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Purpose: Estrogen receptor (ER) is the key therapeutic target in breast cancer. ERβhas recently been identified to be distinct from ERα. In contrast to ERα, the functions of ERβin breast cancer are still unclear. We sought to determine whether the expression of ERβcan be used as a predictive marker for endocrine therapy for patients with ERα-negative breast cancer. Methods: Formalin-fixed, paraffinembedded tumor specimens from 52 patients with ER-/PR+invasive breast cancer were immunostained for their ERβ expression. These patients were treated with adjuvant tamoxifen. The results were correlated with various clinicopathological variables and the follow-up data. The expressions of p53 and HER-2/neu were also analyzed and correlated with the ERβstatus. Results: An ERβexpression was observed in 53.8% (28/52) of the breast cancer samples. There was no correlation between the ERβexpression and the other clinicopathologic factors (age, tumor size, histologic type, nodal status, histological grade, stage, therapeutic modality, progesterone receptor (PR) expression, p53 expression and HER-2/neu expression). Recurrence was present in 7.7% (2/26) of the patients whose tumors had an ERβexpression, as compared to the presence of recurrence in 36.4% (8/22) of the patients whose tumors had no ERβexpression (p<0.05). The patients with ERβnegative-tumors revealed lower disease free survival rate than those with ERβpositive-tumors (p<0.05). Of the 52 patients, 10(19.2%) were p53 positive, and 11 (21.2%) were HER-2/neu positive. No significant correlations were observed between ERβand p53 or HER-2/neu. Conclusion: These results suggest that ERβmight be a predictive marker of a response to endocrine therapy in patients with ER-/PR+ invasive breast cancer, although this needs to be confirmed by additional studies.

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기사명 저자명 페이지 원문 목차
MUC1 from the mucin family as potential tools in breast cancer immunotherapy Heung Kyu Park, U Hyoung Seo pp.125-133

Reactive oxygen species generated by 17β-estradiol play a role in the up-regulation of GPX4 protein in MCF-7 breast cancer cell Sang-Han Lee, Hee Jeong Kim, Hyo Jin Kang, Yoon-Jin Lee, Hae-Seon Nam, Insoo Bae pp.134-141

Additional breast ultrasound examinations in clustered calcifications : for improving diagnostic performance Hee Young Kim, Bo Kyoung Seo, Hee-Young Kim, Ann Yie, Kyu Ran Cho, Hae Young Seol, Sang Hoon Cha, Baek Hyun Kim, Gil Soo Son, Jung Won Bae pp.142-150

The use of absorbable surgical mesh after partial mastectomy for improving the cosmetic outcome Hyung Ook Kim, Sang Il Hwang, Cha Kyong Yom, Yong Lai Park, Won Gil Bae pp.151-155

에스트로겐 수용체 알파 음성 및 프로게스테론 수용체 양성인 유방암 환자에서 에스트로겐 수용체 베타의 발현이 호르몬 치료에 미치는 영향 박민호, 유희선, 노혜원, 조진성, 윤정한, 제갈영종, 김조헌, 이지신, 박창수 pp.156-162

유방암 환자에서 ^18^F-FDG PET/CT와 초음파검사를 이용한 수술 전 액와 림프절 전이 평가 김용훈, 이진선, 이철주, 김제룡, 장일성 pp.163-169

유방암 환자에서 수술 중 감시림프절 동결절편검사의 유용성과 한계 성우정, 김애리, 강수환, 이수정, 황태윤, 배영경 pp.170-178

유방암 환자의 액와부 수술 중 상지에서 배액되는 림프 경로의 보존 최정은, 전영산, 강수환, 이수정 pp.179-185

유방보존수술 후 광배근 피판을 이용한 즉시 재건술의 안정성 및 미용적 효과 김상원, 이석재, 이혁진, 이진용 pp.186-192

조기 유방암의 치료에 있어 내시경 하 유방 보존술 후 재건을 위한 Polyglactin 910 Mesh를 이용한 새로운 방법에 대한 초기 결과 이재훈, 홍영익, 정진호, 이종인, 이종훈, 문현종, 박재균, 신혁재 pp.193-198

유방암 환자의 우울과 대처 박병우, 황숙연 pp.199-209

'유방수술에 있어서 외과용 메시 사용현황'에 대한 국내 설문조사 결과 김구상, 박만영, 김우재, 나국영, 정용식, 최영진, 박용래, 오세정, 신혁재 pp.210-214

비소세포폐암의 동측 유방전이 : 증례보고 김준호, 염차경, 김영은, 박용래, 배원길, 오태윤, 손진희 pp.215-218

Malignant adenomyoepithelioma of the breast presenting as a large mass that grew slowly without metastasis So-young Choi, Joong Suck Kim, Sei Joong Kim, Yun Jeong Kim, Lucia Kim, Young Up Cho pp.219-222

Malignant peripheral nerve sheath tumor of the breast in a patient without neurofibromatosis : a case report Jeong Min Yi, Eun Jeong Moon, Se Jeong Oh, Ahni Lee, Young Jin Suh, Jong Min Baek, Seung Hye Choi, Sang Seol Jung pp.223-226

Commentary on "The Number of Removed Lymph Nodes for an Acceptable False Negative Rate in Sentinel Node Biopsy for Breast Cancer" Seok Jin Nam, Se Kyung Lee pp.227-228

참고문헌 (29건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. 네이버 미소장
2 Sequence and Expression of Human Estrogen Receptor Complementary DNA 네이버 미소장
3 Tamoxifen in the treatment of breast cancer. 네이버 미소장
4 Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. 네이버 미소장
5 Cloning of a novel receptor expressed in rat prostate and ovary. 네이버 미소장
6 Increased expression of estrogen receptor beta in chemically transformed human breast epithelial cells. 네이버 미소장
7 Speirs V, Parkes AT, Kerin MJ, Walton DS, Carleton PJ, Fox JN, et al. Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer? Cancer Res 1999;59:525-8. 미소장
8 Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. 네이버 미소장
9 Estrogen receptor beta expression in invasive breast cancer 네이버 미소장
10 Clinical value of the wild-type estrogen receptor beta expression in breast cancer. 네이버 미소장
11 Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia. 네이버 미소장
12 The favourable prognostic value of oestrogen receptor beta immunohistochemical expression in breast cancer. 네이버 미소장
13 Estrogen receptor beta in breast cancer: associations between ERbeta, hormonal receptors, and other prognostic biomarkers. 네이버 미소장
14 Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. 네이버 미소장
15 Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. 네이버 미소장
16 Inverse relationship between ER-beta and SRC-1 predicts outcome in endocrine-resistant breast cancer. 네이버 미소장
17 Oestrogen receptors alpha and beta show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer. 네이버 미소장
18 Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. 네이버 미소장
19 Expression of estrogen receptor beta, estrogen receptor alpha and cyclooxygenase II in advanced breast cancer 네이버 미소장
20 Comparison of estrogen receptor beta expression between breast cancer and normal mammary tissue and relationship with clinicopathological factors 소장
21 Recommendations for the reporting of breast carcinoma 네이버 미소장
22 Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al. AJCC Cancer staging manual. 6th ed. New York: Springer-Verlag; 2002. p.223. 미소장
23 Expression of vascular endothelial growth factor in adenocarcinomas of the uterine cervix and its relation to angiogenesis and p53 and c-erbB-2 protein expression. 네이버 미소장
24 Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. 네이버 미소장
25 Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue. 네이버 미소장
26 Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. 네이버 미소장
27 Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31 000 recurrences and 24 000 deaths among 75 000 women 네이버 미소장
28 Tamoxifen for early breast cancer: an overview of the randomised trials 네이버 미소장
29 Yu KD, Di GH, Wu J, Lu JS, Shen KW, Liu GY, et al. Breast cancer patients with estrogen receptor-negative/progesterone receptorpositive tumors: being younger and getting less benefit from adjuvant tamoxifen treatment. J Cancer Res Clin Oncol 2008;134:1347-54. 미소장

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