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Purpose :
We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.
Materials and Methods :
Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.
Results :
Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p<0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.
Conclusion :
In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients’ care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 19 | Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. ![]() |
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| 20 | Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. ![]() |
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| 21 | T1 Breast Cancer: Identification of Patients at Low Risk of Axillary Lymph Node Metastases ![]() |
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| 22 | Frequency and predictors of axillary lymph node metastases in invasive breast cancer ![]() |
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| 23 | A Randomized Trial Comparing Axillary Dissection to No Axillary Dissection in Older Patients With T1N0 Breast Cancer: Results After 5 Years of Follow-up ![]() |
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| 24 | Result of Sentinel Lymph Node Biopsy Using Radioisotope in Clinically Lymph Node Negative Breast Cancer | 소장 |
| 25 | Predicting axillary lymph node metastases in patients with T 1infiltrating ductal carcinoma of the breast ![]() |
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