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Traumatic brain injury (TBI) often leads to critical tissue damage and loss. Brain tissue engineering is a

promising technique for cellular replacement and neurological functional recovery in animals. However, useful biomaterial

scaffolds have not been found so far. In order to explore the feasibility of stem cell based brain tissue engineering,

it is first necessary to evaluate the biocompatibility of biomaterials with stem cells and brain tissues. In the

present study, two biomaterials, chondrocyte derived ECM (ECM) and silk fibroin (SF) scaffolds, were investigated

for their biocompatibility in vitro and in acute TBI. We found that when the ECM scaffold was cultured with rat mesenchymal

stem cells (rMSCs) or implanted directly into brain injury, had a good biocompatibility. rMSCs, seeded

on the ECM scaffold, were evenly distributed with a spindle shape and attached well, while on SF scaffold attached

with a round shape relatively weakly. In the TBI model, the SF scaffold resulted in a significant increase in the cavity

volume at 6 weeks postimplantation, but not the ECM scaffold. In addition, the ECM scaffold induced a lower

inflammatory response, with active microglia/macrophages at 1 week, than the SF scaffold and control. Interestingly,

both scaffolds reduced glial fibrillary acidic protein (GFAP) and neurocan expression in the cavity boundary

throughout the experimental periods. These results indicate that the scaffolds tested inhibit the glial scar formation

in injured brain tissue. Moreover, there were no significant differences in the neurological outcome and weight body

gain, when compared with the brain injury alone. Taken together, these findings reveal that the ECM scaffold

showed good biocompatibility to the donor rMSCs and host brain tissue. Thus, the ECM scaffold seems to be beneficial

as a biomaterial for brain tissue engineering.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Development of a Perfusion Flow Bioreactor System for Culturing Human Alveolar Bone Marrow Stem Cells 임기택, 선우훈, 손현목, 백수정, 김장호, 홍성민, 박주영, 전성후, 정필훈, 정종훈, 손현목, 조종수, 정윤훈 pp.1410-1419

Chondrogenesis from Mesenchymal Stem Cells 김혜정, 임군일 pp.1343-1348

골조직공학에서의 생체재료 지지체의 적용과 혈관생성 김소영, 임군일 pp.1391-1400

Differentiation of GABAergic Neurons from Human Embryonic Stem Cells 이나연, 최정갑, 전익수, 송지환, 송지환 pp.1359-1365

Safety and Efficacy Assessment of Mesenchymal Stem Cells from Canine Adipose Tissue or Umbilical Cord Blood in a Canine Osteochondral Defect Model 최형준, 김종란, 이용근, 정윤혁, 이영순, 강경선, 민병현, 강병철, 권은아, 이재일, 제정환 pp.1381-1390

Efficient Cell Fusion Model of Stem Cells and Cancer Cells 안은경, 임선희, 허정훈, 김영호, 김자영 pp.1429-1434

Biomechanical Effects of Fluid Dynamics and Mass Transport on Cell Growth in Perfusion Bioreactors for Tissue Engineering 임기택, 김장호, 조종수, 선우훈, 백수정, 전성후, 박주영, 정윤훈, 정필훈, 정종훈, 손현목 pp.1327-1342

세포성장억제제를 처리하지 않은 지지세포로부터 인간배아줄기세포 배양법 황승태, 이석준, 강선웅, 이수홍 pp.1375-1380

A Comparative Biocompatibility Study of Chondrocyte-derived ECM and Silk Fibroin Scaffolds In Vitro and in Rat Acute Traumatic Brain Injury 김길환, 김문항, 임윤희, 박소라, 최병현, 박형준, 윤승환, 민병현, 박현선 pp.1420-1428

Proteomic Profiling of Undifferentiated hBM Mesenchymal Stem Cells under High Glucose Conditions 김미령, 최애진, 김찬화 pp.1366-1374

인간배아줄기세포와 기형종 : 전분화능의 증거와 조직공학 리서치 툴로서의 가치 이유진, 김한수 pp.1349-1358

Comparison of Osteogenic Differentiation of Bone Marrow Stromal Cells on Zirconia and Titanium 우이형, 배아란, 배기창, 김형섭, 이희수 pp.1401-1409

Increased c-Fos Expression Contributes to Cell Survival Enhanced by Stromal Cell Derived Factor-1/CXCL12 in Synergy with other Cytokines in Mo7e Cells 이애란, 박정아, 김영은, 권형주, 이영희, 김영은 pp.1435-1442

참고문헌 (31건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 K Brännvall, K Bergman, U Wallenquist, S Svahn, T Bowden, J Hilborn, K Forsberg-Nilsson, Enhanced neuronal differentiation in a three-dimensional collagen-hyaluronan matrix, J Neurosci, 85(10), 2138 (2007). 미소장
2 Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. 네이버 미소장
3 COLLAGEN SCAFFOLDS POPULATED WITH HUMAN MARROW STROMAL CELLS REDUCE LESION VOLUME AND IMPROVE FUNCTIONAL OUTCOME AFTER TRAUMATIC BRAIN INJURY 네이버 미소장
4 Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends. 네이버 미소장
5 Scaffolds and biomaterials for tissue engineering: a review of clinical applications. 네이버 미소장
6 Spinal cord reconstruction using NeuroGel™ implants and functional recovery after chronic injury 네이버 미소장
7 Polymer hydrogels usable for nervous tissue repair 네이버 미소장
8 The repair of brain lesion by implantation of hyaluronic acid hydrogels modified with laminin 네이버 미소장
9 Silk-based biomaterials. 네이버 미소장
10 Physico-chemical properties of silk fibroin membrane as a biomaterial 네이버 미소장
11 Fine structure and oxygen permeability of silk fibroin membrane treated with methanol 네이버 미소장
12 In vitro evaluation of the inflammatory potential of the silk fibroin. 네이버 미소장
13 Growth of human cells on a non-woven silk fibroin net: a potential for use in tissue engineering. 네이버 미소장
14 Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds 네이버 미소장
15 Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells. 네이버 미소장
16 Biocompatibility evaluation of silk fibroin with peripheral nerve tissues and cells in vitro. 네이버 미소장
17 The extracellular matrix as a biologic scaffold material 네이버 미소장
18 Morphologic Assessment of Extracellular Matrix Scaffolds for Patch Tracheoplasty in a Canine Model 네이버 미소장
19 Regenerative Urinary Bladder Augmentation Using Small Intestinal Submucosa: Urodynamic and Histopathologic Assessment in Long-term Canine Bladder augmentations 네이버 미소장
20 KI Park, YD Teng, EY Snyder, The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue, Nat Biotechnol, 20(11), 1111 (2002). 미소장
21 CZ Jin, SR Park, BH Choi, BH Min, In vivo cartilage tissue engineering using a cell-derived extracellular matrix (ECM) scaffold, Art Org, 31(3), 183 (2007) 미소장
22 BH Min, HJ Kim, H Lim, SR Park, Characterization of subpopulated of human chondrocyte in monolayer culture and its reversibility in pellet culture, J Korea Orthop Res, 1, 23 (1998) 미소장
23 Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms. 네이버 미소장
24 Neural and marrow-derived stromal cell sphere transplantation in a rat model of traumatic brain injury. 네이버 미소장
25 The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. 네이버 미소장
26 E Shohami, M Novikov, R Bass, Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat, Brain Res, 674(1), 55 (1995). 미소장
27 Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells. 네이버 미소장
28 Inflammatory reaction dependence on implant localization in rat soft tissue models 네이버 미소장
29 RJ Gilbert, RJ McKeon, A Darr, A Calabro, VC Hascall, RV Bellamkonda, CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension, Mol. Cell. Neurosci, 29, 545 (2005). 미소장
30 Poly(epsilon-caprolactone) and poly (L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury. 네이버 미소장
31 Activated Macrophages and the Blood–Brain Barrier: Inflammation after CNS Injury Leads to Increases in Putative Inhibitory Molecules 네이버 미소장

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