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Acinetobacter infections are of great concern in clinical settings because of multi-drug resistance (MDR) and high mortality of the infected patients. The MDR Acinetobacter baumannii has emerged as a significant infectious agent in hospitals worldwide. The purpose of this study was to determine for molecular characterization of MDR A. baumannii clinical isolates obtained from the Wonju Christian Hospital in Gangwon province of Korea. A total of seventy nonduplicate A. baumannii isolates were collected from the Wonju Christian Hospital in Korea from March to April in 2011. All of the MDR A. baumannii isolates were encoded by blaOXA-23-like gene and all isolates with the blaOXA-23-like gene had the upstream element ISAba1 to promote increased gene expression and subsequent resistance to carbapenem. 16S rRNA methylase gene (armA) was detected in 44 clinical isolates which were resistant to amikacin, and phosphotransferase genes encoding aac(3)-Ia and aac(6')-Ib were the most prevalent. A combination of 16S rRNA methylase and aminoglycosidemodifying enzyme genes (armA, aac(3)-Ia, aac(6')-Ib, and aph(3')-Ia) were found in 31 isolates. The sequencing results for the quinolone resistance-determining region (QRDR) of gyrA and parC revealed the presence of Ser (TCA) 83 Leu (TTA) and Ser (TCG) 80 Leu (TTG) substitutions in the respective enzymes for all MDR. Molecular typing for MDR A. baumannii could be helpful in confirming the identification of a common source or cross-contamination. This is an important step in enabling epidemiological tracing of these strains.

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기사명 저자명 페이지 원문 목차
The Reason of High Prevalence of Vancomycin-Resistant (VR) E. faecium in Nosocomial Infection 주현정, 장경수, 김희정, 이효진, 박규남, 김민주, 안동준 pp.83-85

Effects of Soybean Peptide Intake on Antioxidant Enzyme, Cortisol and Inflammatory Cytokines in High School Judo Athletes 배수정, 황석연, 이다경, 손창섭, 이혜숙, 이장운, 이윤복, 유영춘, 박진홍, 홍승복 pp.22-28

Studies on the Biological Activity of Astragalus membranaceus Extracts 김준호 pp.35-41

A Correlation between Urinary Methylhippuric Acid and Hematologic Finding and Urinalysis Index due to Xylene Exposure 이원건, 현성희, 강상순, 김인식 pp.42-48

Association between Metabolic Syndrome and Physical Fitness in Postmenopausal Women Min-Ju Ku, Kyung-A Shin, Kwang-Jun Ko, Jae-Keun Oh pp.63-70

Identification of Differentially Expressed Genes by TCDD in Human Bronchial Cells : Toxicogenomic Markers for Dioxin Exposure 박정무, 이용우, 진경숙 pp.1-9

Analysis of Single Nucleotide Polymorphism of MMP3 Gene in Korean Genome 김수미, 유민, 김수원 pp.76-78

Prevalence of Multi-drug Resistant Acinetobacter baumannii Producing OXA-23-like from a University Hospital in Gangwon Province, Korea 장인호, 김종배, 이규상, 최일, 우영, 김사현, 박민, 우현준, 최연임 pp.79-82

Construction of Expression Vector for Functional Analysis of Target Protein in Streptomyces sp. 이용직, 김현수, 유재기 pp.29-34

Large Cohort Association of Single Nucleotide Polymorphism of PLA2G4A Gene with White Blood Cell Counts in Korean Population 정석률 pp.71-75

Gene Expression According to Electromyostimulation after Atrophy Conditions and Muscle Atrophy in Skeletal Muscle 박창은 pp.49-55

The Extract of Pseudomonas aeruginosa Induces the Apoptosis of the Human Colorectal Cancer Cell Line, HCT 116 Cells, via Mitochondrial Pathway 양은주, 장정현 pp.16-21

A Repeated-dose Oral Toxicity Study of Orostachys japonicus Extract in Sprague-Dawley Rats 류덕선, 이동석, 이미영, 이형선, 김선희, 이경선, Ji-Hye Kwon pp.10-15

Effects of Long-Term High-Fat Diet Feeding on Gene Expression of Inflammatory Cytokines in Mouse Adipose Tissue 오누리, 양진석, 이용호, 황애랑, 정자인, 박성현 pp.56-62

참고문헌 (10건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Genetic basis of resistance to aminoglycosides in Acinetobacter spp. and spread of armA in Acinetobacter baumannii sequence group 1 in Korean hospitals 네이버 미소장
2 Dijkshoorn L, Van Harsselaar B, Tjernberg I, Bouvet PJ, Vaneechoutte M. Evaluation of amplified ribosomal DNA restriction analysis for identification of Acinetobacter genomic species. Syst Appl Microbiol. 1998. 21: 33-39. 미소장
3 Genetic basis of multidrug-resistant Acinetobacter baumannii clinical isolates from three university hospitals in Chungcheong Province, Korea. 소장
4 Lee K, Chong Y, Shin HB, Kim YA, Yong D, Yum JH. Modified Hodge and EDTA-disk synergy tests to screen metallobeta- lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect. 2007. 7: 88-91. 미소장
5 Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea 네이버 미소장
6 Extensively drug-resistant Acinetobacter baumannii: risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study 네이버 미소장
7 Acinetobacter baumannii: emergence of a successful pathogen. 네이버 미소장
8 The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii 네이버 미소장
9 Identification System of Nonfermentative Gram Negative Bacilli Using Microplate 네이버 미소장
10 Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. 네이버 미소장

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