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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Purpose

With their prolonged survival and malnutrition, cancer patients, and especially gastrointestinal (GI) tract cancer patients, can develop Wernicke’s encephalopathy (WE). The aim of this study is to remind physicians of the importance of WE and prompt management in patients with GI tract cancer.

Materials and Methods

This study is a retrospective review of 2 cases of WE in advanced gastric cancer (AGC) patients, and we review the literature for cases of GI tract cancer related to WE.

Results

A 48-year-old female with AGC presented dizziness and diplopia for 5 days and a 20 kg weight loss. Neurologic exam showed nystagmus and gaze disturbance. Her symptoms improved after daily parenteral injection of thiamine 100 mg for 17 days. A 58-year-old female with AGC presented with sudden disorientation, confusion and 15 kg weight loss. Neurologic exam showed gaze limitation and mild ataxia. Despite daily parenteral injection of thiamine 100 mg for 4 days, she died 5 days after the onset of neurologic symptoms. Combining the cases noted in the literature review with our 2 cases, the 7 gastric cancer cases and 2 colorectal cancer cases related to WE showed similar clinical characteristics; 1) a history of long-period malnutrition and weight loss, 2) relatively typical neurologic signs and symptoms and 3) specific magnetic resonance image findings. Except for 2 patients who had irreversible neurologic symptoms, the other 7 patients were improved with prompt thiamine treatment.

Conclusion

It is important to consider WE in GI tract cancer patients with acute neurologic symptoms and who are in a state of malnutrition. Thiamine should be given as soon as possible when WE is suspected.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Geriatric oncology :an overview of progresses and challenges Martine Extermann pp.61-68

Clinicopathologic characteristics, surgical treatment and outcomes for splenic flexure colon cancer Chan Wook Kim ;Ui Sup Shin ;Chang Sik Yu ;Jin Cheon Kim pp.69-76

Wernicke's encephalopathy in advanced gastric cancer Eun Suk Jung ;Obin Kwon ;Soo Hyun Lee ;Ki Byung Lee ;Joo Hoon Kim ;Sang Hyun Yoon ;Gun Min Kim ;Hei- pp.77-81

Time-course transcriptional profiling of human amniotic fluid-derived stem cells using microarray Yong Wook Kim ;Hyun-Jung Kim ;Su-Mi Bae ;Young Jae Kim ;Jong-Chul Shin ;Heung-Jae Chun ;Jong-Won Rhi pp.82-94

Role of loss of O⁶-methylguanine DNA methyltransferase (MGMT) expression in non-small cell lung carcinomas (NSCLCs) :with reference to the relationship with p53 overexpression Na-Hye Myong pp.95-100

Predictive value of the ERCC1 expression for treatment response and survival in advanced gastric cancer patients receiving cisplatin-based first-line chemotherapy Jina Yun ;Kyoung-Mee Kim ;Seung Tae Kim ;Jung-Hoon Kim ;Jung A Kim ;Jee Hyun Kong ;Soo Hyeon Lee ;Yo pp.101-106

(The)Keratin-14 expression in actinic keratosis and squamous cell carcinoma :is this a prognostic factor for tumor progression? Kwang Hyun Choi ;Gyong Moon Kim ;Si Yong Kim pp.107-114

(A)Case of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma Jung-Hye Choi ;Young-Ha Oh ;Ile-Kyu Park pp.115-117

(A)Case of 5-fluorouracil induced encephalopathy Kyung A Kwon ;Hyuk-Chan Kwon ;Min Chan Kim ;Sung-Hyun Kim ;Sung Yong Oh ;Suee Lee ;Hyo-Jin Kim pp.118-120

Follicular dendritic cell sarcoma :a case report and review of the literature Bo Sik Choi ;Jin Ho Baek ;Young Min Shin ;Jong Hyung Kim ;Hyung Wook Kim ;Soon Jung Lee ;Hee Jeong C pp.121-124

참고문헌 (20건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser. 1971;7:1-206. 미소장
2 Thiamin Deficiency and Korsakoff's Syndrome 네이버 미소장
3 Wernicke's encephalopathy in non-alcoholics 네이버 미소장
4 Wernicke Encephalopathy in Nonalcoholic Patients 네이버 미소장
5 Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management 네이버 미소장
6 Thiamine-responsive acute neurological disorders in nonalcoholic patients. 네이버 미소장
7 Reversible impairment of cerebral DNA synthesis in thiamine deficiency. 네이버 미소장
8 Wernicke's encephalopathy: a more common disease than realised. A neuropathological study of 51 cases. 네이버 미소장
9 Wernicke C. Lehrbuch der gehirnkrankheiten für aerzte und studirende. Kassel Theodor Fischer. 1881;2:229-42. 미소장
10 Ropper A, Brown R. Adams and Victor’s Principles of Neurology. 8th ed. New York: McGraw-Hill; 2005. 미소장
11 Fluorouracil-induced neurotoxicity. 네이버 미소장
12 Acute Encephalopathy Attributed to 5-FU 네이버 미소장
13 Intermediate dose 5-fluorouracil-induced encephalopathy. 네이버 미소장
14 Korea National Statistical Office, National database of cancer (1999-2002): Annual report of statistisc of death causes. Seoul: Korea National Statistical Office; 2005. 미소장
15 Severe acute metabolic acidosis and Wernicke's encephalopathy following chemotherapy with 5-fluorouracil and cisplatin: case report and review of the literature. 네이버 미소장
16 Diffusion-weighted imaging in Wernicke encephalopathy associated with stomach cancer: case report and review of the literature. 네이버 미소장
17 Successful treatment of Wernicke encephalopathy in terminally ill cancer patients: Report of 3 cases and review of the literature 네이버 미소장
18 Wernicke’s Encephalopathy following Gastrectomy in Patients with Gastric Cancer 소장
19 Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging 네이버 미소장
20 Magnetic resonance imaging in a case of Wernicke's encephalopathy. 네이버 미소장

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