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한국학술지인용색인(NRF)
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Objectives : The root of Codonopsis pilosula (Fr.) Nannf. (Codonopsis Pilosulae Radix) has been traditionally used as a oriental medicine with an anti-thrombotic, antidiabetic, anticancer, and anti-gastric ulcer effects and immunological adjuvant. In this study, we investigated the effect of 70% ethanol extract of Codonopsis Pilosulae Radix (CPR-E) on ovalbumin (OVA)-induced allergic responses in mice.
Methods : Mice were sensitized (1, 8, and 15 days) with OVA and airway challenged(22, 24, 26, 28, and 30 days) to induced allergic responses. CPR-E extract at doses of 50 and 100 ㎎/㎏/body weight was orally administered from days 21 to 30 consecutively. The levels of allergic mediators such as histamine, OVA-specific immunoglobulin (Ig) E, and Th1/Th2 cytokines such as IFN-γ and IL-4 were measured in the sera of mice by ELISA. The histological change of lung tissue was observed by hematoxylin and eosin (H&E) staining.
Results : CPR-E extract significantly decreased the serum levels of histamine, OVA-specific IgE, and IL-4 compared with those of OVA control group, but significantly increased the serum level of IFN-γ. Based on H&E staining, CPR-E extract inhibited the infiltration of inflammatory cells into lung tissues with histological changes.
Conclusions : These results indicate that CPR-E extract has anti-inflammatory and anti-allergic responses through regulating the cytokine balance, suggesting that the extract may be useful for the treatment of allergic inflammatory diseases such as bronchial asthma and allergic rhinitis.권호기사
참고문헌 (29건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Dose range finding study of KOB03, a new polyherbal medicine for the treatment of allergic rhinitis, by oral administration for four weeks in Sprague-Dawley rats | 소장 |
| 2 | Review : Clinical application and efficacy of herbal medicines by modulating cytokines in atopic dermatitis-induced animal model | 소장 |
| 3 | Korean Journal of Asthma, Allergy and Clinical Immunology. Asthma and Allergy disease. Seoul : Koonja publisher. 2002 ; 66 : 431-3. | 미소장 |
| 4 | seoul National University College of Medicine. Immunology. Seoul : Seoul National University publisher. 1987 : 188-97. | 미소장 |
| 5 | Role of Mast Cells in Allergic Inflammation and Innate Immunity. | 소장 |
| 6 | Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α  |
미소장 |
| 7 | Regulation of mast-cell and basophil function and survival by IgE |
미소장 |
| 8 | Choi KJ. Effect of Saururus chinensis (Lour.) Baill Aquacupuncture on Allergy in Mice. Dongeui university. 2004 : 1-23. | 미소장 |
| 9 | Hong WS. JungkyoHuangjenaegyeongsomun. seoul : Dongyang medicine Institute publisher. 1981 : 24, 39, 119. | 미소장 |
| 10 | The whole country a college of Orental medicine The joint textbook publish commission compilatioin. herbology. seoul : yonglimsa. 2006. 578-9. | 미소장 |
| 11 | Evaluation of In-vitro Anticoagulation Activity of 33 Different Medicinal Herbs | 소장 |
| 12 | Dangshen (Codonopsis pilosula) activates IGF-I and FGF-2 pathways to induce proliferation and migration effects in RSC96 Schwann cells. |
미소장 |
| 13 | Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice |
미소장 |
| 14 | Immunological adjuvant effect of a water-soluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice. |
미소장 |
| 15 | Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats |
미소장 |
| 16 | The contribution of side chains to antitumor activity of a polysaccharide from Codonopsis pilosula |
미소장 |
| 17 | CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. |
미소장 |
| 18 | Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitization |
미소장 |
| 19 | Tryptase inhibition blocks airway inflammation in a mouse asthma model. |
미소장 |
| 20 | Immunological adjuvant effect of a water-soluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice. |
미소장 |
| 21 | Gagam-Gongjin-dan Extract Attenuates Immune Responses to Ovalbumin in Balb/c Mice |
미소장 |
| 22 | Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitization |
미소장 |
| 23 | Preventive effect of a traditional herbal medicine, Hochu-ekki-to, on immunosuppression induced by surgical stress |
미소장 |
| 24 | An aqueous Chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo |
미소장 |
| 25 | Pattern analysis of human cutaneous mast cell populations by total body surface mapping |
미소장 |
| 26 | Schwartz LB, Huff TF. Biology of mast cells. In : Middleton E, editor. Allergy : Principles and practice. 5th ed. Mosby St. Louis. 1998 : 261-76. | 미소장 |
| 27 | The Role of Mast Cells in Innate and Adaptive Immunity | 소장 |
| 28 | Jung HY. Molecular bioloy of cytokines. worldscience publishing company. 2002 : 117-24. | 미소장 |
| 29 | Pathophysiology of Asthma. |
미소장 |
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