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한국학술지인용색인(NRF)
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본 연구에서는 채진목(Amelanchier asiatica)의 항산화 활성과 xanthine oxidase, angiotensin converting enzyme 그리고 elastase 저해활성 등의 생리활성 효과를 조사해 보았다. 채진목 열매추출물에는 17.6 mg/g의 페놀성 물질이 함유되어 있으며,추출물의 항산화 활성 실험에서 전자공여능은 채진목 열매 추출물을 50 μg/mL 이상으로 처리했을 때, 50% 이상의 효과를 보였으며, 200 μg/mL 이상 처리 하였을 때는 90% 이상의 전자공여능을 보였다. 또한 ABTS [2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid] radical cation decolorization 측정과 thiobarbituric acid reaction substance 측정에서도 각각 200 μg/mL 이상 처리하였을 때, 98%와 73%의 우수한 항산화력을 보였으며, antioxidant protection factor 측정에서는 1.03 PF의 효과를 보였다. XOase 저해활성 측정에서는 200 μg/mL 이상 처리하였을 때, 15% 이상의 저해활성을 나타냈으며, ACE 저해성에서는 150 μg/mL에서 50% 이상, 200 μg/mL에서 82% 이상의 우수한 저해활성을 확인할 수 있었다. Elastase 저해활성에서는 50, 100, 150, 200 μg/mL 첨가 시 각각 3.9, 18.8, 32.1, 41.3%의 저해율을 보여 농도가 증가함에 따라 그 효과또한 증가함을 알 수 있었다. 또한 대조구인 Vit C가 200 μg/mL 첨가 시 12.6%의 낮은 저해율을 보여 상대적으로 그 효과의 우수함을 알 수 있었다. 본 연구의 결과로 채진목의 항산화활성 및 통풍과 고혈압, 주름개선에 도움을 줄 수 있는 기능성 식품 및 기능성 화장품의 개발 가능성이 확인되었으며, 안전한 천연 기능성소재로서의 활용을 기대 할 수 있게 하였다.
Amelanchier asiatica fruits have been used as a traditional medical food. This research was investigated to assess angiotensin converting enzyme, xanthine oxidase (XOase) and elastase inhibitory activity and antioxidant activities. The content of total phenolic compounds in A. asiatica fruits extracts was 17.6mg/mL. In extracts, the electron donating ability by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging test of A. asiatica fruits extracts was 90.18% at 200 μg/mL. The 2,2'- azinobis(3-ethylbenzothiazoline-6-sulfonic acid radical decolorization of A. asiatica fruits extracts was 98.81% at 200 μg/mL. The inhibition rate of the antioxidant protection factor was 1.03, and thiobarbituric acid reactive substance was 73.27% at 200 μg/mL. The XOase inhibition activity of A.asiatica fruits extracts of showed to be 13.19% at 200 μg/mL. The angiotensin converting enzyme activity was significantly inhibited by A. asiatica fruits extracts as 82.52% inhibitory rate at 200 μg/mL. Elastase inhibitory activity in the A. asiatica fruits extracts (41.48% at 200 μg/mL) was higher than vitamin C (12.8% at 200 μg/mL). These results suggests that A. asiatica fruits extracts have the greatest property as a functional food and functional cosmetic source.
Amelanchier asiatica fruits have been used as a traditional medical food. This research was investigated to assess angiotensin converting enzyme, xanthine oxidase (XOase) and elastase inhibitory activity and antioxidant activities. The content of total phenolic compounds in A. asiatica fruits extracts was 17.6mg/mL. In extracts, the electron donating ability by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging test of A. asiatica fruits extracts was 90.18% at 200 μg/mL. The 2,2'- azinobis(3-ethylbenzothiazoline-6-sulfonic acid radical decolorization of A. asiatica fruits extracts was 98.81% at 200 μg/mL. The inhibition rate of the antioxidant protection factor was 1.03, and thiobarbituric acid reactive substance was 73.27% at 200 μg/mL. The XOase inhibition activity of A.asiatica fruits extracts of showed to be 13.19% at 200 μg/mL. The angiotensin converting enzyme activity was significantly inhibited by A. asiatica fruits extracts as 82.52% inhibitory rate at 200 μg/mL. Elastase inhibitory activity in the A. asiatica fruits extracts (41.48% at 200 μg/mL) was higher than vitamin C (12.8% at 200 μg/mL). These results suggests that A. asiatica fruits extracts have the greatest property as a functional food and functional cosmetic source.
권호기사
참고문헌 (33건) : 자료제공( 네이버학술정보 )
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