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한국학술지인용색인(NRF)
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The peel from seven types of citrus was extracted with 80% methanol, and their phenolic compound content, oxygen radical absorbance capacity (ORAC), inhibitory activities of nitric oxide (NO), and reactive oxygen species (ROS) production induced by LPS and t-BHP in LPS-activated RAW 264.7 cells were measured. Total phenolic content was high in Yungkyool, Cheonhyehyang, and Jinkyool (30.6, 30.2, and 28.2 mg GAE/g, respectively), while total flavonoid content was high in Yungkyool and Jinkyool (30.3 and 25.5 mg RE/g, respectively). ORAC was the highest at 1,076 mM TE/g in Yungkyool, followed by Cheonhyehyang (1,012), Jinkyool (984), and Hallabong (914). High inhibitory activity against NO production was shown in Cheonhyehyang, Yungkyool, and Jinkyool with IC50 values of 215.3, 259.2, and 328.9 μg/mL, respectively. LPS-induced ROS production was inhibited by 16.4% and 12.8% in Hallabong and Jinkyool, while t-BHP-induced ROS production was inhibited by 28.7%, 26.1%, and 26.6% in Jinkyool, Hallabong, and Cheonhyehyang, respectively. Correlation coefficients between total phenolic, total flavonoid content, and ORAC were 0.884 and 0.855. Inhibitory activity against NO production showed higher correlation with total phenolic content than total flavonoid content. It was concluded that citrus peels had potent antioxidant activities and could be used as natural antioxidants in the food and pharmaceutical industries.
권호기사
참고문헌 (35건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Free radicals and antioxidants in human health: current status and future prospects.  |
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| 2 | Endotoxemia and oxidative stress. |
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| 3 | Hydroperoxide-induced damage to alveolar macrophage function and membrane integrity: Alterations in intracellular-free Ca 2+ and membrane potential |
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| 5 | Free radicals and antioxidants in normal physiological functions and human disease. |
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| 6 | Liver response tests. IV. Application to short-term feeding studies with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) |
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| 7 | Correlation between Flavonoid Content and the NO Production Inhibitory Activity of Peel Extracts from Various Citrus Fruits(Miscellaneous) |
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| 8 | Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology |
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| 9 | Reactive Oxygen Species Scavenging Activity of Jeju Native Citrus Peel during Maturation | 소장 |
| 10 | Composition of Flavonoids and Antioxidative Activity from Juice of Jeju Native Citrus Fruits during Maturation | 소장 |
| 11 | Ahn MS., Kim HJ., Seo MS. (2007), A study on the antioxidative and antimicrobial activities of the Citrus unshiu peel extracts. Korean J Food Culture 22, 454-461. | 미소장 |
| 12 | Zhang Q., Zhang J., Shen J., Silva A., Dennis DA., Barrow CJ. (2006), A simple 96-well microplate method for estimation of total polyphenol content in seaweeds. J Appl Phycol 18, 445-450. | 미소장 |
| 13 | Estimation of Total Flavonoid Content in Propolis by Two Complementary Colorimetric Methods |
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| 14 | High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. |
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| 15 | Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. |
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| 16 | Improved detection of nitric oxide radical (NO.) production in an activated macrophage culture with a radical scavenger, carboxy PTIO and Griess reagent. |
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| 17 | Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7 |
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| 18 | Flavonoids: a review of probable mechanisms of action and potential applications. |
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| 19 | Park GH., Lee SH., Kim HY., Jeong HS., Kim EY., Yun YW., Nam SY., Lee BJ. (2011), Comparison in antioxidant effects of four citrus fruits. J Fd Hyg Safety 26, 355-360. | 미소장 |
| 20 | Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. |
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| 21 | Cardiovascular injury and repair in chronic obstructive pulmonary disease. |
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| 22 | Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. |
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| 23 | Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. |
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| 24 | Cai Y., Luo Q., Sun M., Corke H. (2004), Antioxidant activity and phenolic compounds of 112 traditional chinese medicinal plants associated with anticancer. Life Sci 74, 2157- 2184. | 미소장 |
| 25 | Antioxidant and antidiabetic activity of Dangyuja ( Citrus grandis Osbeck) extract treated with Aspergillus saitoi |
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| 26 | Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L.) peel |
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| 27 | Nitric oxide as a secretory product of mammalian cells. |
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| 28 | Cytokines and nitric oxide in islet inflammation and diabetes. |
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| 29 | Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. |
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| 30 | Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species. |
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| 31 | Tert-butyl hydroperoxide-induced radical production in rat liver mitochondria |
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| 32 | Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2). |
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| 33 | Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. |
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| 34 | Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. |
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| 35 | The influence of wine polyphenols on reactive oxygen and nitrogen species production by murine macrophages RAW 264.7. |
미소장 |
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