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Background: Chronic obstructive pulmonary disease (COPD) is now regarded as a heterogenous disease, with variable phenotypes. Acute exacerbation of COPD is a major event that alters the natural course of disease. The frequency of COPD exacerbation is variable among patients. We analyzed clinical features, according to the frequency of acute exacerbation in COPD.

Methods: Sixty patients, who visited Gyeongsang National University Hospital from March 2010 to October 2010,were enrolled. Patients were divided into two groups, according to their frequency of acute exacerbation. Frequent exacerbator is defined as the patient who has two or more exacerbation per one year. We reviewed patients’medical records and investigated modified Medical Research Council (MMRC) dyspnea scale, smoking history and frequency of acute exacerbation. We also conducted pulmonary function test and 6-minute walking test, calculated body mass index, degree of airway obstruction and dyspnea and exercise capacity (BODE) index and measured CD146 cells in the peripheral blood.

Results: The number of frequent exacerbators and infrequent exacerbators was 20 and 40, respectively. The frequent exacerbator group had more severe airway obstruction (forced expiratory volume in one second [FEV1], 45% vs.

65.3%, p=0.001; FEV1/forced vital capacity, 44.3% vs. 50.5%, p=0.046). MMRC dyspnea scale and BODE index were significantly higher in the frequent exacerbator group (1.8 vs. 1.1, p=0.016; 3.9 vs. 2.1, p=0.014, respectively).

The fraction of CD146 cells significantly increased in the frequent exacerbator group (2.0 vs. 1.0, p＜0.001).

Conclusion: Frequent exacerbator had more severe airway obstruction and higher symptom score and BODE index.

However, circulating endothelial cells measured by CD146 needed to be confirmed in the future.

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Clinical features according to the frequency of acute exacerbation in COPD Seung Jun Lee, Seung Hun Lee, Yu Eun Kim, Yu Ji Cho, Yi Yeong Jeong, Ho Cheol Kim, Jin Hyun Kim, Jin Jong You, Chul-Ho Yoon, Jong Deog Lee … [et al.] pp.367-373

The current status of BCG vaccination in young children in South Korea Hyejon Lee, Hazel M. Dockrell, Deok Ryun Kim, Sian Floyd, Sue Yeon Oh, Jin Bum Lee, Hee Jin Kim pp.374-380

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참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Management in ekonomija: ali je to dvoje ali eno? (Elementi in razumevanje postocializma in managerske revolucije) = Management and Economy: Are They the Same Or Not? 네이버 미소장
2 Phenotypes of chronic obstructive pulmonary disease. 네이버 미소장
3 Health-related quality of life is related to COPD disease severity. 네이버 미소장
4 The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. 네이버 미소장
5 A Multidimensional Grading System (BODE Index) as Predictor of Hospitalization for COPD 네이버 미소장
6 Frequent chronic obstructive pulmonary disease exacerbators: how much real, how much fictitious? 네이버 미소장
7 Circulating endothelial progenitor cells and chronic pulmonary diseases. 네이버 미소장
8 Abnormal levels of circulating endothelial progenitor cells during exacerbations of COPD. 네이버 미소장
9 Susceptibility to exacerbation in chronic obstructive pulmonary disease. 네이버 미소장
10 Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study. 네이버 미소장
11 Impact of COPD Exacerbations on Patient-Centered Outcomes 네이버 미소장
12 Correlation of frequency of exacerbations with the BODE index in COPD patients. 네이버 미소장
13 COPD exacerbations . 2: aetiology. 네이버 미소장
14 Changes in forced expiratory volume in 1 second over time in COPD. 네이버 미소장
15 Au DH, Bryson CL, Chien JW, Sun H, Udris EM, Evans LE, et al. The effects of smoking cessation on the risk of chronic obstructive pulmonary disease exacerbations. J Gen Intern Med 2009;24:457-63. 미소장
16 Circulating endothelial cells: A novel marker of endothelial damage 네이버 미소장
17 Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. 네이버 미소장
18 Circulating endothelial cells in pulmonary hypertension. 네이버 미소장
19 Circulating endothelial cells in acute ischaemic stroke. 네이버 미소장
20 Circulating endothelial cells in Behçet's disease with cerebral thrombophlebitis. 네이버 미소장
21 Clancy RM. Circulating endothelial cells and vascular injury in systemic lupus erythematosus. Curr Rheumatol Rep 2000;2:39-43. 미소장
22 Circulating endothelial cells in patients with septic shock. 네이버 미소장
23 Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients 네이버 미소장
24 Pulmonary vascular involvement in COPD. 네이버 미소장

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