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결과 내 검색
동의어 포함
1. Objectives
4 herbal formulas (Yanggyeoksanhwa-tang, Yeoldahanso-tang, Cheongsimyeonja-tang and Taeeumjowi-tang) were applied to investigate the anti-inflammatory activities. In many studies, plant-derived anti-inflammatory efficacies have been investigate for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory activities of 4 herbal formulas on LPS-stimulated RAW 264.7 cells.
2. Methods
The productions of nitric oxide (NO), prostaglandin (PG)E2, interleukin(IL)-6 and tumor necrosis factor (TNF)-α were examined in the presence of the 4 herbal formulas in RAW 264.7 cells. The cells were incubated with LPS 1 μg/mL and 4 herbal formulas for 18 hrs. The anti-inflammatory activity of 4 herbal formulas were investigate by carrageenin-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenin- induced paw edema in rats.
3. Results
Yanggyeoksanhwa-tang and Cheongsimyeonja-tang showed inhibitory effect on PGE2 production in LPS-stimulated RAW 264.7 cells and a reduction in carrageenin-induced paw edema on rats. Yanggyeoksanhwa-tang showed inhibi- tory effect on IL-6 in LPS-stimulated RAW 264.7 cells. 4 herbal formulas not affect on NO and TNF-α inhibition in LPS-stimulated RAW 264.7 cells.
4. Conclusions
These results suggested that Yanggyeoksanhwa-tang and Cheongsimyeonja-tang have anti-inflammatory activity.| 기사명 | 저자명 | 페이지 | 원문 | 목차 |
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| 15 | Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation. ![]() |
미소장 |
| 16 | Methanol extracts of Stewartia koreana inhibit cyclooxygenase-2(COX-2) and inducible nitric oxide synthase (iNOS) gene expression by blocking NF-κB transactivation in LPS-activated RAW 264.7 cells | 소장 |
| 17 | Geranylgeranylacetone Induces Cyclooxygenase-2 Expression in Cultured Rat Gastric Epithelial Cells Through NF-κB ![]() |
미소장 |
| 18 | Nitric oxide synthases: Roles, tolls, and controls ![]() |
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| 19 | The Nitric Oxide Theory of Aging Revisited ![]() |
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| 21 | Pharmacological and Biochemical Demonstration of the Role of Cyclooxygenase 2 in Inflammation and Pain ![]() |
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| 22 | Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract ![]() |
미소장 |
| 23 | Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. ![]() |
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| 24 | The local anti-inflammatory action of dexamethasone in the rat carrageenin oedema model is reversed by an antiserum to lipocortin 1. ![]() |
미소장 |
| 25 | Anti-inflammatory and analgesic effects of magnolol. ![]() |
미소장 |
| 26 | Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. ![]() |
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| 27 | Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics. 7th ed. New York: MacMillan. 1985:674. | 미소장 |
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