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Chunghyul-dan acts as an anti-inflammatory agent in endothelial cells by regulating gene expression / Woo Sang Jung ; Jingu Cho ; Kyungmin In ; Jongmin Kim ; Ki Ho Cho ; Jung Mi Park ; Sang Kwan Moon ; Kyung Wook Kim ; Seong Uk Park ; Jaeho Pyee ; Sang Gyu Park ; Yoonhwa Jeong ; Heonyong Park ; Chang Nam Ko 1

[요약] 1

Introduction 1

Materials and methods 2

Results 3

Discussion 6

References 7

초록보기

Chunghyul-dan (CHD) is a combinatorial drug known to exert anti-inflammatory effects in endothelial cells. In this

study, we employed global transcriptional profiling using cDNA microarrays to identify molecular mechanisms

responsible for the anti-inflammatory activity of CHD in endothelial cells. An analysis of the microarray data

revealed that transcript levels of monocyte chemotactic protein-1 (MCP-1), vascular cell-adhesion molecule-1

(VCAM-1) and activated leukocyte cell-adhesion molecule were dramatically altered in CHD-treated endothelial

cells. These changes in gene expression were confirmed by RT-PCR, Western blotting and ELISA. Chronic CHD

treatment also appeared to decrease MCP-1 secretion, probably as a result of decreased MCP-1 expression. In

addition, we determined that chronic CHD treatment inhibited lipopolysaccharide-stimulated adhesion of THP-1

leukocytes to endothelial cells. The inhibitory effect of CHD on LPS-stimulated adhesion resulted from downregulation

of VCAM-1 expression. Transmigration of THP-1 leukocytes through endothelial cells was also inhibited

by chronic CHD treatment. In conclusion, CHD controls a variety of inflammatory activities by regulating MCP-1

and VCAM-1 gene expression.

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기사명 저자명 페이지 원문 목차
Transplantation of human adipose-derived stem cells into the urethra ameliorates stress urinary incontinence and blunts the induction of c-Fos immunoreactivities in brain areas related to micturition in female rats Sung-Eun Kim ,Il-Gyu Ko ,Bo-Kyun Kim ,Yun-Hee Sung ,Mal-Soon Shin ,Sehyung Cho ,Chang-Ju Kim ,Khae-Hawn Kim ,Kyo-Won Lee ,Dong-Hee Kim pp.237-244

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Effects of ATP and ADP on iron uptake in rat heart mitochondria Misun Kim ,Eunsook Song pp.245-252

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Antidepressant-like effect of chlorogenic acid isolated from Artemisia capillaris Thunb. Soo-Hyun Park ,Yun-Beom Sim ,Pyung-Lim Han ,Jin-Koo Lee ,Hong-Won Suh pp.253-259

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Butyrate-induced differentiation of PC12 cells to chromaffin cells involves cell adhesion and induction of extracellular proteins and cell adhesion proteins Jee-In Heo, Soo-Jin Oh, Yoon-Jung Kho, Jeong-hyeon Kim, Hong-Joon Kang, Seong-Hoon Park, Hyun-Seok Kim, Jong-Yeon Shin, Sung-Young Lee, Min-Ju Kim, Bon-Hong Min, Sung Chan Kim, Jae-Bong Park, Jaebong Kim, Jae-Yong Lee pp.261-266

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Effects of a mild heat treatment on mouse testicular gene expression and sperm quality Jun Zhao ,Ying Zhang ,Linlin Hao ,Jia Wang ,Jiabao Zhang ,Songcai Liu ,Bingzhong Ren pp.267-274

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Chunghyul-dan acts as an anti-inflammatory agent in endothelial cells by regulating gene expression Woo Sang Jung ,Jingu Cho ,Kyungmin In ,Jongmin Kim ,Ki Ho Cho ,Jung Mi Park ,Sang Kwan Moon ,Kyung Wook Kim ,Seong Uk Park ,Jaeho Pyee ,Sang Gyu Park ,Yoonhwa Jeong ,Heonyong Park ,Chang Nam Ko pp.275-282

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Inhibitory effect of Ssanghwa-tang on bone loss in ovariectomized rats Ki-Shuk Shim ,Ji-Hye Lee ,Choong Je Ma ,Yoon-Hee Lee ,Sung-Up Choi ,JaeHoon Lee ,Jin Yeul Ma pp.283-289

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Estimation of mortality coefficients and survivorship curves for minke whales(Balaenoptera acutorostrata) in Korean waters Chang Ik Zhang ,Kyung-Jun Song ,Jong-Hun Na pp.291-296

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Seasonal and diel abundance and feeding patterns of Chaoborus flavicans in Sang-Chun reservoir Garam Jeong ,Sangkyu Park pp.297-303

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Comparative genetic diversity of wild and released populations of Pacific abalone Haliotis discus discus in Jeju, Korea, based on cross-species microsatellite markers including two novel loci Hye Suck An ,Seong Wan Hong ,En Mi Kim ,Jeong-Ho Lee ,Jae Koo Noh ,Hyun Chul Kim ,Chul Ji Park ,Byung Hwa Min ,Jeong-In Myeong pp.305-313

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Age structure and growth rates of two Korean salamander species(Hynobius yangi and Hynobius quelpaertensis) from field populations Jung-Hyun Lee ,Mi-Sook Min ,Tae-Ho Kim ,Hae-Jun Baek ,Hang Lee ,Daesik Park pp.315-322

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Early zoeal stages of edible crab Erimacrus isenbeckii(Brandt, 1848) (Crustacea: Decapoda: Brachyura: Cheiragonidae) and a comparison with other cheiragonid zoeae Chu Lee ,Hyun Sook Ko pp.323-331

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Larval development of Scyra acutifrons(Crustacea: Decapoda: Epialtidae) with a key from the northern Pacific Seong Mi Oh ,Hyun Sook Ko pp.333-341

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Ultrastructural studies of vitellogenesis in oocytes and follicle cells during oogenesis in female Protothaca(Notochione) jedoensis(Bivalvia: Veneridae) Hee-Woong Kang ,Ki-Ho Choi ,Je-Cheon Jun ,Ki-Young Lee ,Kwan-Ha Park pp.343-349

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First record of the family Cletopsyllidae(Copepoda: Harpacticoida) from Korean waters, with description of a new species Sung Joon Song ,Won Kim ,Ui Wook Hwang pp.351-360

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참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Ardigo D, Assimes TL, Fortmann SP, Go AS, Hlatky M, Hytopoulos E, Iribarren C, Tsao PS, Tabibiazar TR. 2007. Quertermous; ADVANCE Investigators. Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. Physiol Genomics. 31:402 409. 미소장
2 Chemokines in the pathogenesis of vascular disease. 네이버 미소장
3 Daio-Orengedokudo works as a cell-proliferating compound in endothelial cells. 네이버 미소장
4 From medical herbalism to phytotherapy in dermatology: back to the future 네이버 미소장
5 Flow-mediated endothelial mechanotransduction 네이버 미소장
6 Direct observations in vivo on the role of endothelial selectins and alpha(4) integrin in cytokine-induced leukocyte-endothelium interactions in the mouse aorta. 네이버 미소장
7 Eriksson EE, Xie X, Werr J, Thoren P, Lindbom L. 2001. Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins. FASEB J. 15:1149 1157. 미소장
8 Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptide. 네이버 미소장
9 Inflammation and coronary artery disease. 네이버 미소장
10 Jo H, Sipos K, Go YM, Law R, Rong J, McDonald JM. 1997. Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways. J Biol Chem. 272:1395 1401. 미소장
11 Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer 네이버 미소장
12 Kim YS, Jung EA, Shin JI, Chan JC, Yang HK, Kim NJ, Cho KH, Bae HS, Moon SK, Kim DH. 2002. Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase. Biol Pharm Bull. 25:1442 1445. 미소장
13 Chemokines and chemokine receptors in infectious diseases. 네이버 미소장
14 Masedunskas A, King JA, Tan F, Cochran R, Stevens T, Sviriov D, Ofori-Acquah SF. 2006. Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration. FEBS Lett. 580:2637 2645. 미소장
15 PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways. 네이버 미소장
16 Navab M, Imes SS, Hama SY, Hough GP, Ross LA, Bork RW, Valente AJ, Berliner JA, Drinkwater DC, Laks. 1991. Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J Clin Invest. 88:2039 2046. 미소장
17 Park H, Go YM, St John PL, Maland MC, Lisanti MP, Abrahamson DR, Jo H. 1998. Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase. J Biol Chem. 273:32304 32311. 미소장
18 Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. 네이버 미소장
19 Chunghyul-Dan (Qingxie-Dan) Improves Arterial Stiffness in Patients with Increased baPWV 네이버 미소장
20 Ramos CL, Huo Y, Jung U, Ghosh S, Manka DR, Sarembock IJ, Ley K. 1999. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res. 84:1237 1244. 미소장
21 Schepers A, Eefting D, Bonta PI, Grimbergen JM, de Vries MR, vanWeel V, de vries CJ, Egashira K, van Bockel JH, Quax PH. 2006. Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo. Arterioscler Thromb Vasc Biol. 26:2063 2069. 미소장
22 Sertic J, V XJ, Bozina N, Malencia B, Kes P, Reiner Z. 2007. Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology. Clin Chem Lab Med. 45:1347 1352. 미소장
23 Chemokines and atherosclerosis. 네이버 미소장
24 Shin J, Kim J, Ryu B, Chi S, Park H. 2006. Caveolin-1 is associated with VCAM-1 dependent adhesion of gastric cancer cells to endothelial cells. Cell Physiol Biochem. 17:211 220. 미소장
25 Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW. 1995. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. Circulation. 92:1355 1374. 미소장
26 [Mechanism of protective effects of ouren-gedoku-to and san'ou-syashin-to on the gastric mucosa]. 네이버 미소장
27 Thomas PD, Campbell MJ, Kejariwal A, Mi H, Karlak B, Daverman R, Diemer, Muruganujan A, Narechania A. 2003. PANTHER: a library of protein families and subfamilies indexed by function. Genome Res. 13:2129 2141. 미소장
28 Weiss JM, Nath A, Major EO, Berman JW. 1999. HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. J Immunol. 163:2953 2959. 미소장

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