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The anti-inflammatory activities of a prepared isoegomaketone 3a and its derivatives 3b-3f were evaluated in RAW 264.7 cells. Among these, the compound 3d was displayed the most potent inhibitory activities against production of nitric oxide, monocyte chemoattractant protein-1 and interleukin-6. Based on these results, the abilities of compounds 3a-3f to modulate NF-κB and AP-1-mediated gene transcription using a luciferase reporter assay were investigated. The transcriptional activities of NF-κB and AP-1 decreased when pretreated with 3a-3f. Interestingly, at 10 μM, compound 3d markedly suppressed the lipopolysaccharide-induced NF-κB and activator protein-1 DNA binding activities. Some preliminary structure-activity relationships were proposed that may provide a direction for further study.

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기사명 저자명 페이지 원문 목차
Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of artemisia maritima L. Abdul Jabbar Shah, Anwarul-Hassan Gilani, Kanza Abbas, Munawwer Rasheed, Amir Ahmed, Viqar Uddin Ahmad pp.1227-1238

Synthesis, anti-inflammatory, analgesic, and antibacterial activities of some triazole, triazolothiadiazole, and triazolothiadiazine derivatives Mostafa A. Hussein, Refaat M. Shaker, Mohammed A. Ameen, Mohammed F. Mohammed pp.1239-1250

Synthesis, antioxidant and antimicrobial evaluation of simple aromatic esters of ferulic acid Burcu Çaliskan Ergün, Tülay Çoban, Fatma Kaynak Onurdag, Erden Banoglu pp.1251-1261

Anti-inflammatory cembranoids from the Formosan soft coral sinularia discrepans Yi Lu, Huey-Jen Su, Yung-Husan Chen, Zhi-Hong Wen, Jyh-Horng Sheu, Jui-Hsin Su pp.1263-1267

Stereoselective total synthesis of (+)-licochalcone E Zhiguo Liu, Zengtao Wang, Goo Yoon, Seung Hoon Cheon pp.1269-1276

Biological evaluation of isoegomaketone isolated from perilla frutescens and its synthetic derivatives as anti-inflammatory agents Yong Dae Park, Chang Hyun Jin, Dae Seong Choi, Myung-Woo Byun, Il Yun Jeong pp.1277-1282

Carboxymethyl flavonoids and a monoterpene glucoside from selaginella moellendorffii Hong-Sheng Wang, Ling Sun, Yue-Hu Wang, Ya-Na Shi, Gui-Hua Tang, Fu-Wei Zhao, Hong-Mei Niu, Chun-Lin Long, Ling Li pp.1283-1288

Phenolic constituents of acorus gramineus Cheol Hyeong Park, Ki Hyun Kim, Il Kyun Lee, Seung Young Lee, Sang Un Choi, Jei Hyun Lee, Kang Ro Lee pp.1289-1296

One new pregnane glycoside from the seeds of cultivated brucea javanica Jie-Qing Liu, Cui-Fang Wang, Xing-Yao Li, Jian-Chao Chen, Yan Li, Ming-Hua Qiu pp.1297-1300

Effects of water-soluble tacrolimus-PEG conjugate on insulin-dependent diabetes mellitus and systemic lupus erythematosus DuBok Choi, Bok Hee Kim, Myung Koo Lee, Hoon Cho pp.1301-1310

Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry Hang Ruan, Zhen Zhang, Xin-fang Liang, Yan Fu, Mei-qin Su, Qi-lin Liu, Xiu-min Wang, Xuan Zhu pp.1311-1321

Retrospective study on antihyperlipidemic efficacy and safety of simvastatin, ezetimibe and their combination in Korean adults Young-Hee Lee, Mi-Jeong Kim, Chang-Ik Choi, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee pp.1331-1337

Effect of saucerneol D on melanin production in cAMP-elevated melanocytes Ji Young Yun, Eunmiri Roh, Jong-Keun Son, Seung Ho Lee, Chang-Seob Seo, Bang Yeon Hwang, Sang-Bae Han, Youngsoo Kim pp.1339-1345

Effects of impressic acid from acanthopanax koreanum on NF-κB and PPARγ activities Jeong Ah Kim, Seo Young Yang, Seok Bean Song, Young Ho Kim pp.1347-1351

Antimicrobial activity of commonly used antibiotics and DNA fingerprint analysis of pseudomonas aeruginosa obtained from clinical isolates and unchlorinated drinking water in Korea, 2010 Jung Rae Kim, Do Kyung Lee, Hyang Mi An, Mi Jin Kim, Si Won Lee, Min Kyeong Cha, Kang Oh Lee, Nam Joo Ha pp.1353-1361

Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells Kyung Hun Kim, Hye Sook Seo, Han Seok Choi, InHwa Choi, Yong Cheol Shin, Seong-Gyu Ko pp.1363-1372

Inhibitory effect of 2-arylbenzofurans from the mori cortex radicis(moraceae) on oxygen glucose deprivation(OGD)-induced cell death of SH-SY5Y cells Hak Ju Lee, Da Hyun Lyu, Uk Koo, Sung-Jin Lee, Seong Su Hong, Kemok Kim, Kyeong Ho Kim, Dongho Lee, Woongchon Mar pp.1373-1380

Inhibition of osteoblastic differentiation by warfarin and 18-α-glycyrrhetinic acid Hyung Min Jeong, Dong Hyeok Cho, Yun Hye Jin, Jin Ook Chung, Min Young Chung, Dong Jin Chung, Kwang Youl Lee pp.1381-1387

Induction of secretory leukocyte protease inhibitor(SLPI) in estradiol valerate(EV) induced polycystic ovary Jin-Ju Park, Chun Sik Bae, Baik-Dong Choi, Soon-Jeong Jeong, Guanlin Wang, Do-Seon Lim, Byung-Ock Kim, Young-Sik Cho, Sun-Ju Kim, Moon-Jin Jeong pp.1389-1397

1-oxoeudesm-11(13)-ene-12,8α-lactone-induced apoptosis via ROS generation and mitochondria activation in MCF-7 cells Min Cui, Yahong Zhang, Shanshan Liu, Weidong Xie, Mei Ji, Hongxiang Lou, Xia Li pp.1323-1329

참고문헌 (12건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 An efficient conversion of ketones to .alpha.,.beta.-unsaturated ketones 네이버 미소장
2 Toll-like receptors in the induction of the innate immune response. 네이버 미소장
3 Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters. 네이버 미소장
4 Principles of interleukin (IL)-6-type cytokine signalling and its regulation. 네이버 미소장
5 Isoegomaketone inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages through the heme oxygenase-1 induction and inhibition of the interferon-beta-STAT-1 pathway. 네이버 미소장
6 Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation 네이버 미소장
7 Manning, A. M. and Mercurio, F., Transcription inhibitors in inflammation. Expert Opin. Investig. Drugs, 6, 555-567 (1997). 미소장
8 Melgarejo, E., Medina, M. A., Sanchez-Jimenez, F., and Urdiales, J. L., Monocyte chemoattractant protein-1: a key mediator in inflammatory processes. Int. J. Biochem. Cell Biol., 41, 998-1001 (2009). 미소장
9 O'Neill, L. A., Targeting signal transduction as a strategy to treat inflammatory diseases. Nat. Rev. Drug Discov., 5, 549-563 (2006). 미소장
10 Biotechnology Journal 10/2010 네이버 미소장
11 Reinhart, K. and Karzai, W., Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned. Crit. Care Med., 29, S121-S125 (2001). 미소장
12 Shaulian, E. and Karin, M., AP-1 as a regulator of cell life and death. Nat. Cell Biol., 4, E131-E136 (2002). 미소장

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