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한국학술지인용색인(NRF)
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Background: The presence of porcine endogenous retrovirus (PERV) has been
considered as one of the main hurdles to transplant pig’s organs or tissues to human
beings. There has been no report that PERV infection is associated with human
diseases. Because pigs have their own characteristics of PERV according to pig strain,
it is necessary to analyze the infectivity of PERV from SNU miniature pig to human
cells for future utilization as a transplantation donor.
Materials and Methods: Human cell lines were infected with culture supernatant
from porcine cell line or immunomodulator-stimulated peripheral blood
mononuclear cells (PBMC) of SNU miniature pigs. They were also co-cultured with
PBMC or islet cells of SNU miniature pigs. The presence of PERV genes and general
pig marker gene in cells was determined by nested PCR with primer set for PERV pol
and pig mitochondrial cytochrome oxidase II (COII), respectively.
Results: Infection test with the culture supernatant from PBMC of SNU miniature
pigs showed that PERV pol but not COII was detected only in a few cases, but there
was no uniform infection pattern in scope of stimulators and cell types. PERV pol
was not demonstrated in co-cultures of human cell line with PBMC or islet cells from
SNU miniature pigs after 80 days of co-cultures.
Conclusions: In vitro infectivity test suggests that PERV from SNU miniature pig
might not replicate productively in human cell lines although it could infect human
cells and integrate into chromosome.권호기사
참고문헌 (23건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Xenotransplantation  |
미소장 |
| 2 | Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997;3: 282-6. | 미소장 |
| 3 | Porcine Endogenous Retroviruses Inhibit Human Immune Cell Function: Risk for Xenotransplantation? |
미소장 |
| 4 | Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. |
미소장 |
| 5 | No evidence of porcine endogenous retrovirus in patients with type 1 diabetes after long‐term porcine islet xenotransplantation |
미소장 |
| 6 | Differences in release and determination of subtype of porcine endogenous retroviruses produced by stimulated normal pig blood cells. |
미소장 |
| 7 | Parameters for successful pig islet isolation as determined using 68 specific-pathogen-free miniature pigs. |
미소장 |
| 8 | TRANSMISSION OF PORCINE ENDOGENOUS RETROVIRUSES IN SEVERE COMBINED IMMUNODEFICIENT MICE XENOTRANSPLANTED WITH FETAL PORCINE PANCREATIC CELLS1 |
미소장 |
| 9 | C-type virus particles in pig kidney cell lines. |
미소장 |
| 10 | Two sets of human-tropic pig retrovirus. |
미소장 |
| 11 | Host range and interference studies of three classes of pig endogenous retrovirus. |
미소장 |
| 12 | Transmission of pig endogenous retrovirus to primary human cells |
미소장 |
| 13 | Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV) |
미소장 |
| 14 | Productive Infection of Human Primary Cells and Cell Lines with Porcine Endogenous Retroviruses |
미소장 |
| 15 | Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. |
미소장 |
| 16 | Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells. |
미소장 |
| 17 | Comparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells. |
미소장 |
| 18 | Molecularly cloned porcine endogenous retroviruses replicate on human cells |
미소장 |
| 19 | Restriction of retroviral replication by APOBEC3G/F and TRIM5alpha. |
미소장 |
| 20 | LACK OF CROSS-SPECIES TRANSMISSION OF PORCINE ENDOGENOUS RETROVIRUS INFECTION TO NONHUMAN PRIMATE RECIPIENTS OF PORCINE CELLS, TISSUES, OR ORGANS1 |
미소장 |
| 21 | Characterization of Clones of Human Cell Line Infected with Porcine Endogenous Retrovirus (PERV) from Porcine Cell Line, PK-15 | 소장 |
| 22 | Long-term effects on HEK-293 cell line after co-culture with porcine endogenous retrovirus |
미소장 |
| 23 | A RAPID METHOD FOR DETECTION OF THE COPY NUMBER OF PORCINE ENDOGENOUS RETROVIRUS IN SWINE |
미소장 |
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