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Osteoclasts are multinucleated cells that are formed by the fusion of pre-fusion osteoclasts (pOCs). The fusion of pOCs is known to be important for osteoclastic bone resorption. Here, we examined the effect of IFN-γ on the fusion of pOCs. IFN-γ greatly increased the fusion of pOCs in a dose-dependent manner. Furthermore, IFN-γ induced pOC fusion even in hydroxyapatite- coated plates used as a substitute for bone. The resorption area of pOCs stimulated with IFN-γ was significantly higher than that of the control cells. IFN-γ induced the expression of dendritic cell-specific transmembrane protein (DC-STAMP), which is responsible for the fusion of pOCs. IFN-γ enhanced DC-STAMP expression in a dose-dependent manner. The mRNA expression of c-Fos and nuclear factor of activated T cells (NFAT) c1 was enhanced in the pOCs treated with IFN-γ. Taken together, these results provide a new insight into the novel role of IFN-γ on the fusion of pOCs.

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Biological activities of lignin hydrolysate-related compounds Siseon Lee, Ajay Kalanjana Monnappa, Robert J. Mitchell pp.265-274

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Effect of interferon-γ on the fusion of mononuclear osteoclasts into bone-resorbing osteoclasts Jeung Woo Kim, Myeung Su Lee, Chang Hoon Lee, Ha Young Kim, Soo Uk Chae, Han Bok Kwak, Jaemin Oh pp.281-286

FGF-2 inhibits TNF-α mediated apoptosis through up-regulation of Bcl2-A1 and Bcl-xL in ATDC5 cells Hey-Ryun Kim, Youn-Moo Heo, Kyoung-Il Jeong, Yong-Min Kim, Hae Lan Jang, Kwang-Yeol Lee, Chang-Yeol Yeo, Sung Hoon Kim, Hak-Kyo Lee, Seung-Ryul Kim … [et al.] pp.287-292

Molecular characterization and immunohistochemical localization of a mitogen-activated protein kinase, Accp38b, from Apis cerana cerana Liang Zhang, Fei Meng, Yuzhen Li, Mingjiang Kang, Xingqi Guo, Baohua Xu pp.293-298

High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression Jeong-A Park, Young-Eun Kim, Yang-Hwa Ha, Hyung-Joo Kwon, Younghee Lee pp.299-304

Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population Dankyu Yoon, Hyo-Jeong Ban, Young Jin Kim, Eun-Jin Kim, Hyung-Cheol Kim, Bok-Ghee Han, Jung-Won Park, Soo-Jong Hong, Sang-Heon Cho, Kiejung Park … [et al.] pp.305-310

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma Jun Ho Park, Jong Won Kim, Chang-Min Lee, Yeong Dae Kim, Sung Woon Chung, In Duk Jung, Kyung Tae Noh, Jin Wook Park, Deok Rim Heo, Yong Kyoo Shin … [et al.] pp.311-316

Protein phosphorylation on tyrosine restores expression and glycosylation of cyclooxygenase-2 by 2-deoxy-D-glucose-caused endoplasmic reticulum stress in rabbit articular chondrocyte Seon-Mi Yu, Song-Ja Kim pp.317-322

참고문헌 (29건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Bone Resorption by Osteoclasts 네이버 미소장
2 Osteoclast differentiation and activation 네이버 미소장
3 Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. 네이버 미소장
4 Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone. 네이버 미소장
5 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. 네이버 미소장
6 TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. 네이버 미소장
7 Therapeutic Approaches to Bone Diseases 네이버 미소장
8 TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells. 네이버 미소장
9 Matsuo, K., Owens, J. M., Tonko, M., Elliott, C., Chambers, T. J. and Wagner, E. F. (2000) Fosl1 is a transcription target of c-Fos during osteoclast differentiation. Nat. Genet. 24, 184-187. 미소장
10 Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T. and Taniguchi, T. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901. 미소장
11 Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. 네이버 미소장
12 The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. 네이버 미소장
13 Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. 네이버 미소장
14 Takayanagi, H. (2005) Mechanistic insight into osteoclast differentiation in osteoimmunology. J. Mol. Med. 83, 170-179. 미소장
15 Endocrinology Reviewers, 2007 네이버 미소장
16 Effect of CD44 deficiency on in vitro and in vivo osteoclast formation 네이버 미소장
17 The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. 네이버 미소장
18 Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. 네이버 미소장
19 v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. 네이버 미소장
20 DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. 네이버 미소장
21 GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway. 네이버 미소장
22 RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β 네이버 미소장
23 T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. 네이버 미소장
24 IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. 네이버 미소장
25 Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. 네이버 미소장
26 DC‐STAMP, a novel multimembrane‐spanning molecule preferentially expressed by dendritic cells 네이버 미소장
27 Shaw, J. P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A. and Crabtree, G. R. (1998) Identification of a putative regulator of early T cell activation genes. Science 241, 202-205. 미소장
28 Skurkovich, S. V. and Eremkina, E. I. (1975) The probable role of interferon in allergy. Ann. Allergy 35, 356-360. 미소장
29 Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases 네이버 미소장

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