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Background: The hypothalamus, the center for body weight regulation, can sense changes in blood glucose level based on ATP-sensitive potassium (KATP) channels in the hypothalamic neurons. We hypothesized that a lack of glucose sensing in the hypothalamus affects the regulations of appetite and body weight.

Methods: To evaluate this hypothesis, the responses to glucose loading and high fat feeding for eight weeks were compared in Kir6.2 knock-out (KO) mice and control C57BL/6 mice, because Kir6.2 is a key component of the KATP channel.

Results: The hypothalamic neuropeptide Y (NPY) analyzed one hour after glucose injection was suppressed in C57BL/6 mice, but not in Kir6.2 KO mice, suggesting a blunted hypothalamic response to glucose in Kir6.2 KO mice. The hypothalamic NPY expression at a fed state was elevated in Kir6.2 KO mice and was accompanied with hyperphagia. However, the retroperitoneal fat mass was markedly decreased in Kir6.2 KO mice compared to that in C57BL/6 mice. Moreover, the body weight and visceral fat following eight weeks of high fat feeding in Kir6.2 KO mice were not significantly different from those in control diet-fed Kir6.2 KO mice, while body weight and visceral fat mass were elevated due to high fat feeding in C57BL/6 mice.

Conclusion: These results suggested that Kir6.2 KO mice showed a blunted hypothalamic response to glucose loading and elevated hypothalamic NPY expression accompanied with hyperphagia, while visceral fat mass was decreased, suggesting resistance to diet-induced obesity. Further study is needed to explain this phenomenon.

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ATP-sensitive potassium channel-deficient mice show hyperphagia but are resistant to obesity Yeul Bum Park, Yun Jung Choi, So Young Park, Jong Yeon Kim, Seong Ho Kim, Dae Kyu Song, Kyu Chang Won, Yong Woon Kim pp.219-225

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Angiotensin Ⅱ inhibits insulin binding to endothelial cells Su-Jin Oh, Won-Chul Ha, Jee-In Lee, Tae-Seo Sohn, Ji-Hyun Kim, Jung-Min Lee, Sang- Ah Chang, Oak-Kee Hong, Hyun-Shik Son pp.243-247

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Chemerin : A Novel Link between Inflammation and Atherosclerosis? 이은정 pp.216-218

참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Socio-Economic Situation of Migrants and Their Access to and Need for Social Services 네이버 미소장
2 Central nervous system control of food intake. 네이버 미소장
3 Obesity wars: molecular progress confronts an expanding epidemic. 네이버 미소장
4 Harrold JA. Hypothalamic control of energy balance. Curr Drug Targets 2004;5:207-19. 미소장
5 Scarpace PJ, Matheny M, Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 2001;104:1111-7. 미소장
6 Minireview: nutrient sensing and the regulation of insulin action and energy balance. 네이버 미소장
7 Neuronal glucosensing: what do we know after 50 years? 네이버 미소장
8 Glucose-Sensing Neurons of the Hypothalamus 네이버 미소장
9 Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. 네이버 미소장
10 Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 2001;4: 507-12. 미소장
11 Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. 네이버 미소장
12 Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity 네이버 미소장
13 Gyte A, Pritchard LE, Jones HB, Brennand JC, White A. Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. J Neuroendocrinol 2007;19:941-51. 미소장
14 Altered dietary carbohydrates significantly affect gene expression of the major glucosensing components in Brockmann bodies and hypothalamus of rainbow trout. 네이버 미소장
15 Oleic acid directly regulates POMC neuron excitability in the hypothalamus. 네이버 미소장
16 ATP-regulated K+ channels in cardiac muscle. 네이버 미소장
17 Intracellular ATP directly blocks K+ channels in pancreatic B-cells. 네이버 미소장
18 Adenosine 5'-triphosphate-sensitive potassium channels. 네이버 미소장
19 Defective Insulin Secretion and Enhanced Insulin Action in KATPChannel-Deficient Mice 네이버 미소장
20 Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. 네이버 미소장
21 Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks? 네이버 미소장
22 Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. 네이버 미소장
23 Dissociation between sensing and metabolism of glucose in sugar sensing neurones. 네이버 미소장
24 Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. 네이버 미소장
25 ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. 네이버 미소장
26 Disruption of Sur2-Containing KATPChannels Enhances Insulin-Stimulated Glucose Uptake in Skeletal Muscle 네이버 미소장
27 Sarcolemmal ATP-Sensitive K + Channels Control Energy Expenditure Determining Body Weight 네이버 미소장
28 Exercise in a Pill: Feasibility of Energy Expenditure Targets 네이버 미소장

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