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Bioreactor systems that use a new aeration concept have recently been introduced. Bioreactors can assist in the development of new tissues in vitro by providing appropriate stimuli to the cell cultures. The design of bioreactors

for tissue engineering is very complex and is often tailored to individual cell- engineered-tissue products. Critical elements in bioreactor systems based on cells and scaffolds include cell seeding, the nutrient and gas supply to

cells, and mechanical stimuli. Flow perfusion systems have been shown to enhance cell growth, differentiation, and tissue formation as well as provide for the appropriate and necessary mass transfer of nutrients, gases, metabolites, and regulatory molecules. The beneficial effects of fluid flow induced convective transport and shear stress have been exploited in various types of bioreactors because fluid flow-through cell and tissue engineered constructs increase nutrient transport. These systems are called flow-perfusion bioreactors. In this paper, we review the characteristics of bioreactor systems used for cell culture in tissue engineering, and provide a schematic design for a novel bioreactor system that incorporates the elements we deem critical for such systems.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
케라틴/PLGA 지지체가 골수간엽줄기세포의 신경분화에 미치는 영향 오아영, 김순희, 김초민, 정수현, 홍현혜, 이상진, Mark van Dyke, 이동원, 이종문, 강길선, 전나리, James J Yoo pp.112-118

회전근개파열에 대한 관절경하 봉합술후 자가골수혈장 주입법의 유용성 노경환, 문영래, 유재원, 송창훈, 조승환 pp.28-33

The Combination Treatment of Angiotensin Ⅱ Receptor Antagonist and Aldosterone Receptor Antagonist Modulates Matrix Metalloproteinase-2 Expression and Activity in Infarcted Myocardium 고윤석, 정해억, 백상홍, 김범준, 승기배, 김재형, 최규보, 송병욱 pp.34-42

약물전달용 하이드로겔 나노입자 이상효, 강길선, 이봉, 박영환, 전흥재, 김재호, 이해방, 손진수, 오재민, 고재훈, 김문석 pp.57-62

히알루론산을 함유한 PLGA 지지체와 섬유륜세포를 이용한 디스크 재생 최진희, 김순희, 홍희경, 김수진, 이선경, 김온유, 박종학, 이종문, 강길선 pp.83-88

인간협지방대유래 줄기세포의 골분화에 대한 심바스타틴의 효과 김창현, 최기수, 이일규, 박재억, 표성운 pp.2-8

Osteogenic Effects on Athymic Rat Calvarial Defects by Human Originated Cortical Bone 서석진, 허재원, 채지화, 전성현, 김진, 강낙헌, 이광원, 강계원 pp.9-14

Effects of 4 Different Alloplastic Materials on Bone Regeneration in Rabbit Calvarial Defects 김선종, 임진원, 류재준, 안진수, 한인호, 신상완 pp.63-68

인체 탯줄유래 중간엽줄기세포의 모발 유도능 평가 유보영, 신연호, 윤희훈, 김영진, 서영권, 송계용, 박정극 pp.15-22

Osteogenecity and Biomechanical Properties of Autologous Osteoblast Cells Mixed with Fibrin 홍승환, 박원종, 양석조, 김기원, 김석중, 창청호, 이윤경, 서동삼, 서경환 pp.52-56

사람손발톱과 피부를 통한 약물 투과향상 안식일, 엄신, 김용기, 김윤태, 박종학, 이준희, 김대성, 김원, 이종문, 강길선, 전나리 pp.23-27

Different Effects of Leukotriene B4 Receptors on the Proliferation of Mesenchymal Stem Cells 박승연, 염정은, 이성범, 전흥재, 채규태 pp.69-76

손발톱 팽윤을 통한 약물투과의 향상 안식일, 엄신, 김용기, 김윤태, 정수현, 이준희, 박종학, 김원, 양재찬, 강길선, 김대성, 이종문 pp.104-111

염산 랄록시펜 고체분산체의 특성 및 용출율 개선 박종학, 김세호, 안식일, 이준희, 김윤태, 김대성, 김원, 이종문, 강길선, 최진희, 이동원 pp.77-82

Targeting Cancer Stem Cells 최상운, 한선영 pp.100-103

Establishment of Techniques for Primary Isolation, Characterization, and Long-Term Maintenance of Porcine Endothelial Cells 양지혜, 남현, 이동섭, 이정열, 이진, 이슬비, 김동은, 조재진 pp.89-94

The Reducing Toxicity Action of Polyvinylpyrrolidone(PVP) in Vitrification Solutions and Its Effect on Subsequent Development of Mouse Embryos 김치구, 이진, 조재진, 용환율 pp.95-99

Controlled Formulation for Epinephrine Delivery from Hydrogel Microspheres Ta Tuan Minh, 임정옥, 백운이 pp.119-125

The Effects of Vascular Endothelial Growth Factor in Differentiation of Bone Marrow Stromal Cell into Endothelial Cell 한성엽, 김종욱, 전상연, 김흥중, 김병옥, 박주철, 송창훈, 장현선, 박주철 pp.126-130

Survival and Migration of Intracerebrally Transplanted human Adipose Tissue-Stromal Cells after Transient Global Cerebral Ischemia in Rats 정시경, 이일우, 이운정, 정연희, 전흥재, 최승필, 박규남 pp.131-141

Early Osteoblast-like Cell Spreading on Hydrophilic Phosphate Ion-incorporated Titanium Oxide Surface 장제희, 김연정, 박진우, 서조영 pp.142-147

PVP의 분자량에 따른 시부트라민 고체분산체의 방출거동에 대한 영향 이준희, 양재찬, 이영현, 김원, 박종학, 안식일, 김윤태, 이종문, 강길선, 김대성, 이동원 pp.148-154

이종 탈회골기질과 피브린젤혼합체가 신생골형성에 미치는 영향 이광일, 이근수, 김일환, 장주웅, 김대현, 문성환, 전흥재, 김휘율 pp.170-178

조직공학적 연골재생을 위한 In Vivo 환경에서의 케라틴/PLGA 지지체의 효과 정수현, 김순희, 양재찬, 홍현혜, 김혜린, 김원, 손영숙, 이상진, Mark van Dyke, James J Yoo, 이종문, 강길선 pp.192-198

Mechanical Stimulation of Mesenchymal Stem Cells for Tissue Engineering 김장호, 조종수, 정연훈, 임기택, 선우훈, 백수정, 전성후, 박주영, 정필훈, 정종훈, 손현목 pp.199-206

Novel Perfusion Bioreactor Systems for Tissue Engineering 임기택, 조종수, 정연훈, 김장호, 선우훈, 백수정, 전성후, 박주영, 정필훈, 정종훈, 손현목 pp.207-218

경피약물제제의 최적화 김윤태, 이준희, 이은용, 엄신, 김용기, 김세호, 박현진, 이영현, 성경열, 강길선, 이한구, 안식일, 김원, 김대성, 박종학 pp.219-228

Newborn Calf Serum Retards Loss of the Chondrocytic Phenotype during In Vitro Cell Expansion 이정선, 이진연, 이은경, 손영숙 pp.229-235

용매 추출/증발을 통한 미립구제조 오재민, 이상효, 김병수, 이해방, 강길선, 김문석, 손진수, 이성구 pp.236-242

중간엽 줄기세포의 연골세포로의 분화능에 (-)-에피갈로카테킨 갈레이트가 미치는 영향 송지혜, 박부영, 김종일, 최성훈, 김동일 pp.243-249

Influence of Static Magnetic Field Stimulation on Cells for Tissue Engineering 임기택, 조종수, 정연훈, 김장호, 선우훈, 전성후, 박주영, 정필훈, 정종훈, 손현목 pp.250-258

자가혈액에서 농축한 골유도성장인자의 임상응용과 개발의 최근동향 이덕원, 지유진 pp.259-264

가토 두개골 결손부에서 합성골이식재와 혼합사용된 혈소판풍부혈장(PRP)과 혈소판풍부피브린(PRF) 적용에 따른 골형성 효과비교 이덕원, 남광호, 지유진, 이백수 pp.265-272

흰쥐 두개골결손을 이용한 황산칼슘 및 탈회골 복합충진재의 골재생 촉진효과 연구 이은정, 전성현, 채지화, 허재원, 강계원, 김진, 이광원, 김경표 pp.287-293

흰쥐에서 외부압력에 따른 엉치부위 피부의 혈류 및 조직학적 변화 이호, 조강희 pp.294-299

Regeneration of Facial Nerve using Mesenchymal Stem Cells in Facial Nerve Palsy Animal Model 권성근, 송재준, 조창건, 박석원 pp.300-306

In Vivo Chondrogenesis of Adipose Tissue-Derived Stem Cells in Alginate Gel 김석권, 이근철, 권용석, 이장호 pp.155-164

Comparative Phenotypic Analysis of Mesenchymal Stem Cells Derived from Bone Marrow, Skin, Adipose Tissue and Umbilical Cord 이정미, 권혁찬, 박현숙, 이선래 pp.179-185

심혈관질환 치료를 위한 줄기세포의 최적화 전략 김용숙, 박인규, 권진숙, 정명호, 안영근, 김명곤 pp.186-191

Limitation of Q Dot as an In Vivo Cell Tracer 김진훈, 김호중, 서수원, 공원호 pp.307-312

인간 지방조직유래 줄기세포의 PLCL/피브린 복합지지체에서 연골세포로의 분화 김상희, 정영미, 김철근, 김수현, 김상헌, 이종원, 김영하 pp.313-319

란각으로 제조한 수산화아파타이트 및 β-트리칼슘포스페이트다공체를 이용한 골형성 능력 비교 김선희, 이은정, 오남식, 이상진, 이명현 pp.320-326

Intradermal Delivery of Adipose Tissue-Derived Stem Cells Accelerates Wound Healing in Radiation-Induced Skin Injury 김형인, 설동림, 서지연, 윤영철, 정순호, 안기정, 장원희, 양영일, 최민영, 강미선 pp.327-335

Comparison of Osteogenic Differentiation from Adipose-Derived Stem Cells, Mesenchymal Stem Cells, and Pulp Cells on PLGA/Hydroxyapatite Nanofiber 윤영필, 허동녕, 배민수, 신동렬, 임순빈, 박상진, 권일근, 김성은, 이정복, 최경규 pp.336-345

Effect of E Coli Expressed Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) on Stem Cells for Periodontal Tissue Regeneration : A Preliminary Study 엄유정, 조구성, 김창성 pp.346-352

AFM Imaging Analysis of Alopecia Areata by Edge Detection 이기자, 어윤혜, 최삼진, 정기헌, 류박린, 심우영, 오범석, 박헌국, 정기헌, 김휘준, 이무형 pp.360-364

Dedifferentiated Chondrocyte Culture using Alginate Microbead Prepared from Microfluidic Technique 박귀덕, 황지영, 김충, 전흥재, 한동근, 강지윤 pp.353-359

Biochemical and Histological Evaluations of Articular Cartilages Preserved in Cold Storage Solution Containing Green Tea Catechin, EGCG 한동욱, 현성휴, 배정윤 pp.380-387

줄기세포를 이용한 조직공학적 치아재생 동향 전소영, 최영애, 김재영, 조제열, 신홍인, 이효정, 박의균 pp.388-400

Topographic Control of Cell Response to Synthetic Materials 임정열 pp.365-370

Self-Assembled Fibroblasts-Populated Dermal Equivalent Based on Fibrin Matrix 서지연, 김형인, 설동림, 최민영, 윤영철, 정순호, 장원희, 양영일 pp.401-407

Osteogenic Differentiation of Human Adipose-Derived Stem Cells(hADSCs) on a Dexamethasone Eluting Nanofiber Scaffolds 이정복, 김경준, 조동현, 권일근, 최귀원, Jun-Kyo Francis Suh, 박재홍, 최경규, 김규태, 최기운, 박용덕, 정성민, 윤인찬, 정종혁, 최용석 pp.371-379

참고문헌 (99건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 JA Asenjo, JC Merchuk, Bioreactor System Design, Marcel Dekker, 493-493(1) (1995). 미소장
2 Bioreactors and Bioprocessing for Tissue Engineering 네이버 미소장
3 The role of bioreactors in tissue engineering 네이버 미소장
4 M Shachar, S Cohen, Cardiac tissue engineering, ex vivo: design principles in biomaterials and bioreactors, Heart Fail, Rev 8, 271 (2003) 미소장
5 HW Blanch, DS Clark, Biochemical Engineering: Basic Concepts, 2nd edn, Marcel Dekker Inc, 502 (1996). 미소장
6 K Riet, J Tramper, Basic Bioreactor Design, Marcel Dekker Inc, 480 (1991). 미소장
7 ML Shuler, F Kargi, Bioprocessing Engineering: Basic Concepts NJ: Upper Saddle River, Prentice-Hall Inc (2002). 미소장
8 Y Martin, Patrick Vermette, Bioreactors for tissue mass culture: Design, characterization, and recent advances, Biomaterials, 26, 7481 (2005). 미소장
9 Design of a flow perfusion bioreactor system for bone tissue-engineering applications. 네이버 미소장
10 RP Schwwartz, TJ Goodwin, DA Wolf, Cell culture for three dimensional modelling in rotating wall vessels: An application of stimulated microgravity, J Tissue Culture Methods, 14, 51 (1992). 미소장
11 H Terai, D Hannouche, E Ochoa, et al, In vitro engineering of bone using a rotational oxygen - permeable bioreactor system, Materials Sci Eng:C, 20, 3 (2002). 미소장
12 RP Lanza, R Langer, J Vacant, Principles of Tissue Engineering, 2nd Ed, Academic Press, 427-446, 22, (2000). 미소장
13 Bioreactor Design for Tissue Engineering 네이버 미소장
14 JR Morgan, ML Yarmush, Tissue engineering methods and protocols, Humana Press, 630 (1999). 미소장
15 Tissue Engineering of Cartilage in Space 네이버 미소장
16 Tissue Engineering: Current Challenges and Expanding Opportunities 네이버 미소장
17 Artificial tissues in perfusion culture. 네이버 미소장
18 Perfusion cultures and modelling of oxygen uptake with three-dimensional chondrocyte pellets 네이버 미소장
19 Understanding factors that limit the productivity of suspension‐based perfusion cultures operated at high medium renewal rates 네이버 미소장
20 Potential of cell retention techniques for large‐scale high‐density perfusion culture of suspended mammalian cells 네이버 미소장
21 Long-term perfusion culture of hybridoma: a "grow or die" cell cycle system. 네이버 미소장
22 Effect of Oxygen Tension on Adult Articular Chondrocytes in Microcarrier Bioreactor Culture 네이버 미소장
23 Artificial tissues in perfusion culture. 네이버 미소장
24 M Shachar, S Cohen, Cardiac tissue engineering, ex-vivo: design principles in biomaterials and bioreactors, Heart Fail, Rev 8, 271 (2003). 미소장
25 S Nagel-Heyer, CH Goepfert, MM Morlock, et al, Relationship between gross morphological and biochemical data of tissue engineered cartilage - carrier - constructs, Biotechnol Lett, 27, 187 (2005). 미소장
26 A Sinclair, MHJ Ashley, Bioreactor System Design, Marcel Dekker, 553 (1995). 미소장
27 Experimental and theoretical considerations on oxygen supply for animal cell growth in fixed-bed reactors 네이버 미소장
28 The design of scaffolds for use in tissue engineering. Part I. Traditional factors. 네이버 미소장
29 Functional tissue engineering: the role of biomechanics. 네이버 미소장
30 Excitability and Isometric Contractile Properties of Mammalian Skeletal Muscle Constructs Engineered in vitro 네이버 미소장
31 Bone tissue engineering: state of the art and future trends. 네이버 미소장
32 Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2 네이버 미소장
33 Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow. 네이버 미소장
34 Functional tissue engineering: the role of biomechanics. 네이버 미소장
35 EM Darling, KA Athanasiou, Articular cartilage bioprocesses and bioreactors, Tissue Eng, 9, 9 (2003). 미소장
36 Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures 네이버 미소장
37 Fluid Flow Increases Mineralized Matrix Deposition in 3D Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner 네이버 미소장
38 ST Nagel-Heyer, Engineering aspects for generation of three - dimensional cartilage-carrier-constructs, Norderstedt (2004). 미소장
39 S Nagel-Heyer, CH Goepfert, P Adamietz, et al, Flow chamber bioreactor culture for generation of three - dimensional cartilage carrier constructs, Bioproc Biosyst Eng, 27, 273 (2005). 미소장
40 From lab bench to market: critical issues in tissue engineering. 네이버 미소장
41 A compliant tubular device to study the influences of wall strain and fluid shear stress on cells of the vascular wall. 네이버 미소장
42 Mechanobiology of engineered cartilage cultured under a quantified fluid-dynamic environment. 네이버 미소장
43 Streaming potentials: a sensitive index of enzymatic degradation in articular cartilage. 네이버 미소장
44 Oscillatory compressional behavior of articular cartilage and its associated electromechanical properties. 네이버 미소장
45 V Barron, E Lyons, C Stenson-Cox, et al, Bioreactors for cardiovascular cell and tissue growth: A review, Ann Biomed Eng, 31, 1017 (2003). 미소장
46 Flow-mediated endothelial mechanotransduction. 네이버 미소장
47 Techniques for mechanical stimulation of cells in vitro: a review. 네이버 미소장
48 MT Burrows, A method of furnishing a continuous supply of new medium to a tissue culture, In vitro Anat Rec, 6, 141 (1912). 미소장
49 A Carrel, A method for the physiological study of tissues, In vitro J Exper Med, 38, 407 (1923). 미소장
50 CA Lindbergh, Culture flask for the circulation of a large quantity of fluid medium, J Exper Med, 70, 231 (1939). 미소장
51 G Rose, Separable and multipurpose tissue culture chamber, Texas Rep Biol And Med, 12, 1074 (1954). 미소장
52 B Griffiths, Perfusion systems for cell cultivation Oxford, Bioprocess Techno, 10, 217 (1990). 미소장
53 A fiber-bed bioreactor for anchorage-dependent animal cell cultures: part I. Bioreactor design and operations. 네이버 미소장
54 A radial flow hollow fiber bioreactor for the large-scale culture of mammalian cells. 네이버 미소장
55 Immobilization can improve the stability of hybridoma antibody productivity in serum-free media. 네이버 미소장
56 BS Kim, J Nikolovski, J Banadio, et al, Cyclic mechanical strain regulates the development of engineered smooth muscle tissue, Nature Biotech, 17, 979 (1999). 미소장
57 Functional Arteries Grown In vitro 네이버 미소장
58 Vascular tissue engineering. 네이버 미소장
59 Organ printing: computer-aided jet-based 3D tissue engineering 네이버 미소장
60 N Hibino, Y Imai, T Shin-oka, et al, First successful clinical application of tissue engineered blood vessel, Kyobu Geka, 55, 368 (2002). 미소장
61 Successful clinical application of tissue-engineered graft for extracardiac Fontan operation 네이버 미소장
62 Functional Arteries Grown In vitro 네이버 미소장
63 D Seliktar, RA Black, RP Vito, et al, Dynamic mechanical conditioning of collagen-gel blood vessel constructs including remodeling in vitro, Ann Biomed Eng, 28, 351 (2000). 미소장
64 SP Hoerstrup, G Zund, R Sodian, et al, Tissue engineering of small caliber vascular grafts, Europe J Cardio-thoracic Surg, 20, 164 (2001). 미소장
65 Cardiovascular Tissue Engineering: A New Laminar Flow Chamber for In Vitro Improvement of Mechanical Tissue Properties 네이버 미소장
66 Proteoglycan synthesis by chondrocytes cultured under hydrostatic pressure and perfusion 네이버 미소장
67 Hydrostatic fluid pressure enhances matrix synthesis and accumulation by bovine chondrocytes in three‐dimensional culture 네이버 미소장
68 Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. 네이버 미소장
69 Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells 네이버 미소장
70 Electrophysiological Responses of Human Bone Cells to Mechanical Stimulation: Evidence for Specific Integrin Function in Mechanotransduction 네이버 미소장
71 Electromechanical potentials in cortical bone—I. A continuum approach 네이버 미소장
72 The production of nitric oxide and prostaglandin E 2 by primary bone cells is shear stress dependent 네이버 미소장
73 Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. 네이버 미소장
74 Effects of mixing intensity on tissue‐engineered cartilage 네이버 미소장
75 Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV). 네이버 미소장
76 Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds 네이버 미소장
77 Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh 네이버 미소장
78 Fluid Flow Increases Mineralized Matrix Deposition in 3D Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner 네이버 미소장
79 SH Cartmell, J Dobson, SB Verschueren, et al, Development of magnetic particle techniques for long term culture of bone cells with intermittent mechanical activation, IEEE Transactions on NanoBioscience, 12, 92 (2002). 미소장
80 B Porter, S Cartmell, R Guldberg, Design of a 3D Perfused Cell Culture System to Evaluate Bone. Regeneration Technologies, Transactions of ORS 25th-28th (2001). 미소장
81 Computational Fluid Dynamics Modeling of Steady‐State Momentum and Mass Transport in a Bioreactor for Cartilage Tissue Engineering 네이버 미소장
82 The influence of extracellular matrix on gene expression: is structure the message? 네이버 미소장
83 Extracellular matrix remodelling and cellular differentiation. 네이버 미소장
84 PF Davies, Spatial structural and genomic responces of endothelial cells to hemodynamic shear stress, Cardiovascular Pathology, 11, 25 (2002). 미소장
85 Tissue Engineering of Cartilage in Space 네이버 미소장
86 JE Bailey, DF Ollis, Biochemical engineering fundamentals, McGraw Hill Book Co, 745 (1986). 미소장
87 B Atkinson, F Mavituna, Biochemical Engineering and Biotechnology Handbook, Macmillan 581 (1983). 미소장
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89 K Bratch, The Development of a Bioartificial Liver Support System, The University of Birmingham (2000). 미소장
90 G Catapano, Mass transfer limitations to the performance of membrane bioartificial liver support devices, Intern J Artificial Organs, 19, 18 (1996). 미소장
91 LC Ellis, Free radicals in tissue culture Part IV Effects on cells in culture, Art Sci, 10, 1 (1991). 미소장
92 Mapping of oxygen tension and cell distribution in a hollow-fiber bioreactor using magnetic resonance imaging. 네이버 미소장
93 Functional assessment of tissue-engineered meniscal cartilage by magnetic resonance imaging and spectroscopy. 네이버 미소장
94 HJ Lee, BH Choi, BH Min, et al, Effects of low intensity ultrasound pretreatment on the chondrogenesis of rabbit mesenchymal stem cells, Tissue Eng Regen Med, 2(1), 50 (2005). 미소장
95 SR Park, BH Min, SH Park, et al, Application of mechanical stimulation for chondrogenesis, Tissue Eng Regen Med, 2(2), 77 (2005). 미소장
96 EK Lee, JS Lee, HS Park, et al, Stretch-stimulated cellular rearrangement and alteration of fibronectin matrix assembly, asmooth muscle actin, and CD44 expression in human mesenchymal stem cells, Tissue Eng Regen Med, 2(2), 94 (2005). 미소장
97 G Khang, SH Kim, MS Kim, et al, Recent and future directions of stem cells for the application of regenerative medicine, Tissue Eng Regen Med, 4(4), 441 (2007). 미소장
98 SH Kim, AY Oh, JH Choi, et al, Recent advances in manufacturing method of smart scaffold for regenerative medicine, Tissue Eng Regen Med, 5(3), 351 (2008). 미소장
99 Mesenchymal stem cell delivery routes and fate. 소장

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