jeon ;Yung-Hyun Choi ;Byung-Woo Kim ;Hyo-Ihl pp.1355-1363

Antimicrobial activity of the cell organelles, lysosomes, isolated from egg white Yoon, Jihee ;Jae-Min Park ;Ki-Ju Kim ;Yang-Hoon Kim ;Jiho Min pp.1364-1368

Continuous production of succinic acid using an external membrane cell recycle system Kim, Moon Il ;Nag Jong Kim ;Longan Shang ;Yong Keun Chang ;Sang Yup Lee ;Ho Nam Chang pp.1369-1373

Optimization of capsular polysaccharide production by Streptococcus pneumoniae type 3 Jin, Sheng-De ;Young-Min Kim ;Hee-Kyoung Kang ;Seung-Jin Jung ;Doman Kim pp.1374-1378

Kinetic study of organic acid formations and growth of Anaerobiospirillum succiniciproducens during continuous cultures Lee, Pyung Cheon ;Sang Yup Lee ;Ho Nam Chang pp.1379-1384

Statistical optimization for improved production of cyclosporin A in solid-state fermentation Survase, Shrikant A ;Uday S. Annapure ;Rekha S. Singhal pp.1385-1392

Purification and characterization of phocaecin PI80 :an anti-listerial bacteriocin produced by Streptococcus phocae PI80 isolated from the gut of Peneaus indicus (Indian white shrimp) Satish Kumar, Ramraj ;Venkatesan Arul pp.1393-1400

Effect of recombinant Lactobacillus expressing canine GM-CSF on immune function in dogs Chung, Jin Young ;Eui Jae Sung ;Chun Gyu Cho ;Kyoung Won Seo ;Jong-Soo Lee ;Dong Ha Bhang ;Hee Woo L pp.1401-1407

Influence of growth conditions on plasmid DNA production Silva, Filomena ;Luis Passarinha ;Fani Sousa ;Joao A. Queiroz ;Fernanda C. Domingues pp.1408-1414

Occurrence of thermophilic Campylobacter spp. contamination on vegetable farms in Malaysia Chai, L. C ;F. M. Ghazali ;F. A. Bakar ;H. Y. Lee ;L. R. A. Suhaimi ;S. A. Talib ;Y. Nakaguchi ;M. N pp.1415-1420

Bioprocess of triphenylmethane dyes decolorization by Pleurotus ostreatus BP under solid-state cultivation Yan, Keliang ;Hongxun Wang ;Xiaoyu Zhang ;Hongbo Yu pp.1421-1430

Isolation and characterization of a plant growth-promoting rhizobacterium, Serratia sp. SY5 Koo, So-Yeon ;Kyung-Suk Cho pp.1431-1438

Isolation of an isocarbophos-degrading strain of Arthrobacter sp. scl-2 and identification of the degradation pathway Li, Rong ;Xinqiang Guo ;Kai Chen ;Jianchun Zhu ;Shunpeng Li ;Jiandong Jiang pp.1439-1446

Two novel duck antibacterial peptides, avian β-defensins 9 and 10, with antimicrobial activity Ma, Deying ;Wenyan Liao ;Ruiqin Wang ;Zongxi Han ;Shengwang Liu pp.1447-1455

Temperature-dependency urease activity in Vibrio parahaemolyticus is related to transcriptional activator UreR Park, Kwon-Sam ;Soo-Jae Lee ;Yong-Hyun Chung ;Tetsuya Iida ;Takeshi Honda pp.1456-1463

Development of TaqMan probe-based real-time PCR method for erm(A) erm(B), and erm(C), rapid detection of macrolide-lincosamide-streptogramin B resistance genes, from clinical isolates Jung, Jae-Hyuk ;Eun-Jeong Yoon ;Eung-Chil Choi ;Sung-Sook Choi pp.1464-1469

Direct multiplex reverse transcription-nested PCR detection of influenza viruses without RNA purification Song, Man Ki ;Jun Chang ;Yeongjin Hong ;Sunghoi Hong ;Suhng Wook Kim pp.1470-1474

Detection of virulence-associated genes in clinical isolates of Bacillus anthracis by multiplex PCR and DNA probes Kumar, Sanjay ;Urmil Tuteja pp.1475-1481

Anti-proliferative effect of polysaccharides from Salicornia herbacea on induction of G2/M arrest and apoptosis in human colon cancer cells Ryu, Deok-Seon ;Seon-Hee Kim ;Dong-Seok Lee pp.1482-1489

Neuronal differentiation of PC12 cells cultured on growth factor-loaded nanoparticles coated on PLGA microspheres Park, Keun-Hong ;Hyemin Kim ;Kun Na pp.1490-1495

참고문헌 (17건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 The phagokinetic tracks of 3T3 cells 네이버 미소장
2 Chang, J. H. 1989. History of Korean spirits. Korean J. Dietary Culture 4: 271-274. 미소장
3 Kim, C. J. 1969. Microbiological and enzymological studies on Takju brewing. J. Korean Agric. Chem. Soc. 10: 69-100. 미소장
4 Kim, G. W., W. C. Shin, Y. H. Oh, and Y. M. Won. 2001. Novel Rhizopus sp. KSD-815 producing glucoamylase with high activity. Republic of Korean Patent 10-0781053-0000. 미소장
5 Structures of Five Hydroxylated Sterols from the Seeds of Trichosanthes Kirilowii MAXIM. 네이버 미소장
6 Mechanisms of metastasis. 네이버 미소장
7 Lee, D. Y., M. C. Song, J. S. Yoo, S. H. Kim, I. S. Chung, D. K. Kim, and N. I. Baek. 2006. Development of biologically active compounds from edible plant sources. XVII. Isolation of sterols from the fruits of Cornus kousa Burg. J. Korean Agric. Chem. Soc. 49: 82-85. 미소장
8 Phenolic Phytochemicals Derived from Red Pine (Pinus densiflora) Inhibit the Invasion and Migration of SK‐Hep‐1 Human Hepatocellular Carcinoma Cells 네이버 미소장
9 Lyu, H. N., J. S. Yoo, M. C. Song, D. Y. Lee, D. H. Kim, Y. D. Rho, I. H. Kim, and N. I. Baek. 2007. Development of biologically active compounds from edible plant sources. XVIII. Isolation of derivatives of ergosterol from the fruit body of Phellinus linteus. J. Korean Agric. Chem. Soc. 50: 57-62. 미소장
10 Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays 네이버 미소장
11 Ergosterol, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol peroxide and chitin in ergoty barley, rye and other grasses 네이버 미소장
12 Biotechnology in Balance 네이버 미소장
13 α-Chaconine-reduced Metastasis Involves a PI3K/Akt Signaling Pathway with Downregulation of NF-κB in Human Lung Adenocarcinoma A549 cells 네이버 미소장
14 Spiricheva, O. V., O. V. Sen'ko, D. V. Veremeenko, and E. N. Efremenko. 2007. Lactic acid production by immobilized cells of the fungus Rhizopus oryzae with simultaneous product extraction. Theor. Found. Chem. Eng. 41: 150-153. 미소장
15 Yu, T. S., S. H. Yeo, and H. S. Kim. 2004. A new species of Hyphomycetes, Aspergillus coreanus sp. nov., isolated from traditional Korean nuruk. J. Microbiol. Biotechnol. 14: 182-187. 미소장
16 Sterols from the fungus Lactarium volemus 네이버 미소장
17 Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity 소장

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