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초록보기

The Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat cancers. However, limited information exists on the underlying

anticancer effects of the major component of I. obliquus in vivo. We hypothesize that the pure compounds (3β-hydroxy-lanosta-8,24-dien-21-al,

inotodiol and lanosterol, respectively) separated from I. obliquus would inhibit tumor growth in Balbc/c mice bearing Sarcoma-180 cells (S-180)

in vivo and growth of human carcinoma cells in vitro. To test this hypothesis, the growth inhibition of each subfraction isolated from I. obliquus

on human carcinoma cell lines (lung carcinoma A-549 cells, stomach adenocarcinoma AGS cells, breast adenocarcinoma MCF-7 cells, and cervical

adenocarcinoma HeLa cells) was tested in vitro. Then, after S-180 implantation, the mice were fed a normal chow supplemented with 0, 0.1 or

0.2 mg of subfraction 1, 2 or 3 per mouse per day. All of the subfractions isolated from I. obliquus showed significant cytotoxic activity against

the selected cancer cell lines in vitro. Subfraction 1 was more active than subfraction 2 and subfraction 3 against the A549, AGS and MCF-7

cancer cell lines in vitro. In in vivo results, subfraction 1 isolated from I. obliquus at concentrations of 0.1 and 0.2 mg/mouse per day significantly

decreased tumor volume by 23.96% and 33.71%, respectively, as compared with the control. Subfractions 2 and 3 also significantly inhibited tumor

growth in mice bearing S-180 as compared with the control mouse tumor. Subfraction 1 isolated from I. obliquus showed greater inhibition of

tumor growth than subfractions 2 and 3, which agrees well with the in vitro results. The results suggest that I. obliquus and its compounds in

these subfractions isolated from I. obliquus could be used as natural anticancer ingredients in the food and/or pharmaceutical industry.

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기사명 저자명 페이지 원문 목차
Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing sarcoma-180 cells Mi Ja Chung ;Cha-Kwon Chung ;Yoonhwa Jeong ;Seung-Shi Ham pp.177-182

Protective effect of enzymatic hydrolysates from highbush blueberry (Vaccinium corymbosum L.) against hydrogen peroxide-induced oxidative damage in Chinese hamster lung fibroblast cell line Mahinda Senevirathne ;Soo-Hyun Kim ;You-Jin Jeon pp.183-190

Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet Minji Kim ;Yangha Kim pp.191-195

Neuroprotective effects of consuming bovine colostrum after focal brain ischemia/reperfusion injury in rat model Han Sung Choi ;Young Gwan Ko ;Jong Seok Lee ;Oh Young Kwon ;Sun-Kyu Kim ;Chul Cheong ;Ki-Hyo Jang ;S pp.196-202

(The)Effect of oligonol intake on cortisol and related cytokines in healthy young men Jeong-Beom Lee ;Young-Oh Shin ;Young-Ki Min ;Hun-Mo Yang pp.203-207

High participation in the Posyandu nutrition program improved children nutritional status Faisal Anwar ;Ali Khomsan ;Dadang Sukandar ;Hadi Riyadi ;Eddy S. Mudjajanto pp.208-214

Nutritional and antioxidant status by skin types among female adults Hyun Sook Bae ;Sung Im Choi ;Hong Seok Ahn pp.215-221

Assessing exclusive breastfeeding practices, dietary intakes and body mass index (BMI) of nursing mothers in Ekiti state of Nigeria Oluwole Steve Ijarotimi pp.222-228

Dietary source of vitamin B_12_ intake and vitamin B_12_ status in female elderly Koreans aged 85 and older living in rural area Chung Shil Kwak ;Mee Sook Lee ;Hae Jeung Lee ;Jin Yong Whang ;Sang Chul Park pp.229-234

Dietary factors related to body weight in adult Vietnamese in the rural area of Haiphong, Vietnam :the Korean genome and epidemiology study (KoGES) Sun Hye Kim ;Ji-Yun Hwang ;Mi Kyung Kim ;Hye Won Chung ;Tran Thi Phuc Nguyet ;Wha Young Kim pp.235-242

Noodle consumption patterns of American consumers :NHANES 2001-2002 Chin Eun Chung ;Kyung Won Lee ;Mi Sook Cho pp.243-251

참고문헌 (20건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. 네이버 미소장
2 Roland JF, Chmielewicz ZF, Weiner BA, Gross AM, Boening OP, Luck JV, Bardos TJ, Reilly HC, Sugiura K, Stock CC, Lucas EH, Byerrum RU, Scevena JA. Calvacin: A new antitumor agent. Science 1960;132:1897. 미소장
3 Studies on Antitumor Substances Produced by Basidiomycetes 네이버 미소장
4 Fungi in khanty folk medicine 네이버 미소장
5 Antimutagenic and Cytotoxic Effects of Ethanol Extract from the Inonotus obliquus 소장
6 Antioxidant and Genotoxic Inhibition Activity of Ethanol Extract from the Inonotus obliquus 소장
7 3β-Hydroxy-lanosta-8,24-dien-21-al, a New Triterpene from Inontus obliquus 네이버 미소장
8 Inhibition of HIV-1 Protease by Water-Soluble Lignin-Like Substance from an Edible Mushroom, Fuscoporia obliqua 네이버 미소장
9 Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. 네이버 미소장
10 Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. 네이버 미소장
11 Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. 네이버 미소장
12 ZINC-mediated gene expression offers protection against H2O2-induced cytotoxicity. 네이버 미소장
13 Antimutagenic and Antitumor Effects of Adenophora triphylla Extracts 소장
14 Inhibitory effects of preventive and curative orally administered spinach glycoglycerolipid fraction on the tumor growth of sarcoma and colon in mouse graft models 네이버 미소장
15 Masou salmon ( Oncorhynchus masou) ethanol extract decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase expression in diet-induced obese mice 네이버 미소장
16 Kahlos K, Hiltunen R. Identification of some lanostane type triterpenes from Inonotus obliquus. Acta Pharmaceutica Fennica 1983;92:220-2. 미소장
17 Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae) 네이버 미소장
18 Kahlos T, Zhuangas L, Hitunen R. Antitumor activity of some compounds and fractions from an n-hexene extract of Inonotus obliquus. Acta Pharmaceutica Fennica 1987;96:33-40. 미소장
19 Inotodiol, a Lanostane Triterpenoid, from Inonotus obliquus Inhibits Cell Proliferation through Caspase-3-dependent Apoptosis 네이버 미소장
20 Potential anticancer properties of the water extract of Inontus obliquus by induction of apoptosis in melanoma B16-F10 cells 네이버 미소장

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