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This study investigated the potential effects of amitraz on the pre- and postnatal

development, behavior, and reproductive performance of offspring of parent rats given amitraz during

pre-mating, gestation, and lactation. The test chemical was administered via the drinking water

containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day

mating period and to females from 2 weeks before mating, throughout mating, gestation and lactation

up to weaning. Based on fluid consumption, the male rats received an average of 0, 5.7 ?1.33,

13.2 ?2.08, and 35.8 ?3.42 mg/kg/day amitraz, and the female rats received an average of 0,

8.7 ?4.42, 20.1 ?9.60, and 47.6 ?22.38 mg/kg/day amitraz, respectively. At 360 ppm, an increase in

the incidence of abnormal clinical signs, a suppression in the body weight gain, a decrease in the

food consumption and litter size, an increase in the post-implantation loss, and a decrease in the seminal

vesicle weight were observed in the parent animals. In addition, a suppression in the body weight

gain, a decrease in the grip strength, a delay in the negative geotaxis, an increase in the pre- and

post-implantation loss, and a decrease in the number of live embryos were observed in the offspring.

At 120 ppm, suppressed body weight gain and reduced food consumption were observed in the parent

rats. Suppressed body weight gain and decreased grip strength were also observed in the offspring.

There were no signs of either reproductive or developmental toxicity at 40 ppm. Under these

experimental conditions, the no-observed-adverse-effect level of amitraz for parent rats and their

offspring was estimated to be 40 ppm in rats.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Norepinephrine induces MAIL mRNA expression in primary cultured hepatocytes through IL-1β released from non-parenchymal cells Hyeon-Cheol Kim ;Bae Dong Jung pp.79-84

산삼배양액 급여에 따른 육계의 생산성 및 질병 저항성 효과 설재원 ;박재홍 ;채준석 ;강형섭 ;류경선 ;강춘성 ;박상열 pp.85-91

랫드에서 amitraz의 출생 전후 발생 시험 김성환 ;임정현 ;박나형 ;문창종 ;박수현 ;강성수 ;배춘식 ;김성호 ;신동호 ; pp.93-103

Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과 허진주 ;김종수 ;김준형 ;남상윤 ;윤영원 ;정재황 ;이범준 pp.105-111

Comparative study of Clostridium perfringens, Salmonella spp. and E. coli focused on characteristics of E. coli O157 isolated from pigs of HACCP- and non-HACCP-accredited swine farms in Korea Hyun Ok Keum ;Hye Kwon Kim ;Se Mi Rho ;Hyoung Joon Moon ;Seong Jun Park ;Bong Kyun Park pp.113-116

국내 경북지역 소에서 분리된 브루셀라 분리주의 생물학적 특성 김정화 ;임정주 ;김동혁 ;이진주 ;김대근 ;전무형 ;김상훈 ;장홍희 ;이후장 ; pp.117-124

돼지 희석정액의 세균오염도 및 유효 항생제 선발 김하영 ;변재원 ;신동호 ;김형순 ;윤하정 ;박최규 ;이오수 ;정병열 pp.125-131

Rabies immune status in the stray and companion dogs in Korea Dong-Kun Yang ;Soon-Seek Yoon ;Kyoung-Ki Lee ;Jae-Won Byun ;You-Chan Bae ;Yoon-I Oh ;Jae-Young Song pp.133-137

제주흑우 송아지에서 소 합포체성 폐렴의 발생 :증례보고 김현태 ;정지열 ;조숙희 ;이경갑 ;김재훈 pp.139-143

Phenidone, a dual inhibitor of cyclooxygenase and lipoxygenase, inhibits carbon tetrachloride-induced acute liver injury in rats Hyuop Choi ;Donghwan Joeng ;Bae-Dong Jung ;Taekyun Shin ;Myung-Bok Wie pp.145-149

엘크의 구포자충 감염사례 :증례보고 윤순식 ;배유찬 ;변재원 ;이경현 ;장환 ;송재영 ;위성환 pp.151-154

CO₂ 레이저와 scalpel을 이용한 위 절개 시 개에서의 창상 치유 평가 이재연 ;황유선 ;김한결 ;최현석 ;정성목 ;조성환 ;박창식 ;김명철 pp.155-160

참고문헌 (35건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 김종춘, 이상준, 배진숙, 박종일, 김용범, 정문구. Sprague-Dawley 랫드를 이용한 발생독성시험의 기초자료연구. 한국독성학회지 2001, 17, 83-90. 미소장
2 Background Data for Fertility and Early Embryonic Development Study in Sprague-Dawley Rats 소장
3 Amitraz poisoning: clinical and laboratory findings. 네이버 미소장
4 Assessment of reproductive and fertility effects of amitraz pesticide in male mice 네이버 미소장
5 Postnatal development of locomotion in the laboratory rat 네이버 미소장
6 Nature 네이버 미소장
7 Minimal behavioral effects from developmental cerebellar stunting in young rats induced by postnatal treatment with α-difluoromethylornithine 네이버 미소장
8 Cardiovascular and respiratory effects of the acaricide amitraz. 네이버 미소장
9 Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats 네이버 미소장
10 Fisher RA, Bennett JH, Yates F. Statistical Methods, Experimental Design, and Scientific Inference. pp. 1- 323, Oxford University Press, Oxford, 1990. 미소장
11 Effects of amitraz on motor function. 네이버 미소장
12 Suppression of the luteinizing hormone surge by chlordimeform in ovariectomized, steroid-primed female rats. 네이버 미소장
13 Chlordimeform-induced alterations in endocrine regulation within the male rat reproductive system 네이버 미소장
14 Hayes WJ. Handbook of Pesticide Toxicology. Vol. 1. Academic Press, San Diego, 1991. 미소장
15 Androgen modulation of the messenger ribonucleic acid of retinoic acid receptors in the prostate, seminal vesicles, and kidney in the rat. 네이버 미소장
16 An unusual poisoning with the unusual pesticide amitraz. 네이버 미소장
17 Evaluation of Developmental Toxicity of Amitraz in Sprague-Dawley Rats 네이버 미소장
18 Use of Ranks in One-Criterion Variance Analysis 네이버 미소장
19 Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats 네이버 미소장
20 Amitraz Poisoning in Humans 네이버 미소장
21 Reproductive and Developmental Toxicity of Amitraz in Sprague-Dawley Rats 네이버 미소장
22 A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. 네이버 미소장
23 Investigations of amitraz neurotoxicity in rats: IV. Assessment of toxicity syndrome using a functional observational battery 네이버 미소장
24 Yohimbine attenuates the delayed lethality induced in mice by amitraz, a formamidine pesticide 네이버 미소장
25 Effect of flutamide on the physiological status of epididymis and epididymal sperms. 네이버 미소장
26 Palanza P, Parmigiani S, vom Saal FS. Effects of prenatal exposure to low doses of diethylstilbestrol, o,p'DDT, and methoxychlor on postnatal growth and neurobehavioral development in male and female mice. Horm Behav 2001, 40, 252-265. 미소장
27 Developmental and behavioral effects of prenatal amitraz exposure in rats 네이버 미소장
28 Developmental and behavioral effects of postnatal amitraz exposure in rats 네이버 미소장
29 EFFECT OF PETHIDINE ON SPERMATOGENESIS IN ALBINO RATS 네이버 미소장
30 Poisoning with Amitraz 네이버 미소장
31 A Method for Judging all Contrasts in the Analysis of Variance 네이버 미소장
32 Influence of the Formamidine Pesticide Amitraz and Its Metabolites on Porcine Myometrial Contractility - Involvement of α 2-Adrenoceptors and Ca 2+ Channels 네이버 미소장
33 Acute amitraz intoxication in human 네이버 미소장
34 Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction, teratogenesis or carcinogenesis 네이버 미소장
35 Yim GKW, Holsapple MP, Pfister WR, Hollingworth RM. Prostaglandin synthesis inhibited by formamidine pesticides. Life Sci 1978, 23, 2509-2515. 미소장

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