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Adiponectin may affect bone through interactions with two known receptors, adiponectin receptors (ADIPOR) 1 and 2. We examined the association between polymorphisms of ADIPOR1 and ADIPOR2 and bone mineral density (BMD) in postmenopausal Korean women. Six polymorphisms in ADIPOR1 and four polymorphisms in ADIPOR2 were selected and genotyped in all study participants (n = 1,329). BMD at the lumbar spine and femur neck were measured using dual-energy X-ray absorptiometry. Lateral thoracolumbar (T4-L4) radiographs were obtained for vertebral fracture assessment and the occurrence of non-vertebral fractures examined using self-reported data. P values were adjusted for multiple testing using Bonferroni correction (Pcorr ). ADIPOR1 rs16850799 and rs34010966 polymorphisms were significantly associated with femur neck BMD (Pcorr = 0.036 in the dominant model; Pcorr = 0.024 and Pcorr = 0.006 in the additive and dominant models, respectively). Subjects with the rare allele of each polymorphism had lower BMD, and association of rs34010966 with BMD showed a gene dosage effect. However, ADIPOR2 single nucleotide polymorphisms and haplotypes were not associated with BMD at any site. Our results suggest that ADIPOR1 polymorphisms present a useful genetic marker for BMD in postmenopausal Korean women.

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기사명 저자명 페이지 원문 목차
Dendroaspis natriuretic peptide regulates the cardiac L-type Ca^2+^ channel activity by the phosphorylation of α_1c_ proteins Seon-Ah Park, Tae-Geun Kim, Myung-Kwan Han, Ki-Chan Ha, Sung-Zoo Kim, Yong-Geun Kwak pp.363-368

Anew synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone(DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells Young Han Lee, Seung-Hyun Jeon, Se Hyun Kim, Changyoun Kim, Seung-Jae Lee, Dongsoo Koh, Yoongho Lim, Kyooseob Ha, Soon Young Shin pp.369-377

12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity Jin-Wook Lee, Ho-Cheol Ryu, Yee Ching Ng, Cheolmin Kim, Jun-Dong Wei, Vikineswary Sabaratnam, Jae-Hong Kim pp.378-386

Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression Yuan-Guo Wang, Seok-Jun Kim, Jung-Hwan Baek, Hyun-Woo Lee, Seo-Young Jeong, Kyung-Hee Chun pp.387-393

Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women Ha Young Kim, Joo-Yeon Hwang, Bok-Ghee Han, Jong-Young Lee, Eui Kyun Park, Beom-Jun Kim, Seung Hun Lee, Ghi Su Kim, Shin-Yoon Kim, Jung-Min Koh pp.394-402

Apriming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection Siriporn Chamniansawat, Sukumal Chongthammakun pp.403-411

참고문헌 (43건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis 네이버 미소장
2 Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. 네이버 미소장
3 Ast G. How did alternative splicing evolve? Nat Rev Genet 2004;5:773-82 미소장
4 Haploview: analysis and visualization of LD and haplotype maps. 네이버 미소장
5 Adiponectin is associated with low bone mineral density in elderly men. 네이버 미소장
6 Adiponectin and its receptors are expressed in bone-forming cells. 네이버 미소장
7 Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes 네이버 미소장
8 Insulin Increases Histomorphometric Indices of Bone Formation In Vivo 네이버 미소장
9 Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. 네이버 미소장
10 De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 2005;16:1330-8 미소장
11 Ewing B, Hillier L, Wendl MC, Green P. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res 1998;8:175-85 미소장
12 Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. 네이버 미소장
13 Vertebral Fracture Assessment Using a Semiquantitative Technique 네이버 미소장
14 Aromatase activity and bone homeostasis in men. 네이버 미소장
15 Consed: a graphical tool for sequence finishing. 네이버 미소장
16 Insulin promotes growth of the cultured rat osteosarcoma cell line UMR-106-01: an osteoblast-like cell. 네이버 미소장
17 Cross-calibration of Bone Mineral Density between Two Different Dual X-ray Absorptiometry Systems: Hologic QDR 4500-A and Lunar EXPERT-XL 소장
18 Adiponectin is Associated with Bone Mineral Density in Perimenopausal Women 네이버 미소장
19 Jurimae J, Jurimae T. Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women. Osteoporos Int 2007;18:1253-9 미소장
20 Assessing Vertebral Fractures 네이버 미소장
21 Identification of adiponectin and its receptors in human osteoblast-like cells and association of T45G polymorphism in exon 2 of adiponectin gene with lumbar spine bone mineral density in Korean women. 네이버 미소장
22 Adiponectin as a novel determinant of bone mineral density and visceral fat. 네이버 미소장
23 Allelic discrimination using fluorogenic probes and the 5' nuclease assay 네이버 미소장
24 Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway 네이버 미소장
25 Genetic Factors And Osteoporotic Fractures In Elderly People 네이버 미소장
26 Osteophyte formation in the vertebral column: a review of the etiologic factors--Part II. 네이버 미소장
27 Status of infection surveillance and control programs in the United States, 1992-1996 네이버 미소장
28 Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast 네이버 미소장
29 Contribution of genetic and environmental effects to postural balance in older female twins. 네이버 미소장
30 Determinants of total body and regional bone mineral density in normal postmenopausal women--a key role for fat mass. 네이버 미소장
31 Circulating insulin levels are related to bone density in normal postmenopausal women. 네이버 미소장
32 Relationships between fat and bone. 네이버 미소장
33 Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. 네이버 미소장
34 Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. 네이버 미소장
35 Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. 네이버 미소장
36 Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. 네이버 미소장
37 A new statistical method for haplotype reconstruction from population data. 네이버 미소장
38 Shared genetic and environmental effects on strength and power in older female twins. 네이버 미소장
39 Heritability of BMD of femoral neck and lumbar spine: a multivariate twin study of Finnish men. 네이버 미소장
40 In vitro and in vivo effects of adiponectin on bone. 네이버 미소장
41 Wright M, De Geus E, Ando J, Luciano M, Posthuma D, Ono Y, Hansell N, Van Baal C, Hiraishi K, Hasegawa T, Smith G, Geffen G, Geffen L, Kanba S, Miyake A, Martin N, Boomsma D. Genetics of cognition: outline of a collaborative twin study. Twin Res 2001;4:48-56 미소장
42 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. 네이버 미소장
43 Relationship between leptin levels and bone mineral density in the elderly. 네이버 미소장

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