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Whole plants of Vitex rotundifolia were extracted for 2 days with methylene chloride (CH2Cl2) followed by extraction of the residue for an additional 2 days. The same procedure was also applied using methanol (MeOH). The two crude extracts were combined and partitioned between CH2Cl2 and H2O. The organic layer was further partitioned between n-hexane and 85% aq. MeOH, and the aqueous layer was also further fractionated with n-BuOH and H2O, successively. From the 85% aq. MeOH fraction, one compound was isolated through the repeated HPLC. According to the results of physicochemical data including NMR and MS, the chemical structure of the compound was determined as artemetin (1). The antiproliferative effects of the crude extracts, fractions, and compound against HT1080, AGS, MCF-7 and HT-29 human cancer cells were compared with the control by using MTT assay. In the comparative analysis, the 85% aq. MeOH fraction exhibited the strongest antiproliferative effects on human cancer cell lines in a dose-dependent manner (p<0.05). In addition, exposure of compound 1 isolated from 85% aq. MeOH fraction led to strong antiproliferative effect in HT1080 cancer cell lines. These results suggest that the extracts and compound isolated from V. rotundifolia may be used as potential chemopreventive and chemotherapeutic agents.

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기사명 저자명 페이지 원문 목차
한천분해세균 Cellvibrio mixtus SC-22의 분리 및 효소적 특성 차정아 ;김유진 ;서영범 ;윤민호 pp.157-162

Isolation, identification, and characterization of Pichia guilliermondii K123-1 and Candida fermentati SI, producing isoflavone β-glycosidase to hydrolyze isoflavone glycoside efficiently, from the Korean traditional soybean past Won-Chan Kim ;Jai-Hyun So ;Sang-In Kim ;Jae-Ho Shin ;Kyung-Sik Song ;Choon-Bal Yu ;Yung-Hee Kho ;In- pp.163-169

Immunoblotting reactivity of vitellogenin antibodies against native vitellogenins and a vitellogenin protein fragment produced in E. coli Hyung-Seok Ryu ;In-Young Jang ;Woo-Yeon Kim pp.170-173

19종 시판 탄화초액의 항산화활성의 평가 및 비교 김성필 ;남석현 pp.174-179

순비기 나무(Vitex rotundifolia) 추출·분획물 및 화합물의 인체 암세포 증식억제 효과 김유아 ;이정임 ;김해진 ;공창숙 ;남택정 ;서영완 pp.180-186

참당귀(Angelica gigas)에서 분리한 pyranocurmarin 성분의 ACAT 저해활성 및 참당귀 부위별 pyranocurmarin 성분의 함량 분석 김금숙 ;박춘근 ;정태숙 ;차선우 ;백남인 ;송경식 pp.187-194

오이 흰가루병 방제 효과가 우수한 계면활성제 유주현 ;최경자 ;임희경 ;김흥태 pp.195-199

냉동저장기간에 따른 멜론(Cucumis melo L.)의 생리활성 변화 조준구 ;윤선주 ;이은탁 ;김태완 ;권대준 pp.200-204

한국 재래식 간장 제조를 위한 메주의 크기와 제조 방법에 따른 품질특성 이종구 ;권광일 ;정명근 ;권오준 ;최지영 ;임무혁 pp.205-211

Suppression effect of Curcuma longa rhizome-derived components against nitric oxide synthase Hoi-Seon Lee pp.212-215

한국 자생식물 추출물의 항산화 및 Aldo-keto Reductase Family 1 B10 효소 억제 효과 판철호 ;이주영 ;송대근 ;김종환 ;안수용 ;배덕성 ;김영훈 ;이재권 pp.216-220

지치뿌리로부터 분리한 Acetylshikonin의 LDL 산화 저해활성과 FPTase 저해활성 김금숙 ;정태숙 ;권병목 ;김영옥 ;차선우 ;송경식 ;백남인 pp.221-225

참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Ahmad VU, Khan MA, Baqai FT, and Tareen RB (1995) Santoflavone, a 5-deoxyflavonoid from Achillea santolina. Phytochemistry 38, 1305-1307. 미소장
2 Doll R (1992) The lessons of life. Cancer Res 52, 2024S-2029S. 미소장
3 Hansen MB, Nielsen SE, and Berg K (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119, 203-210. 미소장
4 Hernández MM, Heraso C, Villarreal ML, Vargas-Arispuro I, and Aranda E (1999) Biological activities of crude plant extracts from Vitex trifolia L. (Verbenaceae). J Ethnopharmacol 67, 37-44. 미소장
5 Hirobe C, Qiao ZS, Takeya K, and Itokawa H (1997) Cytotoxic flavonoids from Vitex agnus-castus. Phytochemistry 46, 521-524. 미소장
6 Iinuma M, Matsuura S, and Kusuda K (1980) 13C-Nuclear magnetic resonance (NMR) spectral studies on polysubstituted flavonoids. I. 13C-NMR spectra of flavones. Chem Pharm Bull 28, 708-716. 미소장
7 Jo KJ, Yoon MY, Lee MR, Cha MR, and Park HR (2007) The anticancer effect of extracts from Vitex rotundifolia on human colon carcinoma cell lines. J Korean Soc Appl Biol Chem 50, 228-232. 미소장
8 Antiproliferative Activity of Flavonoids on Several Cancer Cell Lines 네이버 미소장
9 Ko WG, Kang TH, Lee SJ, Kim NY, Kim YC, Sohn DH, and Lee BH (2000) Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem Toxicol 38, 861-865. 미소장
10 Kong CS, Yeom YR, Lee JI, Kim YA, Lee JS, and Seo Y (2008) Inhibition effects of extracts and its solvent fractions isolated from Limonium tetragonum on growth of human cancer cells. Korean J Biotechnol Bioeng 23, 177-182. 미소장
11 Lee YN (2002) In Flora of Korea, p 241, Kyo-Hak Publishing Co. Ltd., Seoul, Korea. 미소장
12 Ng TB, Liu F, and Wang HX (2004) The antioxidant effects of aqueous and organic extracts of Panax quinquefolium, Panax notoginseng, Codonopsis pilosula, Pseudostellaria heterophylla and Glehnia littoralis. J Ethnopharmacol 93, 285-288. 미소장
13 Ono M, Yanaka T, Yamamoto M, Ito Y, and Nohara T (2002) New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. J Nat Prod 65, 537-541. 미소장
14 Park EJ and Pezzuto JM (2002) Botanicals in cancer chemoprevention. Cancer Metast Rev 21, 231-255. 미소장
15 Park JG, Frucht H, LaRocca RV, Bliss DP, Kurita Y, Chen TR, Henslee JG, Trepel JB, Jensen RT, Johnson BE, Bang YJ, Kim JP, and Gazdar AF (1990) Characterization of cell lines established from human gastric carcinoma. Cancer Res 50, 2773-2780. 미소장
16 Rahman AU, Ahmed D, Choudhary MI, Turkoz S, and Sener B (1988) Chemical constituents of Buxus sempervirens. Planta Med 54, 173-174. 미소장
17 Sadhu SK, Okuyama E, Fujimoto H, Ishibashi M, and Yesilada E (2006) Prostaglandin inhibitory and antioxidant components of Cistus laurifolius, a Turkish medicinal plant. J Ethnopharmacol 108, 371-378. 미소장
18 Seo Y, Lee HJ, Kim YA, and Park KE (2004) Antioxidative effect of glasswort (Saliconia herbacea) extract from Daebudo. Proceeding of Current Biotechnology and Bioengineering 10, 1-7. 미소장
19 Shin TY, Kim SH, Lim JP, Suh ES, Jeong HJ, Kim BD, Park EJ, Hwang WJ, Rye DG, Baek SH, An NH, and Kim HM (2000) Effect of Vitex rotundifolia on immediate-type allergic reaction. J Ethnopharmacol 72, 443-450. 미소장
20 Shur YJ (2004) Cancer chemopreventive effects of dietrary phytochemicals. J Korean Assoc Cancer Preven 9, 68-83. 미소장
21 Stan SD, Kar S, Stoner GD, and Singh SV (2008) Bioactive food components and cancer risk reduction. J Cell Biochem 104, 339-356. 미소장
22 Wang HY, Cai B, Cui CB, Zhang DY, and Yang BF (2005) Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway. Yao Xue Xue Bao 40, 27-31. 미소장
23 Yoshioka T, Inokuchi T, Fujioka S, and Kimura Y (2004) Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. Z Naturforsch 59, 509-514. 미소장
24 You KM, Son KH, Chang HW, Kang SS, and Kim HP (1998) Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. Planta Med 64, 546-550. 미소장

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