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Background and Purpose Intracranial atherosclerotic stenosis (ICAS) is considered as a major cause of stroke. The carotid intima-media thickness (CIMT), which accurately reflects the burden of generalized atherosclerosis, is also associated with stroke. The aim of this study was to determine the association between the CIMT and ICAS responses to medical treatment. Methods This study constituted part of the “Trial of cilostazol in symptomatic intracranial arterial stenosis”-2 that evaluated the ICAS response after randomized antiplatelet treatment. Magnetic resonance angiography and CIMT measurement were performed at baseline and after 7 months of treatment. CIMT was measured using semiautomated software, and was presented as maximum (CIMT-max) and average (CIMT-ave) values. The change in CIMT was compared relative to the ICAS response (i.e., progression, no-change, and regression). Ordinal logistic regression and analysis of covariance (ANCOVA) were used to analyze the association between the responses. Results Among the 101 enrolled patients, 85 underwent follow-up CIMT measurement. CIMT increased most in the ICAS progression group (CIMT-max: 0.09±0.23, CIMT-ave: 0.04±0.12), and to a lesser degree in the no-change group (CIMT-max: 0.02±0.16, CIMT-ave: 0.02±0.11), but decreased in patients with ICAS regression (CIMT-max: -0.04±0.11, CIMT-ave: -0.03±0.07; CIMT-max: p=0.010, CIMT-ave: p=0.015). Ordinal logistic regression analysis demonstrated that the change in CIMT-max was independently associated with the ICAS response (p=0.032). However, the ANCOVA revealed that the reverse was not true, in that the ICAS response was not independently associated with the change in CIMT after adjusting for confounding factors.
Conclusions The ICAS response may be associated with the CIMT response to medical treatment.| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 1 | Progression and clinical recurrence of symptomatic middle cerebral artery stenosis: a long-term follow-up transcranial Doppler ultrasound study. ![]() |
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| 2 | Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study. ![]() |
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| 3 | Relationship Between Carotid Intima-Media Thickness and Symptomatic and Asymptomatic Peripheral Arterial Disease ![]() |
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| 4 | Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery the Rotterdam Study ![]() |
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| 5 | Correlation of large artery intracranial occlusive disease with carotid intima-media thickness and presence of carotid plaque. ![]() |
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| 6 | Efficacy and safety of combination antiplatelet therapies in patients with symptomatic intracranial atherosclerotic stenosis. ![]() |
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| 7 | Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis 2012;34:290-296. | 미소장 |
| 8 | Evaluation of a New Carotid Intima-Media Thickness Measurement by B-Mode Ultrasonography Using an Innovative Measurement Software, Intimascope ![]() |
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| 9 | Association of the metabolic syndrome with intracranial atherosclerotic stroke. ![]() |
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| 10 | Endothelial function predicts progression of carotid intima-media thickness. ![]() |
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| 11 | Association between changes in lipid profiles and progression of symptomatic intracranial atherosclerotic stenosis: a prospective multicenter study. ![]() |
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| 12 | Coexisting carotid atherosclerosis in patients with intracranial small- or large-vessel disease. | 소장 |
| 13 | Effect of Statin on Progression of Symptomatic Intracranial Atherosclerosis ![]() |
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| 14 | Effect of Statin Therapy on the Progression of Common Carotid Artery Intima-Media Thickness: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials ![]() |
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| 15 | Effects of cilostazol against the progression of carotid IMT in symptomatic ischemic stroke patients. ![]() |
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| 16 | Extensive or restricted ultrasound protocols to measure carotid intima-media thickness: analysis of completeness rates and impact on observed rates of change over time. ![]() |
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