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Background: Propofol is used as an induction and maintenance agent for general anesthesia but it can cause adverse

reactions like hyperlipidemia, growth of microorganisms, and pulmonary embolisms. Microemulsion propofol

was developed to avoid these side effects but incidence and severity of pain on injection is higher than with lipid

emulsion propofol. We aimed to compare the effects of sufentanil in analgesic doses for reducing the injection pain

of microemulsion propofol.

Methods: The candidates included eighty patients, 19-60 years old and ASA I-II. They were randomly classified

into four groups and pretreated with normal saline, sufentanil 0.1 μg/kg, 0.2 μg/kg or 0.3 μg/kg before injection of

microemulsion propofol. Five minutes after receiving pretreatment drug, 2 mg/kg of microemulsion propofol was

injected and VAS was recorded.

Results: There were no significant differences in the incidence of injection pain among the groups. Severity of

injection pain was significantly lower in the sufentanil 0.3 μg/kg group than normal saline and sufentanil 0.1 μg/

kg group. Significant differences in blood pressure and heart rate were observed in sufentanil groups only after

endotracheal intubation. One patient each in sufentanil 0.1 μg/kg and 0.3 μg/kg group experienced mild cough, one

from sufentanil 0.3 μg/kg group experienced dizziness and another showed signs of hypoxia. One patient each in

normal saline and sufentanil 0.1 μg/kg group showed clinical symptoms of phlebitis in the injection area.

Conclusions: Pretreatment with sufentanil 0.3 μg/kg reduced the severity of microemulsion propofol injection pain

without increasing arterial blood pressure and heart rate after endotracheal intubation.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
(The)effect of low fresh gas flow rate on sevoflurane consumption Ho-Geol Ryu ,Ji-Hyun Lee ,Kyung-Ku Lee ,Nam-Su Gil ,Chong Soo Kim ,Sung-Eun Sim ,Sang Chul Lee ,Seong-Won Min pp.75-77

(The)effect of priming injection of different doses of remifentanil on injection pain of microemulsion propofol premixed with lidocaine Cheol Won Jeong ,Seong Heon Lee ,Jin Ju ,Seong Wook Jeong ,Hyung Gon Lee pp.78-82

(The)effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol Dong Hun Chung ,Nan Sook Kim ,Mi Kyoung Lee ,Hee-kyung Jo pp.83-89

Cardiovascular and arousal responses to single-lumen endotracheal and double-lumen endobronchial intubation in the normotensive and hypertensive elderly Kyung Yeon Yoo ,Cheol Won Jeong ,Woong Mo Kim ,Hyung Kon Lee ,Seongtae Jeong ,Seok Jae Kim ,Hong Beum Bae ,Dong Yun Lim ,Sung Su Chung pp.90-97

(The)effect of postoperative pain on postoperative blood loss after sequential bilateral total knee arthroplasty So Yeon Kim ,Yong Jun An ,Soo Hwan Kim ,Ha-Kyoung Kim ,Jeong Soo Park ,Yang-Sik Shin pp.98-102

Comparison of fentanyl and sufentanil added to 0.5% hyperbaric bupivacaine for spinal anesthesia in patients undergoing cesarean section Jung Hyang Lee ,Kum Hee Chung ,Jong Yun Lee ,Duk Hee Chun ,Hyeon Jeong Yang ,Tong Kyun Ko ,Wan Seop Yun pp.103-108

(The)effects of midazolam and sevoflurane on the GABA_A_ receptors with alternatively spliced variants of the γ2 subunit Woosik Eom ,Jung Min Lee ,Jeongmi Park ,Kyungho Choi ,Sung-Jun Jung ,Hee-Soo Kim pp.109-118

Anesthetic experience using total intra-venous anesthesia for a patient with Wolf-Hirschhorn syndrome :a case report Jae Ho Choi ,Jae Hwan Kim ,Young Cheol Park ,Woon Young Kim ,Yoon-Sook Lee pp.119-123

Anesthetic experience of a patient with Ohtahara syndrome :a case report Eun Mi Choi ,Kyeong Tae Min ,Jin Sun Cho ,Seung Ho Choi pp.124-127

Anesthetic considerations of percutaneous transcatheter aortic valve implantation :first attempt in Korea :a report of 2 cases Hyo Jung Son ,Hwa Mi Lee ,Ji Hyun Chin ,Dae Kee Choi ,Eun Ho Lee ,Ji Yeon Sim ,In Cheol Choi pp.128-133

Cervicogenic headache arising from hidden metastasis to cervical lymph node adjacent to the superficial cervical plexus :a case report Hwan Hee Kim ,Yong Chul Kim ,Yong Hee Park ,Jin Woo Park ,Jae-Hun Kim ,Soo-Young Park ,Sang Chul Lee pp.134-137

Repetitive single subarachnoid injections for trial administration of the intrathecal morphine pump in patients withintractable non-cancer pain :a case report Jae-Woo Lee ,Kyung Ream Han ,Seung-Ho Kim ,Ji-Young Lee ,Do-Wan Kim ,Chan Kim pp.138-141

Mechanism of emergence agitation induced by sevoflurane anesthesia 김재환 pp.73-74

참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Propofol 네이버 미소장
2 Physical properties and stability of two emulsion formulations of propofol 네이버 미소장
3 The Effect of Lidocaine on the Globule Size Distribution of Propofol Emulsions 네이버 미소장
4 Propofol: The Challenges of Formulation 네이버 미소장
5 Klein J, Huisman I, Menon AG, Leenders CM, van Eeghem KH, Vos MG, et al. Postoperative infection due to contaminated propofol. Ned Tijdschr Geneeskd 2010; 154: A767. 미소장
6 Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors. 네이버 미소장
7 Pharmacokinetics and pharmacodynamics of a new reformulated microemulsion and the long-chain triglyceride emulsion of propofol in beagle dogs. 네이버 미소장
8 Pharmacokinetics and pharmacodynamics of propofol microemulsion and lipid emulsion after an intravenous bolus and variable rate infusion. 네이버 미소장
9 Anesthetic Properties of a Propofol Microemulsion in Dogs 네이버 미소장
10 Pain on injection with microemulsion propofol. 네이버 미소장
11 A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: A prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients 네이버 미소장
12 Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil. 네이버 미소장
13 Prevention of Pain on Injection with Propofol: A Quantitative Systematic Review 네이버 미소장
14 Reducing pain during propofol injection: the role of the solvent. 네이버 미소장
15 Physicochemical Properties, Pharmacokinetics, and Pharmacodynamics of a Reformulated Microemulsion Propofol in Rats 네이버 미소장
16 Effect of prior administration of cold saline on pain during propofol injection 네이버 미소장
17 The Pharmacodynamic Effects of a Lower-Lipid Emulsion of Propofol: A Comparison with the Standard Propofol Emulsion 네이버 미소장
18 The control of pain in peripheral tissue by opioids. 네이버 미소장
19 Optimal dose of sufentanil in children for intubation after sevoflurane induction without neuromuscular block 네이버 미소장
20 Acute respiratory arrest and rigidity after anesthesia with sufentanil: a case report. 네이버 미소장
21 Miller R, Fleisher LA, Eriksson LI. Miller's anesthesia. 7th ed. Philadelphia, Churchill-Livingstone Elsevier. 2010, pp 769-814. 미소장
22 Tussive effect of a fentanyl bolus administered through a central venous catheter. 네이버 미소장
23 Kinoshita H, Kakutani T, Minonishi T, Mizumoto K, Hatano Y. Transient phlebitis induced by a bolus injection of propofol. J Anesth 2006; 20: 74-5. 미소장
24 Prevention of pain on injection of propofol: a comparison of lidocaine with alfentanil. 네이버 미소장

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