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Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used in oriental medicine to treat various symptoms in Korea, however, several herbs have been reported to induce liver injury. We report a case of toxic hepatitis induced by Hovenia dulcis in a 3-year-old boy. He complained of nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with hovenia dulcis for about 1 year prior to presentation. A diagnosis of toxic hepatitis was made based on his history, laboratory data, viral markers, ultrasonography, and biopsied liver tissue. We administered supportive management for acute fulminant hepatitis but his symptoms and liver function progressed. He was transferred to another hospital for further evaluation and consideration for liver transplantation. Because acute liver failure due to herbs or dietary supplement taken for a long time is often fetal, it is important to make early diagnosis and stop taking the drug as soon as drug induced liver injury is suspected.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Strategy to overcome drug resistance that develops during treatment of chronic hepatitis B in children Suk Jin Hong, Byung-Ho Choe pp.63-73
Therole of inflammatory mediators in the pathogenesis of nonalcoholic fatty liver disease Joon Sung Kim pp.74-78

How to manage the pediatric nutritional support team : updates Hye Ran Yang pp.79-84

Comparison of four commercial ELISA kits and in-house immunoblotting for diagnosis of Helicobacter pylori infection Hoar Lim Jeong, Yang-Sook Jung, Jin-Su Jun, Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn … [et al.] pp.85-90
Cytomegalovirus infection in infantile hepatitis So Young Na pp.91-99

Acase of congenital paraesophageal hiatal hernia in infancy Won-Nyung Jang, In-Su Park, Kwi-Won Park, Seon-Young Yoo, Jin Lee, Sang-Hee Cho pp.100-104
Endoscopic hemostasis for bleeding gastric ulcer caused by ibuprofen in a 16-month-old infant So Young Na pp.105-110
Apediatric case of toxic hepatitis induced by hovenia dulcis Yun Ji Kim, Seung Lok Ryu, Jae Won Shim, Duk Soo Kim, Jung Yeon Shim, Moon Soo Park, Hye Lim Jung pp.111-116
Acase of idiopathic congenital neonatal cholestasis in a patient with down syndrome Tae-eon Huh, Hyun Jeong Do, Ji Sook Park, Jung Sook Yeom, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan-Hoo Park, Hyang Ok Woo, Hee-Shang Youn pp.117-121
Benign recurrent intrahepatic cholestasis with a single heterozygote mutation in the ATP8B1 gene Yun Seok Lee, Mi Jin Kim, Chang Seok Ki, Yoo Min Lee, Yoon Lee, Yon Ho Choe pp.122-126

참고문헌 (17건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 A case of acute cholestatic hepatitis induced by Corydalis speciosa Max 네이버 미소장
2 Drug-induced liver diseases 네이버 미소장
3 Clinical characteristics of 159 cases of acute toxic hepatitis 네이버 미소장
4 Acute liver failure in children 소장
5 Treatment of chronic liver injuries in mice by oral administration of ethanolic extract of the fruit of Hovenia dulcis. 네이버 미소장
6 Liver Transplantation for Acute Toxic Hepatitis due to Herbal Medicines and Preparations 소장
7 The Assessment of Toxic Liver Injury 소장
8 Toxic hepatitis associated with Polygoni multiflori 네이버 미소장
9 Criteria of drug-induced liver disorders: Report of an International Consensus Meeting 네이버 미소장
10 Hepatotoxicity of herbal remedies 네이버 미소장
11 Hovenia dulcis--an Asian traditional herb. 네이버 미소장
12 (백선 복용 후 발생한 전격성 간부전 1예) 네이버 미소장
13 Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct. 네이버 미소장
14 Drug‐induced liver injury: Mechanisms and test systems 네이버 미소장
15 Herbal Hepatotoxicity 네이버 미소장
16 Shim JO. Diagnosis and management of acute liver failure in children. Korean J Pediatr Gastroenterol Nutr 2008;11(Suppl 2):50-8 . 미소장
17 Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. 네이버 미소장

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