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The antimicrobial effect of the methanol extract of Inula britannica flowers against methicillin resistant Staphylococcus aureus
(MRSA) was investigated. It was confirmed that the methanol extract is mainly composed of quercetin, which has antimicrobial
properties. The antimicrobial effect of the methanol extract against 3 MRSA strains was determined by the disc diffusion
method. The minimal inhibitory concentrations were ranged from 0.625 mg/ml to 1.25 mg/ml, and the minimum bactericidal
concentrations were 2.5 mg/ml. Time kill kinetics revealed bactericidal activities, and the morphological alterations in S. aureus
ATCC 33591 treated with the extract were observed using a scanning electron microscope. The methanol extract affected the
expression of the resistant genes, mecA, mecI, and mecRI in mRNA. Therefore, the methanol extract of I. britannica flowers
clearly demonstrated an antimicrobial effect against MRSA and these results suggest a potential for application as a natural
antimicrobial agent.| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Hirai I, Okuno M, Katsuma R, Arita N, Techibana M, Yamamoto Y. 2010. Characterization of anti-Staphylococcus aureus activity of quercetin. Int. J. Food Sci. Tech. 45: 1250-1254. | 미소장 |
| 2 | Högberg LD, Heddini A, Cars O. 2010. The global need for effective antibiotics: challenges and recent advances. Trends Pharmacol. Sci. 31: 509-515. | 미소장 |
| 3 | Biotechnology Journal 10/2010 ![]() |
미소장 |
| 4 | Khan AL, Hussain J, Hamayun M, Gilani SA, Ahmad S, Rehman G, et al. 2010. Secondary metabolites from Inula britannica L. and their biological activities. Mol. 15: 1562-1577. | 미소장 |
| 5 | Antibacterial activity of polygodial ![]() |
미소장 |
| 6 | Suppression of methicillin resistance in a mecA-containing pre-methicillin-resistant Staphylococcus aureus strain is caused by the mecI-mediated repression of PBP 2' production. ![]() |
미소장 |
| 7 | Lee JH, Van ND, Ma JY, Kim YB, Kim SK, Paik HD. 2010. Screening of antiviral medicinal plant against avian influenza virus H1N1 for food safety. Korean J. Food Sci. Anim. Resour. 30: 345-350. | 미소장 |
| 8 | Antimicrobial properties of whole milk with Inula britannica extract against Bacillus cereus strains during storage ![]() |
미소장 |
| 9 | Effect of Saliva miltiorrhiza bunge on antimicrobial activity and resistant gene regulation against methicillin-resistant Staphylococcus aureus (MRSA). | 소장 |
| 10 | Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus. ![]() |
미소장 |
| 11 | The role of femA regulating gene on methicillin-resistant Staphylococcus aureus clinical isolates ![]() |
미소장 |
| 12 | Genetic organization of mecA and mecA-regulatory genes in epidemic methicillin-resistant Staphylococcus aureus from Australia and England ![]() |
미소장 |
| 13 | Antimicrobial effects of aqueous plant extracts on the fungi Microsporum canis and Trichophyton rubrum and on three bacterial species. ![]() |
미소장 |
| 14 | Nyman JA, Lees CH, Bockstedt LA, Filice GA, Lexau C, Lesher LJ, et al. 2011. Cost of screening intensive care unit patients for methicillin-resistant Staphylococcus aureus in hospitals. Am. J. Intect. Control. 39: 27-34. | 미소장 |
| 15 | In vitro activity of Inula helenium against clinical Staphylococcus aureus strains including MRSA. ![]() |
미소장 |
| 16 | Shan B, Cai Y, Brooks JD, Corke H. 2007. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. Int. J. Food Microbiol. 117: 112-119. | 미소장 |
| 17 | Hepatoprotective effects of Inula britannica on hepatic injury in mice. ![]() |
미소장 |
| 18 | Foodborne diseases in Malaysia: A review ![]() |
미소장 |
| 19 | Talib WH, Mahasneh AM. 2010. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine. Mol. 15: 1811-1824. | 미소장 |
| 20 | A new biisoflavonoid from the roots of Erythrina variegata. ![]() |
미소장 |
| 21 | Microbiological safety standards and public health goals to reduce foodborne disease ![]() |
미소장 |
| 22 | Analysis of propolis: some parameters and procedures for chemical quality control ![]() |
미소장 |
| 23 | The antibacterial principle of Caesalpina sappan. ![]() |
미소장 |
| 24 | Yang JH, Lin HC, Mau JL. 2002. Antioxidant properties of several commercial mushrooms. Food Chem. 77: 229-235. | 미소장 |
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