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한국학술지인용색인(NRF)
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To investigate whether caffeic acid phenethyl ester (CAPE) could affect cancer cell viabilities and gene expression, human colorectal HCT116 cells were incubated with CAPE. CAPE decreased cancer cell viabilities and induced apoptosis in a dose-dependent manner. To analyse differently expressed genes by CAPE, we performed oligo DNA microarray analysis. We found that 266 genes were up-regulated more than twofold, whereas 143 genes were down-regulated more than twofold by 24 hr of treatment with 20 μM CAPE. Among the up-regulated genes, we selected 3 genes (NSAID activated gene-1 [NAG-1], cyclin-dependent kinase inhibitor 1A [CDKN1A, p21] and growth arrest and DNA-damage-inducible alpha [GADD45A]) and performed reverse-transcription PCR to confirm microarray data. In addition, we found that CAPE increased NAG-1 gene and NAG-1 protein expression in a dose-dependent manner. And, several other phytochemicals (resveratrol, genistein, daidzein and capsaicin) also could induce NAG-1 expression in human colorectal HCT116 cells. However, CAPE was the highest inducer of NAG-1, even in low concentrations. Overall, these results imply that cancer cell death by CAPE is closely related with over-expression of NAG-1.
권호기사
참고문헌 (25건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities.  |
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| 2 | Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53 |
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| 3 | Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 Over Expression in Transgenic Mice Suppresses Intestinal Neoplasia |
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| 4 | The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells |
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| 5 | Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction. |
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| 6 | Corn, P. G. and W. S. El-Deiry. 2007. Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage. Cancer Biol. Ther. 6, 1858-1866. | 미소장 |
| 7 | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds |
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| 8 | The Branching Gene RAMOSUS1 Mediates Interactions among Two Novel Signals and Auxin in Pea |
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| 9 | Gastroenterologists Named to Scientific Advisory Committee for Liver Toxicology Study |
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| 10 | Cancer |
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| 11 | Jin, U. H., K. H. Song, M. Motomura, I. Suzuki, Y. H. Gu, Y. J. Kang, T. C. Moon, and C. H. Kim. 2008. Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells. Mol. Cell Biochem. 310, 43-48. | 미소장 |
| 12 | Jung, W. K., I. Choi, D. Y. Lee, S. S. Yea, Y. H. Choi, M. M. Kim, S. G. Park, S. K. Seo, S. W. Lee, C. M. Lee, Y. M. Park, and I. W. Choi. 2008. Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways. Int. J. Biochem. Cell Biol. 40, 2572-2582. | 미소장 |
| 13 | Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo |
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| 14 | Lampe, J. W. and J. L. Chang. 2007. Interindividual differences in phytochemical metabolism and disposition. Semin. Cancer Biol. 17, 347-353. | 미소장 |
| 15 | Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B |
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| 16 | ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors. |
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| 17 | Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. |
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| 18 | Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. |
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| 19 | Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray |
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| 20 | Sun, S. Y., N. Hail Jr, and R. Lotan. 2004. Apoptosis as a novel target for cancer chemoprevention. J. Natl. Cancer Inst. 96, 662-672. | 미소장 |
| 21 | Surh, Y. J. 2003. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3, 768-780. | 미소장 |
| 22 | Using DNA microarray analyses to elucidate the effects of genistein in androgen‐responsive prostate cancer cells: Identification of novel targets |
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| 23 | Gastroenterology Subspecialty Consult |
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| 24 | Wilson, L. C., S. J. Baek, A. Call, and T. E. Eling. 2003. Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. Int. J. Cancer 105, 747-753. | 미소장 |
| 25 | Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling. |
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