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Thrombophlebitis of the portal venous system (PVS) with superimposed bacterial infection (septic pylephlebitis) is an extremely rare complication of Crohn’s disease (CD), and therefore diagnosis of septic pylephlebitis is difficult without high clinical suspicion. A 16-year old male patient who was diagnosed with CD 3 months earlier was admitted with recurrent fever and abdominal pain. CD activity had been well controlled with conventional medical treatment during a follow-up period. Abdominal contrast-enhanced computed tomography showed massive thrombosis in the PVS without evidence of intra-abdominal infection, and blood cultures were positive for Streptococcus viridians. There was no evidence of deep vein thrombosis or pulmonary thromboembolism, and all laboratory tests for thrombophilia were normal. Based on these findings, the patient was diagnosed with septic pylephlebitis complicated with CD, and was successfully treated with intravenous antibiotic therapy combined with anticoagulation. This case suggests that early comprehensive evaluation is crucial for immediate diagnosis and proper treatment of septic pylephlebitis in patients with CD who present with fever and abdominal pain of unknown origin, even with stable disease activity and absence of other intra-abdominal infections.

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참고문헌 (19건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? 네이버 미소장
2 Septic thrombophlebitis of the superior mesenteric vein and multiple liver abscesses in a patient with Crohn's disease at onset. 네이버 미소장
3 Sherigar R, Amir KA, Bobba RK, Arsura EL, Srinivas N. Abdominal pain secondary to pylephlebitis: an uncommon disease of the portal venous system, treated with local thrombolytic therapy. Dig Dis Sci 2005;50:983-987. 미소장
4 Regional enteritis complicated by pylephlebitis and multiple liver abscesses 네이버 미소장
5 Pylephlebitis: a case report and review of outcome in the antibiotic era. 네이버 미소장
6 Portal Pyaemia as a Presenting Feature of Paediatric Crohn Disease 네이버 미소장
7 Ng SS, Yiu RY, Lee JF, Li JC, Leung KL. Portal venous gas and thrombosis in a Chinese patient with fulminant Crohn's colitis: a case report with literature review. World J Gastroenterol 2006;12:5582-5586. 미소장
8 Crohn’s disease presenting as septic thrombophlebitis of the portal vein (pylephlebitis): case report and review of the literature 네이버 미소장
9 Portal-mesenteric pylephlebitis with hepatic abscesses in a patient with Crohn's disease treated successfully with anticoagulation and antibiotics. 네이버 미소장
10 Enterovenous fistula: unusual complication of Crohn disease. 네이버 미소장
11 Suppurative pylephlebitis. 네이버 미소장
12 Mesenteric arterial thrombosis as a complication of Crohn's disease. 네이버 미소장
13 Freeman HJ. Venous thromboembolism with inflammatory bowel disease. World J Gastroenterol 2008;14:991-993. 미소장
14 Murthy SK, Nguyen GC. Venous thromboembolism in inflammatory bowel disease: an epidemiological review. Am J Gastroenterol 2011;106:713-718. 미소장
15 Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study 네이버 미소장
16 Intra-abdominal venous and arterial thromboembolism in inflammatory bowel disease. 네이버 미소장
17 Guidelines for the management of inflammatory bowel disease in adults. 네이버 미소장
18 Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 네이버 미소장
19 Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism 네이버 미소장