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Purpose: Pathologic complete response (pCR) has been suggested as a surrogate prognostic indicator in breast cancer patients treated with neoadjuvant chemotherapy. We assessed whether the likelihood of pCR and survival is associated with the immunohistochemistry-based molecular subtypes. Methods: We retrospectively analyzed the records of 276 patients with breast cancer who received neoadjuvant chemotherapy between January 2000 and January 2010. Patients were classified into four molecular subtypes based on the immunohistochemistry profiles of estrogen receptor, progesterone receptor, and HER2/neu. Logistic regression was used to analyze variables associated with pCR. Results: The pCR was achieved in 45 patients (16.3%). The triple negative subtype was an independent predictive factor for pCR (odds ratio, 3.21; 95% confidence interval, 1.20-8.56;p=0.020), and the ERBB-2 subtype showed a trend for higher pCR rates (odds ratio, 3.03; 95% confidence interval, 0.93-9.89; p=0.067) compared with the luminal A subtype. In 99 patients with HER2/neu-positive breast cancer, pCR rates were higher in those who received trastuzumab (31.7%) than those treated with conventional chemotherapy regimens (17.2%, p=0.023). The pCR was significantly associated with prolonged progressionfree survival (p=0.008). The triple negative subgroup had shorter progression-free survival (p=0.001) and overall survival (p=0.001) than the other subgroups. Conclusion: We demonstrated that the triple negative and ERBB-2 subtypes are more likely to obtain pCR when neoadjuvant chemotherapy is given, compared to the luminal A subtype. Despite the high pCR rate, the triple negative subtype showed worse survival outcomes, paradoxically, primarily due to patients who had residual disease.

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기사명 저자명 페이지 원문 목차
Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-D-glucose in combination therapy Fahimeh Aghaee, Jalil Pirayesh Islamian, Behzaad Baradaran pp.141-147

Breast cancer as an acquired thrombophilic state Vasiliki Kyriazi pp.148-156

Association of alanine-valine manganese superoxide dismutase gene polymorphism and microheterogeneity manganese superoxide dismutase activity in breast cancer and benign breast tissue Manar Atoum, Malak Abdel-Fattah, Nisreen Nimer, Saleem Abdel-Rahman, Sawsan A. Abdeldayem pp.157-161

Overexpression of cell cycle progression inhibitor geminin is associated with tumor stem-like phenotype of triple-negative breast cancer Maurizio Di Bonito, Monica Cantile, Francesca Collina, Giosuè Scognamiglio, Margherita Cerrone, Elvira La Mantia, Antonio Barbato, Giuseppina Liguori, Gerardo Botti pp.162-171

The glycolytic phenotype is correlated with aggressiveness and poor prognosis in invasive ductal carcinomas Se Min Jang, Hulin Han, Ki-Seok Jang, Young Jin Jun, Si-Hyong Jang, Kyueng-Whan Min, Min Sung Chung, Seung Sam Paik pp.172-180

The role of neutrophil estrogen receptor status on maspin synthesis via nitric oxide production in human breast cancer Karabi Ganguly Bhattacharjee, Mau Bhattacharyya, Umesh Chandra Halder, Pradipta Jana, Asru K. Sinha pp.181-188

The predictive value of serum HER2/neu for response to anthracycline-based and trastuzumab-based neoadjuvant chemotherapy Jung Sun Lee, Byung-Ho Son, Sei Hyun Ahn pp.189-196

Impact of triple-negative breast cancer phenotype on prognosis in patients with stage Ⅰ breast cancer Jeong Eun Kim, Heui June Ahn, Jin-Hee Ahn, Dok Hyun Yoon, Sung-Bae Kim, Kyung Hae Jung, Gyung-Yub Gong, Mi-Jung Kim, Byung Ho Son, Sei Hyun Ahn pp.197-202

Impact of immunohistochemistry-based molecular subtype on chemosensitivity and survival in patients with breast cancer following neoadjuvant chemotherapy Changhoon Yoo, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim, Hak-Hee Kim, Hee Jung Shin, Sei Hyun Ahn, Byung Ho Son, Gyungyub Gong pp.203-210

Efficiency of ultrasound and ultrasound-guided fine needle aspiration cytology in preoperative assessment of axillary lymph node metastases in breast cancer Aysegul Oz, Figen Basaran Demirkazik, Meltem Gulsun Akpinar, Isıl Soygur, Atac Baykal, Sevgen Celik Onder, Aysegul Uner pp.211-217

The risk factors influencing between the early and late recurrence in systemic recurrent breast cancer Won Jong Song, Kwan Il Kim, Sang Hyun Park, Mi Seon Kwon, Tae Hoon Lee, Heung Kyu Park, Jung Suk An pp.218-223

Long-term follow-up result of benign phyllodes tumor of the breast diagnosed and excised by ultrasound-guided vacuum-assisted breast biopsy Hai-Lin Park, Sea-Hyun Kwon, So Yong Chang, Jung Yin Huh, Ji-Young Kim, Jeong Yun Shim, Yoon Hee Lee pp.224-229

Development of novel breast cancer recurrence prediction model using support vector machine Woojae Kim, Ku Sang Kim, Jeong Eon Lee, Dong-Young Noh, Sung-Won Kim, Yong Sik Jung, Man Young Park, Rae Woong Park pp.230-238

Survey of the application of the Korean clinical practice recommendations on breast cancer treatment : the utility of the Korean breast cancer society guidelines Geumhee Gwak, Hae Kyung Lee, Hee Jung Kim, Si Youn Lee, Yong Lai Park, Jong Won Lee, Seung Gi Kim, Ho Huh, Hyukjai Shin, Je Ryong Kim … [et al.] pp.239-243

Breast metastasis from renal cell carcinoma : rare initial presentation of disease recurrence after 5 years Mervat Mahrous, Walid Al Morsy, Ahmed Al-Hujaily, Sameerah AL-Sulimani pp.244-247

Synchronous bilateral male breast cancer : a case report Woo-Young Sun, Ki-Hyeong Lee, Ho-Chang Lee, Dong-Hee Ryu, Jin-Woo Park, Hyo-Young Yun, Young-Jin Song pp.248-251

An incidentally detected breast cancer on Tc-99m MIBI cardiac scintigraphy Duray Seker, Gaye Seker, Emine Ozturk, Bahattin Bayar, Hakan Kulacoglu pp.252-254

MRI findings of large low-grade angiosarcoma of the breast with subsequent bone metastases : a case report Eleonora Cucci, Matteo Ciuffreda, Rosa Tambaro, Lorena Aquilani, Michele Barrassi, Giuseppina Sallustio pp.255-257

Giant breast involvement in acute lymphoblastic leukemia : MRI findings Isil Basara, Sebnem Orguc pp.258-260

Atypical subtrochanteric femur fracture in patient with metastatic breast cancer treated with zoledronic acid Yong-Seok Kim, Woo-Chan Park pp.261-264

참고문헌 (24건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Induction chemotherapy followed by breast conservation for locally advanced carcinoma of the breast. 네이버 미소장
2 Effects of primary chemotherapy in conservative treatment of breast cancer patients with operable tumors larger than 3 cm 네이버 미소장
3 van der Hage JA, van de Velde CJ, Julien JP, Tubiana-Hulin M, Vandervelden C, Duchateau L. Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902. J Clin Oncol 2001;19:4224-37. 미소장
4 Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. 네이버 미소장
5 Neoadjuvant chemotherapy in the combined modality approach of locally advanced nonmetastatic breast cancer. 네이버 미소장
6 Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy. 네이버 미소장
7 Molecular portraits of human breast tumours. 네이버 미소장
8 Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy 네이버 미소장
9 Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy 네이버 미소장
10 The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes 네이버 미소장
11 Immunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy 네이버 미소장
12 Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, et al. Strategies for subtypes: dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 2011;22: 1736-47. 미소장
13 Greene FL, American Joint Committee on Cancer. AJCC Cancer Staging Manual. 6th ed. New York: Springer-Verlag; 2002. 미소장
14 Prognostic and Predictive Factors in Breast Cancer by Immunohistochernical Analysis 네이버 미소장
15 Gene expression predictors in breast cancer: Current status, limitations and perspectives 네이버 미소장
16 Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. 네이버 미소장
17 Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. 네이버 미소장
18 Ring AE, Smith IE, Ashley S, Fulford LG, Lakhani SR. Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. Br J Cancer 2004;91:2012-7. 미소장
19 Phase 2 randomized trial of primary endocrine therapy versus chemotherapy in postmenopausal patients with estrogen receptor‐positive breast cancer 네이버 미소장
20 Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. 네이버 미소장
21 Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet 2010;375:377-84. 미소장
22 Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study. 네이버 미소장
23 Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. 네이버 미소장
24 Dawson SJ, Provenzano E, Caldas C. Triple negative breast cancers: clinical and prognostic implications. Eur J Cancer 2009;45 Suppl 1:27-40. 미소장

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