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Background: This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM).

Methods: A cross-sectional study was conducted in 192 type 2 diabetic patients. Plasma basal C-peptide and stimulated C-peptide were measured before and 6 minutes after intravenous injection of 1 mg glucagon. The relationship between C-peptide and microvascular complications was statistically analyzed.

Results: In patients with retinopathy, basal C-peptide was 1.9±1.2 ng/mL, and stimulated C-peptide was 2.7±1.6 ng/mL; values were significantly lower compared with patients without retinopathy (P=0.031 and P=0.002, respectively). In patients with nephropathy,basal C-peptide was 1.6±0.9 ng/mL, and stimulated C-peptide was 2.8±1.6 ng/mL; values were significantly lower than those recorded in patients without nephropathy (P=0.020 and P=0.026, respectively). Stimulated C-peptide level was associated with increased prevalence of microvascular complications. Age-, DM duration-, and hemoglobin A1c-adjusted odds ratios for retinopathy in stimulated C-peptide value were 4.18 (95% confidence interval [CI], 1.40 to 12.51) and 3.35 (95% CI, 1.09 to 10.25), respectively. The multiple regression analysis between nephropathy and C-peptide showed that stimulated C-peptide was statistically correlated with nephropathy (P=0.03).

Conclusion: In patients with type 2 diabetes, the glucagon stimulation test was a relatively simple method of short duration for stimulating C-peptide response. Stimulated C-peptide values were associated with microvascular complications to a greater extent than basal C-peptides.

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참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Kinetics of human connecting peptide in normal and diabetic subjects. 네이버 미소장
2 C-peptide metabolism and the liver. 네이버 미소장
3 Marx N, Walcher D. C-Peptide and atherogenesis: C-Peptide as a mediator of lesion development in patients with type 2 diabetes mellitus? Exp Diabetes Res 2008;2008:385108. 미소장
4 Role of C-Peptide in the Regulation of Microvascular Blood Flow 네이버 미소장
5 Relationship between C peptide and chronic complications in type-2 diabetes mellitus. 네이버 미소장
6 Serum C peptide level and renal function in diabetes mellitus. 네이버 미소장
7 Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. 네이버 미소장
8 Palmer JP, Fleming GA, Greenbaum CJ, Herold KC, Jansa LD, Kolb H, Lachin JM, Polonsky KS, Pozzilli P, Skyler JS, Steffes MW. C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 2004;53: 250-64. 미소장
9 Assessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications. 네이버 미소장
10 Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes. 네이버 미소장
11 Significance of C – Peptide in Type 2 Diabetics - A Study in the North Karnataka Population of India 네이버 미소장
12 Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. 네이버 미소장
13 Association between serum C-peptide levels and chronic microvascular complications in Korean type 2 diabetic patients. 네이버 미소장
14 Correlation between fasting serum C-peptide and B cell insulin secretory capacity in diabetes mellitus. 네이버 미소장
15 Pancreatic beta-cell function evaluated by intravenous glucose and glucagon stimulation. A comparison between insulin and C-peptide to measure insulin secretion. 네이버 미소장
16 Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. 네이버 미소장
17 C-peptide response to glucagon. A test for the residual beta-cell function in diabetes mellitus. 네이버 미소장
18 Relation between the serum level of C-peptide and risk factors for coronary heart disease and diabetic microangiopathy in patients with type-2 diabetes mellitus. 네이버 미소장
19 Relationships between beta-cell function and diabetic duration and albuminuria in type 2 diabetes mellitus. 네이버 미소장
20 Do high proinsulin and C-peptide levels play a role in autonomic nervous dysfunction?: Power spectral analysis in patients with non-insulin-dependent diabetes and nondiabetic subjects. 네이버 미소장
21 Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus. 네이버 미소장
22 The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XVI. The relationship of C-peptide to the incidence and progression of diabetic retinopathy. 네이버 미소장
23 Residual insulin production, glycaemic control and prevalence of microvascular lesions and polyneuropathy in long-term type 1 (insulin-dependent) diabetes mellitus. 네이버 미소장
24 Type 1 Diabetic Neuropathy and C-peptide 네이버 미소장
25 The beneficial effects of C-Peptide on diabetic polyneuropathy. 네이버 미소장

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