대표어
한국학술지인용색인(NRF)
권호기사보기
| 기사명 | 저자명 | 페이지 | 원문 | 기사목차 |
|---|
국회도서관 홈으로
정보검색
소장정보 검색
결과 내 검색
동의어 포함
초록보기
Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between childhood obesity and CVD risk, it would be worthwhile to evaluate whether previously identified lipid-related variants in adult subjects are associated with lipid variations in a childhood obesity study (n = 482). In an association analysis for 16genome-wide association study (GWAS)-based candidate loci, we confirmed significant associations of a genetic predisposition to lipoprotein concentrations in a childhood obesity study. Having two loci (rs10503669 at LPL and rs16940212 at LIPC) that showed the strongest association with blood levels of TG and HDL-C, we calculated a genetic risk score (GRS), representing the sum of the risk alleles. It has been observed that increasing GRS is significantly associated with decreased HDL-C (effect size, －1.13 ± 0.07) compared to single nucleotide polymorphism combinations without two risk variants. In addition, a positive correlation was observed between allelic dosage score and risk allele (rs10503669 at LPL) on high TG levels (effect size, 10.89 ± 0.84). These two loci yielded consistent associations in our previous meta-analysis. Taken together, our findings demonstrate that the genetic architecture of circulating lipid levels (TG and HDL-C) overlap to a large extent in childhood as well as in adulthood. Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.
권호기사
참고문헌 (35건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Addressing Cardiovascular Disease in Women: Focus on Dyslipidemia  |
미소장 |
| 2 | Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits |
미소장 |
| 3 | A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. |
미소장 |
| 4 | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. |
미소장 |
| 5 | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. |
미소장 |
| 6 | Common variants at 30 loci contribute to polygenic dyslipidemia. |
미소장 |
| 7 | Newly identified loci that influence lipid concentrations and risk of coronary artery disease. |
미소장 |
| 8 | Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels |
미소장 |
| 9 | Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, et al. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet 2011;43:990-995. | 미소장 |
| 10 | A genome-wide association meta-analysis identifies new childhood obesity loci. |
미소장 |
| 11 | The mystery of missing heritability: Genetic interactions create phantom heritability |
미소장 |
| 12 | Building genetic scores to predict risk of complex diseases in humans: is it possible? |
미소장 |
| 13 | Genetic Risk Score and Risk of Myocardial Infarction in Hispanics |
미소장 |
| 14 | Literature-Based Genetic Risk Scores for Coronary Heart Disease: The Cardiovascular Registry Maastricht (CAREMA) Prospective Cohort Study |
미소장 |
| 15 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. |
미소장 |
| 16 | A genotype calling algorithm for affymetrix SNP arrays. |
미소장 |
| 17 | OpenADAM: an open source genome-wide association data management system for Affymetrix SNP arrays. |
미소장 |
| 18 | Use of the Friedewald formula to estimate LDL-cholesterol in patients with chronic renal failure on dialysis. |
미소장 |
| 19 | Analysis of quantitative lipid traits in the genetics of NIDDM (GENNID) study. |
미소장 |
| 20 | Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q. |
미소장 |
| 21 | Childhood obesity and adult cardiovascular disease risk: a systematic review. |
미소장 |
| 22 | Hypertension, sleep apnea, and atherosclerosis. |
미소장 |
| 23 | Gaw A. HDL-C and triglyceride levels: relationship to coronary heart disease and treatment with statins. Cardiovasc Drugs Ther 2003;17:53-62. | 미소장 |
| 24 | Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, et al. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med 2009;150:541-550. | 미소장 |
| 25 | Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. |
미소장 |
| 26 | Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish obese subjects study. |
미소장 |
| 27 | Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, et al. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet 2011;7:e1001300. | 미소장 |
| 28 | Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease |
미소장 |
| 29 | Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes |
미소장 |
| 30 | A genome-wide investigation of SNPs and CNVs in schizophrenia. |
미소장 |
| 31 | A genome‐wide association study for quantitative traits in schizophrenia in China |
미소장 |
| 32 | Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia |
미소장 |
| 33 | Association between schizophrenia and single nucleotide polymorphisms in lipoprotein lipase gene in a Han Chinese population. |
미소장 |
| 34 | Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene ( |
미소장 |
| 35 | Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, et al. Essential role of ELOVL4 in very long chain fatty acid synthesis and retinal function. J Biol Chem 2011 Dec 24 [Epub]. http://dx.doi.org/10.1074/jbc.M111.256073. | 미소장 |
MARC 보기
오류 데이터 정정요청
*표시는 필수 입력사항입니다.
알림톡 발송
| 전화번호 |
|---|
개인정보 수정 바로가기
연속간행물 권호 선택
우편복사 안내
- ◾ 도서관을 방문하지 못할 경우 인터넷, 팩스 등으로 자료 복사를 신청하고, 복사물을 우편·팩스 등으로 제공받는 서비스
- ◾ 대상자료: 일반도서, 연속간행물 및 학위논문
- ※ 고서, 고잡지, 훼손될 우려가 있는 자료, 마이크로폼 자료 및 신문 등 제외
- ◾ 신청 책수: 1인 5책 이하(1일 기준)
- ◾ 신청 절차: 자료 검색 → 우편복사 목록담기 → 복사 범위 입력 → 우편복사 주문서 입력 → 접수 및 확인
- ※ 저작권법에 의거하여 부분 복사(전체 페이지 수의 1/3 범위 이내)만 가능
- ◾ 복사 범위 입력 예시: (연속 페이지) 1-30, (부분 페이지) 25, 30-40
| 번호 | 발행일자 | 권호명 | 제본정보 | 자료실 | 원문 | 신청 페이지 |
|---|
도서위치안내(서울관)
도서위치안내: / 서가번호:
0
확인
우편복사 목록담기를 완료하였습니다.
내서재에 담기
새로운 서재
*표시는 필수 입력사항입니다.
저장
저장 되었습니다.