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The differentiation of leukemia cells into mature cells is a major target of the human leukemia therapy.

As differentiated leukemia cells lose their proliferative and tumor-forming abilities, differentiation inducers may

be useful for the treatment of leukemia. In this study, the experiments were designed to determine whether diallyl disulfide

(DADS) regulates expressions of tumor suppressor protein PTEN (phosphatase and tension homologue) in HL-

60 cells. DADS causes upregulation of PTEN in a time- and dose-dependent manner, which was correlated with

decrease of phospho-Akt level. These results suggest that DADS induces upregulation of PTEN in human leukemia

cells. These results suggest that DADS may be a useful anticancer agent for management of human leukemia.

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기사명 저자명 페이지 원문 목차
소비자의 식품안전 인지도와 안전행동 평가 박지연 ;최은희 ;최정화 ;심상국 ;박형수 ;박기환 ;문혜경 ;류경 pp.1-11

식용유지의 가열시 와송 추출물이 산화안정성에 미치는 영향 이수정 ;신정혜 ;서종권 ;성낙주 pp.12-18

미래 집단 급식 식중독 발생 양상 예측 조서희 ;김초일 ;하상도 pp.19-26

서울 강북지역 유통 농산물 중 농약잔류실태조사 박성규 ;하광태 ;김성단 ;김시정 ;이윤정 ;이경아 ;장정임 ;정삼식 ;송부용 ; pp.27-37

Diallyl disulfide (DADS) induces upregulation of PTEN in human leukemia cells Weon Kuu Chung ;Byoung Kil Lee ;Young-Rae Lee ;Jinny Park ;Hyoung Chul Kwon pp.38-45

N-methyl-N-nitro-N'-nitrosoguanidine의 변이원성에 대한 결명자 물 추출물의 항돌연변이 효과 안병용 pp.46-49

국내 즉석섭취 신선채소류 중 Listeria monocytogenes위해수준 평가 오덕환 ;Tian Ding ;하상도 ;박경진 pp.50-55

과실쥬스 및 음료에서 파튤린 오염실태 조사 엄준호 ;변정아 ;박유경 ;서은채 ;이은미 ;김미라 ;선남규 ;김창수 ;정우영 ; pp.56-62

미생물 위해평가를 위한 포장돈육 가공환경조건에 대한 확률통계학적 분석 오덕환 ;S. M. E. Rahman ;김재명 ;박경진 pp.63-68

랫드에서 밤의 과육 및 내피가 지방대사 및 항혈전능에 미치는 영향 김소정 ;김미환 ;김진 ;김형진 ;김수현 ;이성호 ;박영석 ;박병권 ;김병수 ;김 pp.69-77

차가버섯, 상황버섯 및 영지버섯 복합추출물 복용이 인체의 혈중 조혈모세포와 면역세포에 미치는 영향 배형석 ;강성근 ;신일섭 ;우상규 ;김윤정 ;김미애 ;라정찬 pp.78-85

빙과류의 미생물학적 위해요소에 대한 품질 평가 김태웅 ;최재호 ;김재명 ;Tian Ding ;S.M.E. Rahman ;박경진 ;오덕환 pp.86-93

작두콩 첨가 된장과 일반 된장의 생리활성 특성 비교 이학태 ;김종호 ;이상선 pp.94-101

재래 된장과 시판 된장의 미생물 오염 및 바이오제닉 아민 함량 분석 이학태 ;김종호 ;이상선 pp.102-109

참고문헌 (55건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Aggarwal BB, Shishodia S, Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71(10):1397-421. 미소장
2 Diet and Cancer: Facts and Controversies 네이버 미소장
3 Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, Biserni R, Cipriani F, Cocco P, Giacosa A, et al., A casecontrol study of gastric cancer and diet in Italy. Int J. Cancer.1989, 44(4):611-6. 미소장
4 Kwon KB, Yoo SJ, Ryu DG, Yang JY, Rho HW, Kim JS, Park JW, Kim HR, and Park BH, Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem. Pharmacol. 2002, 63(1):41-7. 미소장
5 Park EK, Kwon KB, Park KI, Park BH, and Jhee EC, Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells. Exp. Mol. Med. 2002, 34(3):250-7. 미소장
6 Eng C, Murday V, Seal S, Mohammed S, Hodgson SV, Chaudary MA, Fentiman IS, Ponder BA, Eeles RA, Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J. Med. Genet. 1994, 31(6):458-61. 미소장
7 Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R, Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 1997, 16(1):64-7. 미소장
8 Ali IU, Schriml LM, Dean M, Mutational spectra of PTEN/ MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J. Natl. Cancer Inst. 1999, 91(22):1922-32. 미소장
9 Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford- Thomas D, Leone G, Eng C, Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Hum. Mol. Genet. 2001, 10(3):251-8. 미소장
10 Vivanco I, Sawyers CL, The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer. 2002, 2(7):489-501. 미소장
11 Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C, PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum. Mol. Genet. 1999, 8(2):185-93. 미소장
12 Phosphoinositide kinases. 네이버 미소장
13 Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C, Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels,but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.Am. J. Pathol. 2001, 158(6):2097-106. 미소장
14 The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression. 네이버 미소장
15 PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. 네이버 미소장
16 PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. 네이버 미소장
17 Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford- Thomas D, Leone G, Eng C, Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.. Hum. Mol. Genet. 2001, 10(3):251-8. 미소장
18 Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. 네이버 미소장
19 Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. 네이버 미소장
20 Lee YR, Yu HN, Noh EM, Kim JS, Song EK, Han MK, Kim BS, Lee SH, Park J., Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells. Int. J. Hematol. 2007, 85(3):231-7.. 미소장
21 Lachyankar MB, Sultana N, Schonhoff CM, Mitra P, Poluha W, Lambert S, Quesenberry PJ, Litofsky NS, Recht LD, Nabi R, Miller SJ, Ohta S, Neel BG, Ross AH, A role for nuclear PTEN in neuronal differentiation. J. Neurosci. 2000, 20(4):1404-13. 미소장
22 Sugatani T, Alvarez U, Hruska KA. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J. Biol. Chem. 2003, 278(7):5001-8. 미소장
23 Induction of Differentiation of the Human Promyelocytic Leukemia Cell Line (HL-60) by Retinoic Acid 네이버 미소장
24 Collins SJ, Bodner A, Ting R, Gallo RC, Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murine leukemia cells. Proc. Natl. Acad. Sci. U. S. A. 1978, 75(5):2458-62. 미소장
25 Terminal differentiation of the human promyelocytic leukemia cell line, HL-60, in the absence of cell proliferation. 네이버 미소장
26 Fischkoff SA, Pollak A, Gleich GJ, Testa JR, Misawa S, Reber TJ, Eosinophilic differentiation of the human promyelocytic leukemia cell line, HL-60. J. Exp. Med.1984, 160(1):179-96. 미소장
27 Induction of Terminal Differentiation in Human Promyelocytic Leukemia Cells by Tumor-Promoting Agents 네이버 미소장
28 Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60. 네이버 미소장
29 Mangelsdorf DJ, Koeffler HP, Donaldson CA, Pike JW, Haussler MR, 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL- 60):receptor-mediated maturation to macrophage-like cells. J. Cell Biol. 1984, 98(2):391-8. 미소장
30 All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. 네이버 미소장
31 Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS, TNFalpha upregulates PTEN via .NF-kappaB signaling pathways in human leukemic cells. Exp. Mol Med. 2007, 39(1):121-7. 미소장
32 Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells. 네이버 미소장
33 Recombinant human interferon sensitizes resistant myeloid leukemic cells to induction of terminal differentiation 네이버 미소장
34 Synergistic effect of IL-4 and TNF-alpha in the induction of monocytic differentiation of a mouse myeloid leukaemic cell line (WEHI-3B JCS). 네이버 미소장
35 Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells. 네이버 미소장
36 Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. 네이버 미소장
37 Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper ME, Chai Z, Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J. Biol. Chem. 2007, 282(16):11722-31. 미소장
38 Shen YH, Zhang L, Gan Y, Wang X, Wang J, LeMaire SA, Coselli JS, Wang XL, Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells. J. Biol. Chem. 2006, 281(12):7727-36. 미소장
39 Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation. 네이버 미소장
40 Gastroenterology in the Netherlands 네이버 미소장
41 Knowles LM, Milner JA, Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells. J. Nutr. 2003, 133(9):2901-6. 미소장
42 Zhang YW, Wen J, Xiao JB, Talbot SG, Li GC, Xu M, Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells. Arch. Pharm. Res. 2006, 29(12):1125-31. 미소장
43 Wen J, Zhang Y, Chen X, Shen L, Li GC, Xu M, Enhancement of diallyl disulfide-induced apoptosis by inhibitors of MAPKs in human HepG2 hepatoma cells. Biochem. Pharmacol. 2004, 68(2):323-31. 미소장
44 Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H, Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumorselective death ligand TRAIL. Nat. Med. 2001, 7(6):680-6. 미소장
45 Apoptosis: Corralling the Corpses 네이버 미소장
46 PPAR-gamma modulates allergic inflammation through up-regulation of PTEN. 네이버 미소장
47 Teresi RE, Shaiu CW, Chen CS, Chatterjee VK, Waite KA, Eng C, Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. Int. J. Cancer. 2006, 118(10):2390-8. 미소장
48 Zhang W, Wu N, Li Z, Wang L, Jin J, Zha XL, PPAR gamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL- 7404. Cancer Biol. Ther. 2006, 5(8):1008-14. 미소장
49 Zhang W, Wu N, Li Z, Wang L, Jin J, Zha XL, PPAR gamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL- 7404. Cancer Biol. Ther. 2006, 5(8):1008-14. 미소장
50 Ling H, Zhang LY, Su Q, Song Y, Luo ZY, Zhou XT, Zeng X, He J, Tan H, Yuan JP, Erk is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cellline MGC803. Cell Mol. Biol. Lett. 2006, 11(3):408-23. 미소장
51 Dirsch VM, Keiss HP, Vollmar AM, Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule Eselectin in human endothelial cells. Eur. J. Nutr. 2004, 43(1):55-9. 미소장
52 DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages. 네이버 미소장
53 Diallyl disulfide suppresses growth of HL-60 cell through increasing histone acetylation and p21WAF1 expression in vivo and in vitro. 네이버 미소장
54 Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS) 네이버 미소장
55 Lee JH, Kim KA, Kwon KB, Kim EK, Lee YR, Song MY , Koo JH, Ka SO, Park JW, Park BH, Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells. Int. J. Mol. Med. 2007, 20(1):59-64. 미소장

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