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Contents

24-ethylcholesta-4,24(28)-dien-3,6-dione from Osmanthus fragrans var. aurantiacus flowers inhibits the growth of human colon cancer cell line, HCT-116 / Do-Gyeong Lee ; Ji-Hae Park ; Ki-Hyun Yoo ; In-Sik Chung ; Youn-Hyung Lee ; Jong-Ki Lee ; Dae-Seok Han ; Sueng-Mock Cho ; Nam-In Baek 1

[요약] 1

Materials and Methods 2

Plant materials. 2

Reagents and Instruments. 2

Extraction of O. fragrans var. aurantiacus flowers and isolation of sterols. 2

β-Sitosterol (1): 3

Fucosterol (2): 3

24-Ethylcholesta-4,24(28)-dien-3,6-dione (3): 3

Daucosterol (4): 3

Cell culture. 3

Cytotoxicity assay. 3

Results and Discussion 4

Acknowledgment. 5

References 5

초록보기

Fucosterol (2), oxygenated fucosterol, 24-ethylcholesta-4,24(28)-dien-3,6-dione (3), β-sitosterol (1), and daucosterol (4) were isolated from ethyl acetate (EtOAc) fraction of Osmanthus fragrans var.aurantiacus flower by repeated silica gel, octadecyl silica gel, and Sephadex LH-20 column chromatography. The sterol structures were determined based on spectroscopic methods including nuclear magnetic resonance, infrared spectroscopy, fast atom bombardment mass spectrometry, and electron ionization mass spectrometry. Fucosterol (2), oxygenated fucosterol, and 24-ethylcholesta-4,24(28)-dien-3,6-dione (3) are representative sterols mainly isolated from marine algae, but rarely found in land plants. This is the first reported isolation of these sterols from O.fragrans var. aurantiacus. Interestingly, the oxygenated fucosterol (3) isolated inhibited the in vitro growth of the HCT-116 human colon cancer cell line with higher cytotoxic effects than doxorubicin, a well-known cytotoxic drug.

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참고문헌 (13건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 New stigmastane sterols from Ajuga salicifolia. 네이버 미소장
2 A cytotoxic butenolide, two new dolabellane diterpenoids, a chroman and a benzoquinol derivative formosan Casearia membranacea. 네이버 미소장
3 Choi YJ (1999), In Cultivation Techniques of Tree, O-Sung Publishing Company, Seoul, Korea. 미소장
4 Application of HS-SPME and GC-MS to characterization of volatile compounds emitted from Osmanthus flowers. 네이버 미소장
5 Ham YM, Kim Kn, Lee WJ, Lee NH, and Hyun CG (2010), "Chemical constituents from Sargassum micracanthum and antioxidant activity",Int J Pharm 6, pp.147-151. 미소장
6 Neuroprotection and free radical scavenging effects of Osmanthus fragrans. 네이버 미소장
7 Immunoregulatory activity by daucosterol, a β-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice 네이버 미소장
8 Lee SH, Lee YS, Jung SH, Kang SS, and Shin KH (2003), "Antioxidant activities of fucosterol from the marine algae Pevetia siliquosa",Arch Pharm Res 26, pp.719-722. 미소장
9 Hepatoprotective and Anti-diabetic Effects of Pelvetia siliquosa, a Marine Algae, in Rats 소장
10 Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. 네이버 미소장
11 Oh YS, Lee IK, and Boo SM (1990), "An annotated account of Korean economic seaweeds for food, medical and industrial uses",Kor J Phycor 5, pp.57-71. 미소장
12 New cytotoxic oxygenated fucosterols from the brown alga Turbinaria conoides. 네이버 미소장
13 Isolation and Identification of Lipids from the Silkworm (Bombyx mori) Droppings 소장

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