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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Purpose: B cell-activating factor (BAFF) is a tumor-necrosis factor

(TNF) superfamily member best known for its role in the survival and

maturation of B cells. BAFF activity is observed in na?e cells as well

as in effector/memory T cells. We aimed to explore whether BAFF

in sputum is expressed at elevated levels in asthmatic airways and

associated with eosinophilic inflammation, pulmonary function, and

bronchial hyperresponsiveness in children.

Methods: One hundred and fifty-four asthmatic children and 98

healthy children were enrolled in the study. Sputum supernatants were

collected and sputum BAFF and eosinophil cationic protein (ECP)

levels were measured. We performed pulmonary function tests and

methacholine challenge tests, while measuring total eosinophil count,

total serum IgE, and serum ECP in all subjects.

Results: Asthmatic children had significantly higher levels of BAFF in

induced sputum [26.50 (10.50-100.27) pg/mL] compared to healthy

children [18.32 (7.68-44.63) pg/mL; P=0.011]. Sputum BAFF positively

correlated with sputum eosinophils (γ=0.406, P<0.001) and sputum

ECP (γ=0.789, P<0.001). Significant negative correlations were

found between sputum BAFF and FEV1 (γ=-0.291, P<0.001) or postbronchodilator

FEV1 (γ=-0.334, P<0.001), whereas nonsignificant

correlations were found between sputum BAFF and bronchial

hyperresponsiveness, serum eosinophil count, and serum ECP.

Conclusion: These findings suggest that BAFF may play a role in

childhood asthma, and BAFF levels in sputum could be a supportive

marker that represents airway inflammation, especially eosinophilic

inflammation.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Multimodal neuroimaging in presurgical evaluation of childhood epilepsy Da Eun Jung ;Joon-Soo Lee pp.779-785

Disease-specific pluripotent stem cells Hoon-Chul Kang pp.786-789

(The)Effect of sucrose on infants during a painful procedure Kyoung Hwa Joung ;Soo Chul Cho pp.790-794

Increased B cell-activating factor (BAFF) level in the sputum of children with asthma Hye Mi Jee ;Bong Seok Choi ;Kyung Won Kim ;Myung Hyun Sohn ;Man Yong Han ;Kyu-Earn Kim pp.795-800

Needle aspiration as therapeutic management for suppurative cervical lymphadenitis in children Mee Young Baek ;Kyung Hee Park ;Ju Hee We ;Su Eun Park pp.801-804

Successful treatment by exchange transfusion of a young infant with sodium nitroprusside poisoning Jong Geun Baek ;Hoar Lim Jeong ;Ji Sook Park ;Ji Hyun Seo ;Eun Sil Park ;Jae Young Lim ;Chan Hoo Par pp.805-808

(A)Case of bartter syndrome type Ⅰ with atypical presentations Eun Hye Lee ;Ju Sun Heo ;Hyun Kyung Lee ;Kyung Hee Han ;Hee Gyung Kang ;Il Soo Ha ;Yong Choi ;Hae Il pp.809-813

참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 T cell activation, from atopy to asthma: more a paradox than a paradigm 네이버 미소장
2 Lemanske RF Jr., Busse WW. 6. Asthma. J Allergy Clin Immunol 2003;111(2 Suppl):502S -19S. 미소장
3 Mak TW, Yeh WC. Signaling for survival and apoptosis in the immune system. Arthritis Res 2002;4 Suppl 3:S243-52. 미소장
4 BAFF production by antigen‐presenting cells provides T cell co‐stimulation 네이버 미소장
5 Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, Casali P, et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 2002;3:822-9. 미소장
6 Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol 2002;2:465-75. 미소장
7 Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. 네이버 미소장
8 An Essential Role for BAFF in the Normal Development of B Cells through a BCMA-Independent Pathway 네이버 미소장
9 T cell costimulation by the TNF ligand BAFF. 네이버 미소장
10 B cell-activating factor is a novel diagnosis parameter for asthma. 네이버 미소장
11 Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis 네이버 미소장
12 TACI:Fc scavenging B cell activating factor (BAFF)alleviates ovalbumin-induced bronchial asthma in mice 소장
13 The global burden of asthma: executive summary of the GINA Dissemination Committee Report 네이버 미소장
14 Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309-29. 미소장
15 Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma. 네이버 미소장
16 Normal predicted values of pulmonary function test in Korean school-aged children 네이버 미소장
17 Airway inflammation in asthma with incomplete reversibility of airflow obstruction 네이버 미소장
18 Safety and application of induced sputum analysis in childhood asthma 네이버 미소장
19 Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps 네이버 미소장
20 BAFF augments certain Th1-associated inflammatory responses. 네이버 미소장
21 Mechanisms of eosinophil-associated inflammation 네이버 미소장

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